Welcome to the 2024 Homepage of the
MUCIN BIOLOGY GROUPS
(MUCINBIOLOGISKA GRUPPERNA)
THIS IS THE COMMON HOMEPAGE OF THE MUCIN BIOLOGY GROUPS
GUNNAR C. HANSSON Research Group
MALIN E.V. JOHANSSON Research Group
THAHER PELASEYED Research Group
GEORGE BIRCHENOUGH Research Group
SJOERD VAN DER POST Research Group
JENNY GUSTAFSSON Research Group
ANA S. LUIS Research Group
JESPER MAGNUSSON Clinical Research Group
KRISTINA JOHANSSON Research Group
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KAW - Knut and Alice Wallenberg Center, click to the right
Lederhausen's Center for Cystic Fibrosis Research, click to the right.
See also presentation (in Swedish) of mucus and CF at the Lederhausen homepage
 
NEWS APRIL 2024:
Mucins in Health and Disease Conference June 17th - June 20th 2024 in GOTHENBURG - The Conference is now overbooked and no more registration possible. The lucky ones are WELCOME!
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APRIL; ARTICLE ON GLP-1 together with Backheds group in Molecular Metabolism. Greiner, Thomas U., Koh, Ara, Peris, Eduard, Bergentall, Mattias, Johansson, Malin E. V., Hansson, Gunnar C., Drucker, Daniel J., and Backhed, Fredrik. GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota. Molecular Metabolism 83, 101924. 2024,
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APRIL 2024; Kristina Johansson received grants from Konsul Berghs Stiftelse
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FEBRUARY 2024; Elena Fekete recieved fellowships from EU Marie Curie
Kristina Johansson received grants from Magnus Bergvalls Stiftelse and Tore Nilssons Stiftelse
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DECEMBER 2023; Gunnar C. Hansson and Malin E.V. Johansson among the 1% MOST CITED scientists during 2023 in Cross-Fieled Sciences according to Clarivate ISI.
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NOVEMBER 30, Brendan Dolan, one year fellowship from Erica Lederhausen's Stiftelse
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NOVEMBER, NEW GRANTS: VETENSKAPSRADET/Swedish Research Council: George Birchenough: 1,200,000/y for three years; Gunnar C Hansson: 1,800,000/y for three years; CANCERFONDEN: Malin EV Johansson, 800,000/y for three years; HEART-LUNG FOUNDATION: Gunnar C. Hansson, 600,000/y for two years.
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NOVEMBER 10; ARTICLE Meike F Bos, Anna Ermund, Gunnar C Hansson, Joost de Graaf (2023)Goblet cell interactions reorient bundled mucus strands for efficient airway clearance PROC. NATL. ACAD. SCI. NEXUS Volume 2, Issue 11, November 2023, pgad388, https://doi.org/10.1093/pnasnexus/pgad388. View the full article at: https://academic.oup.com/pnasnexus/article/doi/10.1093/pnasnexus/pgad388/7405443?utm_source=authortollfreelink&utm_campaign=pnasnexus&utm_medium=email&guestAccessKey=6f63e31b-fe18-4f96-9e79-d3b810f8591c
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NOVEMBER; Kristina Johansson received grants from Jeanssons Stiftelse, Ake Wibergs Stiftelse and Gunvor och Josef Aners Stiftelse.
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OCTOBER 12; Elisabeth Nystrom and Kristina Johansson received the Elisabeth Bollan Linden stipend 2023.
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OCTOBER 6; Kristina Johansson received the Swedish Society for Allergology Award 2023 at Allergidagarna in Gothenburg, Sweden.
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AUGUST 27; Ana LUIS got awarded the 2023 International Glycoconjugate Organization Hakomori Young Glycoscientist Award at the Glyco26 Conference in Taipei, Taiwan.
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AUGUST 22; Published Article; Arnesen, H., Markussen, T., Birchenough, G., Birkeland, S., Nystrom, E. E. L., Hansson, G. C., Carlsen, H., and Boysen, P. (2023) Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse colons. Scientific Reports 13, 13701
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July. 13; REVIEW in CELL HOST & MICROBE; Ana S. Luis and Hansson, G. C. Intestinal mucus and their glycans - a habitat for thriving microbiota. CELL Host&Microbe 31, 1087-1100 (2023). View the full article at: https://www.sciencedirect.com/science/article/pii/S1931312823002196
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June; Krisitina JOHANSSON will start a Bitr. universitetslektor position at Krefting Research Institute at University of Gothenburg Sept. 1. She will be affiliated to the Mucin Biology Groups.
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June 16; Sofia JAVERFELT successfully defended her PhD thesis 'The functional role of MUC17-based glycocalyx'
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June; Thaher PELASEYED is now part of a new EU-grant Marie Sklodowska-Curie Actions Doctoral Networks that will pay for one PhD student over 4 years.
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June 5; Anna ERMUND was interviewed in Aftonladet, the largest newspaper in Sweden.
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May. 12; Malin E.V. JOHANSSON officially inaugated as a new FULL PROFESSOR of Biomedical Laboratory Science at University of Gothenburg at a ceremony at Konserthuset in Gothenburg. CONGRATULATIONS!
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May 5; Grete RABA successfully defender her thesis at Tallinn University of Technology in Estonia. Liisa Arika was one of the supervisors. CONGRATULATIONS!
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Apr. 9; Paper in NATURE Communications; Gallego, P., Garcia-Bonete, M. J., Trillo-Muyo, S., Recktenwald, C. V., Johansson, M. E. V., and Hansson, G. C. The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins. Nature Communications 14, 1969. View the full article at: https://doi.org/10.1038/s41467-023-37666-8
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Apr. 1; Paper in Science Advances; Bulck, C., Nystrom, E., Koudelka, T., Mannbar-Frahm, M., Andresen, G., Radhouani, M., Tran, F., Scharfenberg, F., Schrell, F., Armbrust, F., Dahlke, E., Zhao, B., Vervaeke, A., Theilig, F., Rosenstiel, P., Starki, P., Rosshart, S. P., FIckenscher, H., Tholey, A., Hansson, G. C., and Becker-Pauly, C. Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host microbiome homeostasis. Science Advances 9, eadf4055. 2023.
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Apr. 1; Paper in Respiratory Research; Rodriguez-Pineiro, Ana M., Jaudas, Florian, Klymiuk, Nikolai, Bahr, Andrea, Hansson, