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Bos, M.F., Ermund A., Hansson, G.C., and de Graaf, J. (2023) Goblet cell interactions reorient bundled mucus strands for efficient airway clearance. PNAS Nexus, 2, pgad388.
Arnesen, H., Markussen, T., Birchenough, G., Birkeland, S., Nystrom, E. E. L., Hansson, G. C., Carlsen, H., and Boysen, P. (2023) Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse colons. Scientific Reports 13, 13701.
REVIEW Luis, A.S. and Hansson, G.C. (2023) Intestinal mucus and their glycans: A habitat for thriving microbiota. Cell Host & Microbe 31, 1087-1100.
Bulck, C., Nystrom, E., Koudelka, T., Mannbar-Frahm, M., Andresen, G., Radhouani, M., Tran, F., Scharfenberg, F., Schrell, F., Armbrust, F., Dahlke, E., Zhao, B., Vervaeke, A., Theilig, F., Rosenstiel, P., Starki, P., Rosshart, S. P., FIckenscher, H., Tholey, A., Hansson, G. C., and Becker-Pauly, C. (2023) Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host microbiome homeostasis. Science Advances 9, eadf4055.
Rodriguez-Pineiro, A.M., Jaudas, F., Klymiuk, N., Bahr, A., Hansson, G.C., and Ermund, A. (2023) Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets. Respiratory Research 24(1), 83.
Gallego, P., Garcia-Bonete, M. J., Trillo-Muyo, S., Recktenwald, C. V., Johansson, M. E. V., and Hansson, G. C. (2023) The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins. Nature Communications, on-line.
Birchenough, G. M. H., Schroeder, B. O., Sharba, S., Arike, L., Recktenwald, C. V., Puertolas-Balint, F., Subramani, M. V., Hansson, K. T., Yilmaz, B., Linden, S. K., Backhed, F., and Hansson, G. C. Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection. Cell Reports 42(2). 2-28-2023
REVIEW Raba, G. and Luis, A. S. Mucin utilization by gut microbiota: recent advances on characterization of key enzymes. Essays in Biochemistry 67, 345-353. 2023
REVIEW Luis, Ana S, Yates, Edwin A, and Cartmell, Alan. Functions and specificity of bacterial carbohydrate sulfatases targeting host glycans. Essays in Biochemistry 67(3), 429-442. 2023
PERSPECTIVE Hansson, G. C. (2022) A Golgi oxygen 3 sensor controls intestinal mucin glycosylation. EMBO J., e2484.
*Hoang, O. N., *Ermund, A., Jaramillo, A. M., Fakih, D., French, C. B., Flores, J. R., Karmouty-Quintana, H., Magnusson, J. M., Fois, G., Fauler, M., Frick, M., Braubach, P., Hales, J. B., Kurten, R. C., Panettieri, R., Vergara, L., Ehre, C., Adachi, R., Tuvim, M. J., *Hansson, G. C., and *Dickey, B. F. Mucins (2022) MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules. Am. J. Resp. Crit. Care Med. 206, 1081-1095. *Equal contribution
REVIEW Ehre, C., Hansson, G. C., Thornton, D. J., Ostedgaard, and Ostedgaard, L. S. (2022) Mucus Aberrant Properties in CF: Insights from Cells and Animal Models. J. Cystic Fibrosis, 22, S23-S26.
Dolan, B., Ermund, A., Martinez-Abad, B., Johansson, M. E.V. and Hansson, G. C. (2022) Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. Science Signaling, 15, eabl5848
Lang, Tiange and Pelaseyed, Thaher. (2022) Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7. PLoS ONE 17, e0275671. 10-18-2022
REVIEW Gustafsson, J. K. and Johansson, M. E. V. (2022( The role of goblet cells and mucus in intestinal homeostasis. Nature Reviews Gastroenterology & Hepatology 19, 785-803.
REVIEW Suriano, F., Nystrom, E. E. L., Sergi, D., and Gustafsson, J. K. (2022) Diet, microbiota, and the mucus layer: The guardians of our health. Frontiers Immmunol. DOI 10.3389/fimmu.2022.953196.
PERSPECTIVE Hansson, G. C. (2022) A Golgi oxygen 3 sensor controls intestinal mucin glycosylation. EMBO J., e2484.
REVIEW Ehre, C., Hansson, G. C., Thornton, D. J., Ostedgaard, and Ostedgaard, L. S. (2022) Mucus Aberrant Properties in CF: Insights from Cells and Animal Models. J. Cystic Fibrosis, on-line.
PERSPECTIVE Johansson, M. E. V. and Hansson, G. C. (2022) Goblet cells need some stress. J. Clin. Invest. 132 (17), e162030.
Hoang, Oanh N., Ermund, Anna, Jaramillo, Ana M., Fakih, Dalia, French, Cory B., Flores, Jose R., Karmouty-Quintana, Harry, Magnusson, Jesper M., Fois, Giorgio, Fauler, Michael, Frick, Manfred, Braubach, Peter, Hales, Joshua B., Kurten, Richard C., Panettieri, Reynold, Vergara, Leoncio, Ehre, Camille, Adachi, Roberto, Tuvim, Michael J., Hansson, Gunnar C., and Dickey, Burton F. (2022) Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules. Am.J.Resp.Crit.Care Med. 206, 1081-1095.
Luis, Ana S., Basle, Arnaud, Byrne, Dominic P., Wright, Gareth S. A., London, James A., Jin, Chunsheng, Karlsson, Niclas G., Hansson, Gunnar C., Eyers, Patrick A., Czjzek, Mirjam, Barbeyron, Tristan, Yates, Edwin A., Martens, Eric C., and Cartmell, Alan. (2022) Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. Nature Chemical Biology 18, 841-849.
Sharpen, J. D. A., Dolan, B., Nystrom, E. E. L., Birchenough, G. M. H., Arike, L., Martinez-Abad, B., Johansson, M. E. V., Hansson, G. C. and Recktenwald, C. V. (2022) Transglutaminase 3 crosslinks the secreted MUC2 mucin and stabilizes the colonic mucus layer. Nature Communications, 13, 45.
Dolan, B. and Hansson, G. C. (2022) Mucins. Encyclopedia in Cell Biology 2d, Encyclopedia in Cell Biology. In press.
Ermund, A., Meiss, L. N., Dolan, B., Jaudas, F., Ewaldsson, L., Bahr, A., Klymiuk, N., and Hansson, G. C. (2021) Mucus threads from surface goblet cells clear particles from the airways. Respiratory Research 22(1), 303.
Sheikh, A., Wangdi, T., Vickers, T. J., Aaron, B., Palmer, M., Miller, M. J., Kim, S., Herring, C., Simoes, R., Crainic, J. A., Gildersleeve, J. C., van der Post, S., Hansson, G. C., and Fleckenstein, J. M. (2021) Enterotoxigenic Escherichia coli degrades the host MUC2 mucin barrier to facilitate critical pathogen-enterocyte interactions in human small intestine. Infection and Immunity, on line.
Luis, A. S., Jin, C., Pereira, G., Glowaki, R., Gugel, S., Sing, S., Byrne, D. P., Pudlo, N., London, J., Basle, A., Reihill, M., Oscarsson, S., Karlsson, N. G., Eyres, P., Czjzek, M., Michel, G., Barbeyron, T., Yates, E. A., Hansson, G. C., and Martens, E. C. (2021) A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium. Nature 598, 332-337.
Gustafsson, Jenny K., Davis, Jazmyne E., Rappai, Tracy, McDonald, Keely G., Kulkarni, Devesha H., Knoop, Kathryn A., Hogan, Simon P., Fitzpatrick, James AJ, Lencer, Wayne I., and Newberry, Rodney D. (2021) Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis. eLife 10, e67292.
Nonnecke, Eric B., Castillo, Patricia A., Dugan, Amanda E., Almalki, Faisal, Underwood, Mark A., De La Motte, Carol A., Yuan, Weirong, Lu, Wuyuan, Shen, Bo, Johansson, Malin E. V., Kiessling, Laura L., Hollox, Edward J., Lonnerdal, Bo, and Bevins, Charles L. (2021) Human intelectin-1 (ITLN1) genetic variation and intestinal expression. Scientific Reports 11(1), 12889.
Ehrencrona, E., van der Post, S., Gallego, P., Recktenwald, C. V., Rodriguez-Pineiro, A. M., Garcia-Bonete, M. J., Trillo-Muyo, S., Backstrom, M., Hansson, G. C., and Johansson, M. E. V. (2021) The IgG Fc-binding protein FCGBP is secreted with all GDPH sequences cleaved, but maintained by inter-fragment disulfide bonds. J. Biol. Chem. 297, 100871.
Giorgetti, M., Klymiuk, N., Bahr, A., Hemmerling, M., Jinton, L., Tarran, R., Malmgren, A., Astrand, A., Hansson, G. C., and Ermund, A. (2021) New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger inhibition. European Journal of Pharmacology 904, 174123.
van der Post, S. and Arike, L. (2021) Metaproteomics Analysis of Host-Microbiota Interfaces. Methods Mol Biol 2259, 167-179.
Nystrom, E. E. L., Martinez-Abad, B., Arike, L., Birchenough, G. M. H., Nonnecke, E. B., Castillo, P. A., Svensson, F., Bevins, C. L., Hansson, G. C., and Johansson, M. E. V. (2021) An intercrypt subpopulation of goblet cells are essential for colonic mucus barrier function. Science 372, 257.
Layunta, Elena, Javerfelt, Sofia, Dolan, Brendan, Arike, Liisa, and Pelaseyed, Thaher. (2021) IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning. Cell Reports 34(7), 108757.
van der Post, Sjoerd, Birchenough, George M. H., and Held, Jason M. (2021) NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation. Cell Reports 35(1), 108949.
Schroeder, B. O., Birchenough, G. M. H., Pradhan, M., Nystrom, E. E. L., Henricsson, M., Hansson, G. C., and Backhed, F. (2020) Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice. J. Biol. Chem. 296, 15712-15726.
REV: Hansson, G. C. (2020) Mucins and the Microbiome. Annual Rev. Biochem. 89, 769-793.
Arike, L., Hansson, G. C., and Recktenwald, C. V. (2020) Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps. Anal. Biochem. 597, 113668.
Fakih, D., Rodriguez Pineiro, A. M., Trillo-Muyo, S., Evans, C. M., Ermund, A., and Hansson, G. C. (2020) Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin. Am. J. Physiol. Lung Cell Mol. Physiol, 318, L1270-L1279.
Jabbar, K. S., Dolan, B., Eklund, L., Wising, C., Ermund, A., Johansson, A., Tornblom, H., Simren, M., and Hansson, G. C. (2020) Association between Brachyspira and irritable bowel syndrome with diarrhoea. Gut, on-line.
281. REV: Pelaseyed, Thaher and Hansson, Gunnar C. (2020) Membrane mucins of the intestine at a glance. Journal of Cell Science 133(5), jcs240929.
280. Arike, Liisa, Seiman, Andrus, van der Post, Sjoerd, Rodriguez Pineiro, Ana M., Ermund, Anna, Schutte, Andre, Backhed, Fredrik, Johansson, Malin E. V., and Hansson, Gunnar C. Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota. Cell Reports 30(4), 1077-1087.
279. Nystrom, E. E. L., Arike, L., Ehrencrona, E., Hansson, G. C., and Johansson, M. E. V. CLCA1 forms non-covalent oligomers in colonic mucus and has MUC2-processing properties. J. Biol. Chem., 294, 17075-17089, 2019
278. Volk, J.K., Abad, B.M., Nystrom, E. E. L., Svensson, F., Javerfelt, S., Hansson, G.C., Johansson, M. E. V., Birchenough, G. M. H. (2019) Inflammasome activity is not required for inner mucus layer formation or function in the distal colon. J. Exp. Med., 216, 2602-2618.
277. Schneider, H., Berger, E., Dolan, B., Martinez-Abad, B., Arike, L., Pelaseyed, T., and Hansson, G. C. (2019) The human transmembrane mucin MUC17 responds to TNF? by increased presentation at the plasma membrane. Biochem. J., 476, 2281-2295.
276. Blacher, Eran, Bashiardes, Stavros, Shapiro, Hagit, Rothschild, Daphna, Mor, Uria, Dori-Bachash, Mally, Kleimeyer, Christian, Moresi, Claudia, Harnik, Yotam, Zur, Maya, Zabari, Michal, Brik, Rotem Ben-Zeev, Kviatcovsky, Denise, Zmora, Niv, Cohen, Yotam, Bar, Noam, Levi, Izhak, Amar, Nira, Mehlman, Tevie, Brandis, Alexander, Biton, Inbal, Kuperman, Yael, Tsoory, Michael, Alfahel, Leenor, Harmelin, Alon, Schwartz, Michal, Israelson, Adrian, Arike, Liisa, Johansson, Malin E. V., Hansson, Gunnar C., Gotkine, Marc, Segal, Eran, and Elinav, Eran. (2019) Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature 572, 474-480.
275. Vega, G., Guequen, A., Johansson, M. E. V., Arike, L., Martinez-Abad, B., Nystrom, E. E. L., Scudieri, P., Pedemonte, N., Millar-Buchner, P., Philp, A. R., Galietta, L. J., Hansson, G. C., and Flores, C. A. (2019) Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium. Frontiers in Physiology 10, 694.
274. Furter, M., Sellin, M. E., Hansson, G. C., and Hardt, W. D. (2019) Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract. Cell Reports 27(9), 2665-2678.
273. REV: Hansson, G. C. (2019) Mucus and mucins in diseases of the intestinal and respiratory tracts. J. Internal Medicine 285, 479-490.
272. van der Post, S, Jabbar, K. S., Birchenough, G., Arike, L., Akhtar, N., Sjovall, H., Johansson, M. E. V., and Hansson, G.C. (2019) Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis. Gut, DOI: 10.1136/gutjnl-2018-317571
271. P: Birchenough, G., Schroeder, B. O., Backhed, F., and Hansson, G. C. (2019) Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier. Gut Microbes 10, 246-250.
270. Svensson, F., Lang, T., Johansson, M. E. V., and Hansson, G. C. (2018) The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals. Scientific Reports 8, 17503.
269. R Ermund, A., Trillo-Muyo, S., and Hansson, G. C. (2018) Assembly, Release, and Transport of Airway Mucins in Pigs and Humans. Ann. Am. Thorac. Soc. 15, S159-S163.
268. Fernandez-Blanco, J. A., Fakih, D., Arike, L., Rodriguez-Pineiro, A., Martinez-Abad, B., Skansebo, E., Jackson, S., Root, J., Singh, D., McCrae, C., Evans, C. M., Astrand, A., Ermund, A., and Hansson, G. C. (2018) Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs. J. Clin. Invest.Insights 3, e120994.
267. Ermund, A., Meiss, L. N., Dolan, B., Bahr, A., Klymiuk, N., and Hansson, G. C. (2018) The mucin bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation. Eur. Resp. J. 52(2), 1800457.
266. Nystrom, E. E. L., Birchenough, G. M. H., van der Post, S., Arike, L., Gruber, A. D., Hansson, G. C., and Johansson, M. E. V. (2018) Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity. EBioMed 33, 134-143.
265. Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bahr A, Klymiuk N, Wine JJ, Koeck PJ, Thornton DJ, Hebert H, Hansson GC (2018) Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers.. J. Biol. Chem. 293, 5746-5754.
264. Jabbar, Karolina S., Arike, Liisa, Verbeke, Caroline S., Sadik, Riadh, and Hansson, Gunnar C. (2018) Highly Accurate Identification of Cystic Precursor Lesions of Pancreatic Cancer Through Targeted Mass Spectrometry: A Phase IIc Diagnostic Study. J.Clin.Oncology 36 367-375. IMPACT 24
263. Wichert, Rielana, Ermund, Anna, Schmidt, Stefanie, Schweinlin, Matthias, Ksiazek, Miroslaw, Arnold, Philipp, Knittler, Katharina, Wilkens, Frederike, Potempa, Barbara, Rabe, Bjorn, Stirnberg, Marit, Lucius, Ralph, Bartsch, Jorg W., Nikolaus, Susanna, Falk-Paulsen, Maren, Rosenstiel, Philip, Metzger, Marco, Rose-John, Stefan, Potempa, Jan, Hansson, Gunnar C., Dempsey, Peter J., and Becker-Pauly, Christoph. (2017) Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Reports 21, 2090-2103.
262. Schroeder, B. O., Birchenough, G. M.H., Ståhlman, M., Arike, L., Johansson, M. E.V., Hansson, G. C. and Bäckhed, F. (2017) Bifidobacterium and fiber protect against diet-induced deterioration of the inner colonic mucus layer. CELL Host & Microbe, 23, 27-40
261. Wine, J. J., Hansson, G. C., Konig, P., Joo, N. S., Ermund, A., and Pieper, M. (2017) Progress in understanding mucus abnormalities in cystic fibrosis airways. J.Cystic Fibrosis 17, S35-S39.
260. Ermund, A., Meiss, L. N., Rodriguez-Pineiro, A. M., Bähr, A., Nilsson, H. E., Trillo-Muyo, S., Ridley, C., Thornton, D. J., Wine, J. J., Hebert, H., Klymiuk, N., and Hansson, G. C. (2017) The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin. Biochem. Biophys. Res. Commun. 492, 331-337.
259. Birchenough, G.M.H. and Hansson, G.C. (2017) Bacteria Tell Us How to Protect Our Intestine. CELL Host & Microbe 22, 3-4.
258. Ermund, A., Recktenwald, C. V., Skjak-Braek, G., Meiss, L. N., Onsoyen, E., Rye, P. D., Dessen, A., Myrset, A. H., and Hansson, G. C. (2017) OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating calcium. Clin. Exp. Pharmacol. Physiol., 44, 639-647.
257. Birchenough, G.M.H., Dalgakiran, F., Witcomb, L. A., Johansson, M. E. V., McCarthy, A. J., Hansson, G. C. and. Taylor, P. W. (2017) Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection. Sci. Rep. 7, 83
256. Bosmans, J. W. A. M., Jongen, A. C. H. M., Birchenough, G. M. H., Nystr+Âm, E. E. L., Gijbels, M. J. J., Derikx, J. P. M., Bouvy, N. D., and Hansson, G. C. (2017) Functional mucous layer and healing of proximal colonic anastomoses in an experimental model. Brit. J. Surgery , 104, 619-630.
255. Arike, L., Holmén-Larsson, J., and Hansson G.C. (2017) Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases. Glycobiology, 27, 318-328
254. Bergström, J. H., Birchenough, G. M. H., Katona, G., Schroeder, B. O., Schutte, A., Ermund, A., Johansson, M. E. V., and Hansson G. C. (2016) Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc. Natl. Acad. Sci. USA 113, 13833-13838.
253. Birchenough, G. M. H., Nystrom, E. L. N., Johansson, M. E. V., and Hansson G. C. (2016) A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science 352, 1535-1542.
252R. Johansson, M. E. V. and Hansson, G. C. (2016) Immunological aspects of intestinal mucus and mucins. Nature Rev.Immunol. 16, 639-649.
251. Lang, T., Klasson, S., Larsson, E., Johansson, M. E. V., Hansson, G. C., and Samuelsson T. (2016) Searching the Evolutionary Origin of Epithelial Mucus Protein Components; Mucins and FCGBP. Mol. Biol. Evolution, 33, 1921-1936
250R. Johansson, M. E. V. and Hansson, G. C. (2016) The Mucins. Encyclopedia Immunobiology 2, 381-388.
249. Recktenwald, C. V. and Hansson, G. C. (2016) The reduction-insensitive bonds of the MUC2 mucin are isopeptide bonds. J.Biol.Chem. 249, 13580-13590.
248. Bergstrom, K., Fu, J., Johansson, M. E., Liu, X., Gao, N., Wu, Q., Song, J., McDaniel, J. M., McGee, S., Chen, W., Braun, J., Hansson, G. C., and Xia. (2016) L. Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice. Mucosal Immunol. 10, 91-103.
247R. Arike, L. and Hansson, G.C. (2016) The Densely O-glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal Bacteria. J. Mol. Biol. 428, 3221-3229.
246. Earle, K. A., Billings, G., Sigal, M., Lichtman, J. S., Hansson, G. C., Elias, J. E., Amieva, M. R., Huang, K. C., and Sonnenburg, J. L. (2015) Quantitative Imaging of Gut Microbiota Spatial Organization. Cell Host Microbe 18, 478–488, 478–488.
245. Johansson, M. E. V., Jacobsson, H. E., Holmén-Larsson, J., Schütte, A., Ermund, A., Rodriguez-Pineiro, A., Arike, L., Wising, C., Svensson, F., Bäckhed, F., and Hansson G. C. (2015) Normalization of the host intestinal mucus systems requires long-term colonization. Cell Host Microbe 18: 582-592.
244. Ermund, A., Meiss, L. N. Gustafsson, J. K., and Hansson, G. C. (2015) Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus. Eur J Pharmacol. 764: 109-117.
243. Wenzel, U. A., Jonstrand, C., Hansson, G. C., and Wick, M. J. (2015) CD103+CD11b+ dendritic cells induce TH17 T cells in Muc2-deficient mice with extensively spread colitis. PLoS ONE 10: e0130750.
242. Hickey, C. A., Kuhn, K. A., Donermeyer, D. L., Porter, N. T., Jin, C., Cameron, E. A., Jung, H., Kaiko, G. E., Wegorzewska, M., Malvin, N. P., Glowacki, R. W., Hansson, G. C., Allen, P. M., Martens, E. C., and Stappenbeck T. S. (2015) Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles. Cell Host Microbe. 17, 672-680.
241. Birchenough, G. M. H., Johansson, M. E. V., Gustafsson, J.K., Bergstrom, J.H., and Hansson, G. C. (2015) New developments in goblet cell mucus secretion and function. Mucosal Immunol. on-line
240. Hannan, T.J., Roberts, P.J., Riehl, T.E., van der Post, S., Binkley, J. M., Schwartz, D.J., Miyoshi, H., Mack, M., Schwendener, R.A., Hooton, T.M., Stappenbeck, T.S., Hansson, G.C., Stenson, W.F., Colonna, M., Stapleton, A.E. and Hultgren, S.J. (2014) Inhibition of cyclooxygenase-2 prevents chronic and recurrent bladder infection. EBioMedicine, 2014.10.011
239. van der Post, S., Thomsson, K.A., and Hansson, G. C. (2014) A multiple enzyme approach for the characterization of glycan modifications on the C-Terminus of the intestinal MUC2 mucin. J. Proteome Res., 13, 6013-6023.
238. Ermund, A., Meiss, L., Scholte, B. J., and Hansson G. C. (2015) Hypertonic saline releases the attached small intestinal cystic fibrosis mucus. Clin. Exp. Pharm. Physiol. 42, 69-75.
237. Gustafsson, J. K., Linden, S. K., Alwan, A. H., Scholte, B. J., Hansson, G. C., and Sjovall, H. (2015) Carbachol-induced colonic mucus formation requires transport via NKCC1, K channels and CFTR. Pflugers Arch., DOI 10.1007/s00424-014-1595-y.
236. Sadio, A. Gustafsson, J. K, Pereira, B., Gomes, C.P., Hansson, G. C., David, L., Pego, A. P., and Almeida, R. (2014) Modified-Chitosan/siRNA Nanoparticles Downregulate Cellular CDX2 Expression and Cross the Gastric Mucus Barrier. PLoS ONE 9 (6):e99449.
513. Johansson, M. E. V. (2014) Mucus Layers in Inflammatory Bowel Disease. Inflamm. Bowel. Dis., on-line.
235. Berström, J. H., Berg, K. A., Rodriguez-Pineiro, A. M., Stecher, B., Johansson, M. E. V., and Hansson, G. C. (2014) AGR2, nn endoplasmic reticulum protein is secreted into the gastrointestinal mucus. PLoS ONE 9 (8):e104186.
234. van der Post, S. and Hansson, G.C. (2014). Membrane protein profiling of human colon reveals distinct regional differences. Mol. Cell. Proteomics 13, 2277-2287.
233. Jakobsson, H. E., Rodriguez-Pineiro, A. M., Schütte, A., Ermund, A., Boysen, P., Sommer, F., Bäckhed, F., Hansson, G. C., and Johansson M. E. V. (2014) The gut microbiota composition impairs the colon inner mucus layer barrier. EMBO Reports in press.
232. Schütte, A., Ermund, A., Becker-Pauly, C., Johansson, M.E.V., Rodriguez-Pineiro, A. M., Bäckhed, Müller, F.S., Lottaz, D., Bond, J.S., and Hansson, G.C. (2014) Microbial Induced Meprin ß Cleavage in MUC2 Mucin and Functional CFTR Channel are Required to Release Anchored Small Intestinal Mucus. Proc.Natl.Acad.Sci.USA 111, 12396-12401.
231. Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A. van der Post, S, Svensson, F., Rodríguez-Piñeiro, A. M., Nyström, E. E.L., Wising, C., Johansson, M. E.V., and Hansson, G. C. (2014) The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol. Rev., 260, 8-20.
230. Wenzel, U.A., Magnusson, M. K., Rydström, A., Jonstrand, C., Hengst, J., Johansson, M.E.V., Velcich, A., Öhman, L., Strid, H., Sjövall, H., Hansson, G.C., and Wick, M.J. (2014) Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis. PLoS ONE, 9, e100217.
229. Nilsson, H. E., Ambort, D., Backstrom, M., Thomsson, E., Koeck, P. J., Hansson, G. C., and Hebert, H. (2014) Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly. J.Mol.Biol. 426, 2567-2579
228. Jabbar, K. S., Verbeke, C., Hyltander, A. G., Sjovall, H., Hansson, G. C., and Sadik, R. (2014) Proteomic Mucin Profiling for the Identification of Cystic Precursors of Pancreatic Cancer. J.Natl.Cancer Inst. 106, djt439. IMPACT 14.3
227P. Johansson, M.E.V. and Hansson, G.C. (2014) Is the intestinal goblet cell a major immune cell? CELL Host & Microbe, 15, 251-252.
226. Xiao, F., Yu, Q., Li, J., Johansson, M. E., Singh, A. K., Xia, W., Riederer, B., Engelhardt, R., Montrose, M., Soleimani, M., Tian, D. A., Xu, G., Hansson, G. C., and Seidler, U. (2014) Slc26a3 deficiency is associated with loss of colonic HCO secretion, absence of a firm mucus layer, and barrier impairment in mice. Acta Physiol (Oxf), 211, 161-175.
225. Sommer, F., Adam, N., Johansson, M. E. V., Xia, L., Hansson, G. C., and Bäckhed, F. (2014) Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture. PLoS ONE 9, e85254
224. Gustafsson, J. K., Navabi, N., Rodriguez-Pineiro, A. M., Alomran, A. H. A., Premaratne, P., Fernandez, H. R., Banerjee, D., Sjövall, H., Hansson, G. C., and Lindén, S. K. (2013) Dynamic changes in mucus thickness and ion secretion during Citrobacter rodentium infection and clearance. PLoS ONE 8, e84430
223. Ermund, A., Gustafsson, J. K., Hansson, G. C., and Keita, Å. A. (2013) Mucus properties and goblet cell guantification in mouse, rat, and human ileal Peyer's patches PLoS ONE, 8, e83688
222. Johansson, M. E. V. and Hansson, G. C. (2013) Mucus and the Goblet Cell. Digestive Dis., 31, 305-309.
221. Birchenough, G. M. H., Johansson, M. E. V., Stabler, R. A., Dalgakiran, F., Hansson, G. C., Wren, B. W., Luzio, J. P., and Taylor, P. W. (2013) Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia coli. Infect. Immun. 81, 3264-3275.
220. Pelaseyed, T., Gustafsson, J. K., Gustafsson, I. J., Ermund, A., and Hansson, G. C. (2013) Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes. Am. J. Physiol. Cell Physiol. 305, C457-C467.
219. Holmen-Larsson, J. M., Thomsson, K. A., Rodriguez-Pineiro, A. M., Karlsson, H., and Hansson, G. C. (2013) Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution. Am. J. Physiol. Gastroint. Liver. Physiol.G357-G363.
218. Rodriguez-Pineiro, A. M., Bergstrom, J. H., Ermund, A., Gustafsson, J. K., Schutte, A., Johansson, M. E. V., and Hansson, G. C. (2013) Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins Am. J. Physiol. Gastroint. Liver Physiol. 305, G348-G356.
217, Ermund, A., Schutte, A., Johansson, M. E. V., Gustafsson, J. K., and Hansson, G. C. (2013) Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer’s patches. Am. J. Physiol. Gastroint. Liver Physiol. 305, G341-G347.
216. Liu, C., Xu, H., Zhang, B., Johansson, M. E., Li, J., Hansson, G. C., and Ghishan, F. K. (2013) NHE8 plays an important role in mucosal protection Via its effect on bacterial adhesion. Am. J. Phyiol. Cell Physiol. 305, C121-C128.
215. van der Post, S., Subramani, D.B., Malin Bäckström, M., Johansson, M.E.V., Vester-Christensen, M.B., Mandel, U., Bennett, E.P., Clausen, H., Dahlén, G., Sroka, A., Potempa, J., and Hansson, G.C. (2013) Site-specific O-glycosylation on the MUC2 mucin inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB). J. Biol. Chem. 288, 14636-14646.v
214R. Johansson, M. E. V., Sjovall, H., and Hansson, G. C. (2013) The gastrointestinal mucus system in health and disease. Nature Rev.Gastroenterol.Hepatol. 10, 352-361.
213. Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., and Hansson, G. C. (2014) Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and in patients with ulcerative colitis. Gut 63, 281-291. IMPACT 10.7
212R. Backstrom, M., Ambort, D., Thomsson, E., Johansson, M. E. V., and Hansson, G. C. (2012) Increased Understanding of the Biochemistry and Biosynthesis of MUC2 and Other Gel-Forming Mucins Through the Recombinant Expression of Their Protein Domains. Mol Biotechnol. DOI 10.1007/s12033-012-9562-3.
211. Pelaseyed, T., Zäch, M., Petersson, A. C., Svensson, F., Johansson, D. G., and Hansson, G. C. (2013) Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell protective device. FEBS J. 280, 1491-1501.
210. Arampatzidou, M., Schütte, A., Hansson, G.C., Saftig, P., Brix, K. (2012) Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon. Biol Chem. 393, 1391-1403
209. B Ambort, D., Johansson, M.E.V., Gustafsson, J.K., Ermund, A., and Hansson G.C. (2012) Perspectives on Mucus Properties and Formation - Lessons from the Biochemical World. Cold Spring Harbor Perspectives in Medicine. 2(11), a014159
208. L Ambort, D. and Hansson, G.C. (2012) Reply to Verdugo: Mucins form highly organized supramolecular structures. Proc.Natl.Acad.Sci.U.S.A. 109, E2956-2957
512. Frederic A. Carvalho, Omry Koren, Julia K. Goodrich, Malin E.V. Johansson, Ilke Nalbantoglu, Jesse D. Aitken, Yueju Su, Benoit Chassaing, William A. Walters, Antonio Gonzalez, Jose C. Clemente, Tyler C. Cullender, Nicolas Barnich, Arlette Darfeuille-Michaud, Matam Vijay-Kumar, Rob Knight, Ruth E. Ley, and Andrew T. Gewirtz1 (2012) Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice. Cell Host & Microb. 12, 139–152.
511. Johansson, M.E.V. (2012) Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins. PlosONE 7: e41009.
207. Breimer ME, Hansson GC, Karlsson KA, Larson G, and Leffler H. (2012) Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human individual. Glycobiology, 22, 1721-1730
206. Thomsson, K.A., Holmén-Larsson, J., Ångström, J., Johansson, M.E.V., Xia, L., and Hansson, G.C. (2012) Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2. Glycobiology 22, 1128-1139
205P. Johansson, M.E.V. and Hansson, G.C. (2013) The goblet cell: a key player in ischemia-reperfusion injury. Gut 62, 188-189
204. Gustafsson, J.K., Hansson, G. C., and Sjövall, H. (2012) Ulcerative colitis patients in remission have an altered secretory capacity in the proximal colon despite macroscopically normal mucosa. Neurogastroenterol Motil, 24, e381-e391
203. Gustafsson, J.K., Ermund, A., Ambort, D., Johansson, M.E.V., Nilsson, H.E., Thorell, K., Hebert, H., Sjövall, H., and Hansson, G. C. (2012) Bicarbonate and functional CFTR channel are required for proper mucin secretion and link Cystic Fibrosis with its mucus phenotype. J. Exp. Med., 209, 1263-1272
202. Ambort, D., Johansson, M. E. V., Gustafsson, J. K., Nilsson, H., Ermund, A., Johansson, B. R., Kock, P., Hebert, H., and Hansson, G. C. (2012) Calcium and pH-dependent Packing and Release of the Gel-forming MUC2 Mucin. Proc.Natl.Acad.Sci.U.S.A. 109, 5645-5650
201. Rodriguez-Pineiro, A.M., van der Post, S., Johansson, M.E.V., Thomsson, K.A., Nesvizhskii, A.I., and Hansson, G.C. (2012) Proteomic study of the mucin granulae in an intestinal goblet cell model. J. Proteome Res. 11, 1879-1890
200. Johansson, M.E.V., Hansson, G.C. (2012) Preservation of Mucus in Histological Sections, Immunostaining of Mucins in Fixed Tissue, and Localization of Bacteria with FISH. Methods Mol. Biol. 842, 229-235
199. Gustafsson, J.K., Sjövall, H., Hansson, G.C. (2012) Ex vivo measurements of mucus secretion by colon explants. Methods Mol. Biol. 842, 237-243
198. Johansson, M.E.V., Hansson, G.C. (2012) Analysis of assembly of secreted mucins. Methods Mol. Biol. 842, 109-121
197R. Hansson, G.C. (2012) Role of mucus layers in gut infection and inflammation. Curr. Opinion Microbiol. 15, 57-62.
196. Gustafsson, J. K., Ermund, A., Johansson, M. E. V., Schutte, A., Hansson, G. C., and Sjovall, H. (2012) An ex vivo method for studying mucus formation, properties and thickness in human colonic biopsies and mouse small and large intestinal explants. Am. J. Physiol. Gastrointest. Liver Physiol. 302. G430-G438.
195R. Johansson, M. E. V. and Hansson, G. C. (2011) Keeping Bacteria at a Distance. Science 334, 182-183.
193. Songhet, P., Barthel, M., Stecher, B., Müller, A.J., Kremer, M., Hansson, G.C., Hardt W.D. (2011) Stromal IFN-?R-Signaling Modulates Goblet Cell Function During Salmonella Typhimurium Infection. PLoS One. 2011;6(7):e22459.
192. Thomsson, K.A., Hansson, G.C. (2011) Identification and quantification of mucin expression. Methods Mol. Biol. 742, 127-141.
191. Pelaseyed, T. and Hansson, G. C. (2011) CFTR anion channel modulates expression of human transmembrane mucin MUC3 via the PDZ protein GOPC. J. Cell Sci. 124, 3074-3083 IMPACT 5.9
190. Thomsson, E., Persson, L., Grahn, A., Snäll, J., Ekblad, M., Brunhage, E., Svensson, F., Hansson, G.C., Bäckström, M. and Bergström, T. (2011) Recombinant glycoprotein E produced in mammalian cells in large-scale as an antigen for varicella-zoster-virus-serology. J. Virol. Meth., 175, 53-59.
189. Ambort, D., van der Post, S., Mackenzie, J., Johansson, M.E.V., Thomsson, E., Krengel, U., and Hansson, G.C. (2011) Function of the CysD domain of the gel-forming MUC2 mucin. Biochem. J. 436, 61-70.
188B. Bäckström, M., Karlsson, H., Gätgens, J., Noll, T., and Hansson, G. C. (2010) O-glycans on recombinant MUC1 produced in CHO K1 cells become less sialylated with increased protein productivity, as determined by LC-ESI MS in Cells and Culture (Noll, T., ed.) pp. 285-288, Springer
187. Fu, J., Wei, B., Wen, T., Johansson, M.E.V., Xiaowei Liu, X., Bradford, E., Thomsson, K.A., McGee, S., Mansour, L., Tong, M., McDaniel, M., Sferra, T. J., Turner, J. , Chen, H. , Hansson, G. C., Braun, J. ,Xia, L. (2011) Loss of intestinal core 1–derived O-glycans causes spontaneous colitis. J. Clin. Invest., 121, 1657-1666.
186. Subramani, D. B., Johansson, M. E.V., Dahlén, G., and Hansson, G. C. (2010) Probiotic Lactobacillus and Bifidobacterium species do not secrete proteases that can cleave the MUC2 mucin protein core which organizes the colon mucus layers. Beneficial Microbes 1, 343-350.
185. Petersson, J., Schreiber, O.,. Hansson, G.C, Gendler, S.J., Velcich, A., Lundberg, J., Roos, S., Holm, L., and Phillipson, M. (2010) Importance and Regulation of the Colonic Mucus Barrier in a Mouse Model of Colitis. Am. J. Physiology, 300, G327-G333
184. Premaratne, P. Welén, K., Damber, J.-E., Hansson, G.C. and Bäckström M. (2011) O-glycosylation of MUC1 mucin in prostate cancer and the effects of its expression on tumor growth in a prostate cancer xenograft model. Tumor Biol. 32, 203-213.
183. Johansson, M.E.V. Gustafsson, J.K., Sjöberg, K. E., Petersson, J., Holm, L., Sjövall, H. and Hansson, G.C. (2010) Bacteria penetrate the inner mucus layer before inflammation in the Dextran sulfate colitis model. PLOS One, 5, e12238
182P. Hansson, G.C. (2010) Sparkling Water - Bicarbonate for Cervix and Cystic Fibrosis. Perspective for J. Physiol. 588, 2685
181R. Johansson, M.E.V., Holmén Larsson, J. M., and Hansson G. C. (2011) The two mucus layers of colon are organized by the MUC2 mucin – the outer layer is a legislator of host-microbial interactions. Proc. Natl. Acad. Sci. USA 108, 4659-4665.
180. Holmén Larsson, J. M. Karlsson, H., Gråberg Crespo, J., Johansson, M. E. V., Eklund, L., Sjövall, H., and Hansson, G. C. (2011) An Altered O-glycosylation Profile of the MUC2 Mucin Occurs in Active Ulcerative Colitis and is Associated with Increased Inflammation. Infl. Bowel Dis., 17, 2299-2307
179. Thomsson, K. A., Bäckström, M., Holmen-Larsson, J., Hansson, G. C., and Karlsson, H. (2010) Enhanced detection of sialylated and sulfated glycans with negative ion mode nanoliquid chromatography/mass spectrometry at high pH. Anal. Chem. 82, 1470–1477
178. Wada, Yoshinao, Dell, Anne, Haslam, Stuart M., Tissot, Berangere, Canis, Kevin, Azadi, Parastoo, Backstrom, Malin, Costello, Catherine E., Hansson, Gunnar C., Hiki, Yoshiyuki, Ishihara, Mayumi, Ito, Hiromi, Kakehi, Kazuaki, Karlsson, Niclas, Kato, Koichi, Kawasaki, Nana, Khoo, Kay Hooi, Kobayashi, Kunihiko, Kolarich, Daniel, Kondo, Akihiro, Lebrilla, Carlito, Nakano, Miyako, Narimatsu, Hisashi, Novak, Jan, Novotny, Milos V., Ohno, Erina, Packer, Nicolle H., Renfrow, Matthew B., Tajiri, Michiko, Thomsson, K. A., Yagil, H., Yu, S.-Y., and Taniguchi, Naoyuki. (2009) Comparison of Methods for Profiling O-glycosylation: HUPO Human Disease Glycomics/Proteome Initiative Multi-Institutional Study of IgA1. Molecular Cellular Proteomics, . 9, 719-727
177R. Hansson, G. C. and Johansson, M. E. V. (2010) The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Gut Microbes 1, 10-14.
176. Persson, J., Backstrom, M., Johansson, H., Jirstrom, K., Hansson, G. C., and Ohlin, M. (2009) Molecular Evolution of Specific Human Antibody against MUC1 Mucin Results in Improved Recognition of the Antigen on Tumor Cells. Tumor Biol. 30, 221-231.
175. Domino, S. E., Hurd, E. A., Thomsson, K. A., Karnak, D. M., Holmén-Larsson J. M., Thomsson, E., Bäckström, M., and Hansson, G.C. (2009) Cervical Mucins Carry a(1,2)Fucosylated Glycans that Partly Protect from Experimental Vaginal Candidiasis. Glycoconj. J. 26, 1125-1134.
174. Johansson, M.E.V., Thomsson, K.A., and Hansson, G.C. (2009) Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein. J. Proteome Res, 8, 3549-3557
173. Holmén Larsson, J. M. Karlsson, H., Sjövall, H. and Hansson, G. C. (2009) A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn, Glycobiology, 19, 756-766.
172. Backstrom M, Thomsson KA, Karlsson H, Hansson GC. (2008) Sensitive Liquid Chromatography-Electrospray Mass Spectrometry Allows for the Analysis of the O-Glycosylation of Immunoprecipitated Proteins from Cells or Tissues: Application to MUC1 Glycosylation in Cancer. J Proteome Res. 8, 538-545.
171. Sihlbom C, van Dijk Härd I, Lidell ME, Noll T, Hansson GC, Bäckström M. (2009) Localisation of O-glycans in MUC1 glycoproteins using electron-capture dissociation fragmentation mass spectrometry. Glycobiology, 19: 375-381.
170. Johansson, M.E.V., Phillipson, M., Petersson, J., Holm, L., Velcich, A. and Hansson, G.C. (2008) The inner of the two Muc2 mucin dependent mucus layers in colon is devoid of bacteria. Proc. Natl. Acad. Sci USA, 105, 15064-15069.
169. Phillipson, M., Johansson, M.E.V., Henriksnäs, J., Petersson, J., Gendler, S.J., Sandler, S., Persson, A.E.G., Hansson, G.C. and Holm, L (2008) The gastric mucus layers: constituents and regulation of accumulation. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G806 - G812.
168. Karlsson, H., Holmén Larsson, J. M. Thomsson, K.A., Härd, I., Bäckström, M., and Hansson, G. C. (2009) High-throughput and high-sensitivity nano-LC/MS and MS/MS for O-glycan profiling. Methods Mol. Biol. 534: 1-15.
167. Lidell, M., Bara, J. and Hansson, G.C. (2008) Mapping of the 45M1 epitope to the C-terminal cysteine-rich part of the human MUC5AC mucin. FEBS J. 275, 481-489.
166. Malmberg, E.K., Pelaseyed, T., Petersson, Å.C., Seidler, U.E., de Jonge, H., Riordan, J.R., and Hansson, G.C. (2008) The Transmembrane MUC17 Mucin C-terminus Binds to the Scaffold Protein PDZK1 that Stably Localizes it to the Enterocyte Apical Membrane in the Small Intestine. Biochem. J. 410, 283-289.
165. Lang, T., Hansson, G. C., and Samuelsson, T. (2007) Gel-forming mucins appeared early in metazoan evolution. Proc. Natl. Acad. Sci. USA, 104, 16209-16214.
164. Kadaja-Saarepuu, L., Laos S., Jääger, K., Viil, J., Balikova, A., Lõoke, M., Hansson, G. C., and Maimets, T. (2008) CD43 promotes cell growth and helps to evade FAS-mediated apoptosis in nonhematopoietic cancer cells lacking the tumor suppressors p53 or ARF. Oncogene, 27, 1705-1715.
163. Andersch-Björkman, Y, Thomsson, K. A., Holmén Larsson, J. M., Ekerhovd, E., and Hansson, G. C. (2007) Large-scale Identification of Proteins, Mucins and their O-glycosylation in the Endocervical Mucus during the Menstrual Cycle. Mol. Cell Proteomics 6, 708-716 (Impact: 9.9)
162. Braun, F.N. and Hansson, G.C. (2006) Internal repeat variability in mucin sequences. Biomacromolecules, 7, 3542-3543
161. Lang, T., Hansson, G.C., and Samuelsson, T. (2006) An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins. BMC Genomics 7, 97.
160. Lidell, M. and Hansson, G.C. (2006) Cleavage in the GDPH sequence of the C-terminal Cysteine-rich Domain of the Human MUC5AC mucin. Biochem. J. 399, 121-129.
159. Lidell, M., Moncada, D., Chadee, K., and Hansson, G.C. (2006) Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal part and dissolves the protective colonic mucus gel. Proc Natl Acad Sci USA, 103, 9298-9303.
158. Malmberg, E., Noaksson, K. A., Phillipson, M., Johansson, M.E.V., Hinojosa-Kurtzberg, M., Holm, L., Gendler, S.J. and Hansson, G.C. (2006) Increased levels of mucins in the cystic fibrosis mouse small intestine and modulator effects of the Muc1 mucin expression. Am. J. Physiol. Gastrointest. Liver Physiol. 291, G203-G210.
157. Sewell, R., Backstrom, M., Dalziel, M., Gschmeissner, S., Karlsson, H., Noll, T., Gatgens, J., Clausen, H., Hansson, G. C., Burchell, J., Taylor-Papadimitriou, J. (2006) The ST6GalNAc-I sialyltransferase localises throughout the Golgi and is responsible for the synthesis of the tumour associated sialyl Tn O-glycan in human breast cancer. J. Biol. Chem. 281, 3586-3594.
156. Laos, S., Baeckström, D., and Hansson, G.C. (2006) Inhibition of NF-?B activation and chemokine expression by the leukocyte glycoprotein CD43 in colon cancer cells. Int. J. Oncology, 28, 695-704.
155. Macao, B., Johansson, D. G. A., Hansson, G.C. and Härd, T. (2006) Auto-proteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin. Nature Structural Molecular Biology, 13, 71-76.
154. Hurd, E. A., Holmén, J. M., Hansson, G. C., and Domino,S. E. (2005) Gastrointestinal Mucins of Fut2 Null Mice Lack Terminal Fucosylation without Affecting Colonization by Candida albicans. Glycobiology, 15:1002-1007.
153. Rughetti, A., Pellicciotta, I., Biffoni, M., Backstrom, M., Link, T., Bennet, E. P., Clausen, H., Noll, T., Hansson, G. C., Burchell, J. M., Frati, L., Taylor-Papadimitriou, J., and Nuti, M. (2005) Recombinant Tumor-Associated MUC1 Glycoprotein Impairs the Differentiation and Function of Dendritic Cells. J. Immunol. 174, 7764-7772.
152R. Hansson, G.C. (2005) Biosynthesis and secretion of mucins, especially the MUC2 mucin, in relation to Cystic Fibrosis. Adv. Exp. Med. Biol., 558, 169-178.
151. Andersson, C.X., Fernandez-Rodriguez, J., Laos, S., Baeckström, D., Haass, C., and Hansson, G.C. (2005) Shedding and ?-Secretase mediated intramembrane proteolysis of the mucin-type molecule CD43. Biochem. J. 387, 377–384.
150. Olson,F. J., Bäckström, M., Karlsson, H., Burchell, J., and Hansson, G. C. (2005) A MUC1 tandem repeat reporter protein produced in CHO K1 cells has sialylated core 1 O-glycans and becomes more densely glycosylated if co-expressed with polypeptide-GalNAc-T4 transferase. Glycobiology, 15, 177-191 (published on line 2004).
149. Malmberg, E. K., Andersson, C. X., Gentzsch, M., Chen, J. H., Cui, L., Hansson, G. C., and Riordan, J. R. (2004) BCR (breakpoint cluster region) protein binds the membrane associated PDZ-domain proteins PDZK1 and Mint3. J. Cell Sci. 117, 5535-5541.
148. Holmén, J., Karlsson, N.G., Abdullah, L. H., Randell, S. H., Sheehan, J. K., Hansson, G. C. and Davis, C. W. (2004) Mucins and their O-Glycans from Human Bronchial Epithelial Cell Cultures. Am. J. Physiol., Lung, Cell and Mol. Physiol. 287, L824-L834.
147R. Hansson, G.C. (2003) Glycomics - a complex challenge. The Biochemist 25, 11-13.
146. Lang, T., Alexandersson, M., Hansson, G. C., and Samuelsson, T. (2004) Bioinformatic identification of polymerizing and transmembrane mucins in the puffer fish Fugu rubripes. Glycobiology 14. 521-527.
145. Hattrup, C., Fernandez-Rodriguez, J., Schroder, J. A.., Hansson, G. C., and Gendler, S. J. (2004) MUC1 can interact with adenomatous polyposis coli in breast cancer. Biochem. Biophys. Res. Commun. 316, 364-369.
144. Andersson, C. X., Fernandez-Rodriguez, J., Laos, S. Sikut, R., Sikut, A. Baeckström, D. and Hansson, G. C. (2004) CD43 has a functional NLS, interacts with ß-catenin and affects gene expression. Biochem. Biophys. Res. Commun. 316, 12-17.
143. Link, T., Bäckstrom, M., Graham R., Essers, R., Zörner, K., Gätgens, J., Burchell, J., Taylor-Papadimitriou, J., Hansson, G. C. and Noll. T. (2004) Bioprocess development of the production of a recombinant MUC1 fusion protein expressed by CHO-K1-cells in protein-free medium. J. Biotechnology, 110, 51-62.
142. Sternberg, L. R., Byrd, J. C., Hansson, G. C., Liu, K.-F., Bresallier, R. S. (2004) Alternative splicing of the human MUC2 gene. Arch. Biochem. Biophys. 421, 21-33.
141. Angstrom, J., Larsson, T., Hansson, G. C., Karlsson, K.-A., and Henry, S. (2004) Default biosynthesis pathway for the blood-group related glycolipids in human small intestine as defiend by structural identification of linear and branched glycosylceramides in group 0 Le(a-b-) nonsecretor. Glycobiology, 14, 1-12.
140. Bäckström, M., Link, T., Olson, F.J., Karlsson, H., Graham, R., Burchell. J., Noll, T., Taylor-Papadimitriou, J., and Hansson, G.C. (2003) Recombinant MUC1 Mucin with a Breast Cancer-like O-glycosylation Produced in Large Amounts in CHO-K1 Cells Biochemical J. 376, 677-686.
139. Holmen, J.E., Olson, F.J., Karlsson, H. and Hansson, G.C. (2002) Mucin glycosylation alterations in mice due to intestinal infection by the parasite Nippostrongylus brasiliensis. Glycoconjugate J., 19, 67-75.
138. Lidell, M., Johansson, M.E.V., and Hansson, G.C. (2003) An autocatalytic cleavage in the Human MUC2 Mucin C-terminus occurs at the low pH of the late secretory pathway. J. Biol. Chem. 278, 13944-13951.
137. Hinojosa-Kurtzberg, M., Johansson, M. E.V., Madsen, C. S., Hansson, G. C., and Gendler, S. J. (2003) Novel MUC1 splice variants contribute to mucin over-expression in CFTR deficient mice. Am. J. Physiol. 284, G853-G862.
136. Fernandez-Rodriguez, J., Andersson, C.X., Laos, S., Baeckström, D. Sikut, A., Sikut, R., and Hansson, G.C. (2002) The Leukocyte Antigen CD43 is Expressed in Different Cell Lines of Non-Hematopoietic Origin. Tumor Biology, 23, 193-201
135. Fernandez-Rodriguez, J., Dwir, O., Alon, R. and Hansson, G.C. (2001, published 2003) Tumor cell MUC1 and CD43 are differently glycosylated with sialyl-Lewis a and x epitopes and show variable interactions with E-selectin under physiological flow conditions. Glycoconjugate J., 18, 925-930.
134. Lidell, M., Johansson, M. E. V., Asker, N., Gum, J. R., Kim, Y. S. and Hansson, G.C. (2003) The recombinant C-terminus of the human MUC2 mucin forms dimers in CHO cells and heterodimers with full-length MUC2 in LS 174T cells. Biochem. J., 372:335-345
133. Thomsson, K.A., Hinojosa-Kurtzberg, M., Axelsson, K.A. Domino, S.E. Lowe, J.B., Gendler, S.J., and Hansson, G.C. (2002) Intestinal Mucins from Cystic Fibrosis Mice show Increased Fucosylation due to an Induced Fuca1-2 Glycosyltransferase. Biochem. J., 367, 609–616
132. Godl, K., Johansson, M. E. V., Karlsson, H., Mörgelin, M., Lidell, M.E., Olson, F.J., Gum Jr., J.R., Young S. Kim, Y.S. and Hansson, G.C. (2002) The N-termini of the MUC2 mucin form trimers that are held together within a trypsin-resistant core fragment. J. Biol Chem., 277, 47248-47256
131. Olson, F.J., Johansson, M.E.V., Klinga-Levan,K., L., Bouhours, D., Enerbäck, Hansson, G.C. and Karlsson, N.G. (2002) Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during Nippostrongylus Braseliensis parasite infection. J. Biol. Chem. 277, 15044-15052
130. Thomsson, K. A., Prakobphol, A., Leffler, H., Reddy, M.S. Levine, M.J., Fisher, S.J. and Hansson, G.C. (2002) The Salivary Mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that are large and diverse. Glycobiology 12, 1-14.
129. Axelsson, M.A.B., Karlsson, N.G., Steel, D., Ouwendijk, J., Nilsson, T. and Hansson, G.C. (2001) Neutralization of the pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins. Glycobiology, 11, 633-644.
128. Thomsson, K.A., Karlsson, H. and Hansson, G.C. (2000) Sequencing of Sulfated Oligosaccharides from Mucins by Liquid Chromatography and Electrospray Ionization Tandem Mass Spectrometry. Anal. Chem., 72, 4543-4549.
127. Karlsson, N. G., Olson, F. J., Jovall, P.-Å., Andersch, Y., Enerbäck, L. and Hansson, G. C. (2000) Identification of transient glycosylation alterations of sialylated mucin oligosaccharides during the infection of the rat intestinal parasite Nippostrongylus brasiliensis. Biochemical J., 350, 805-814.
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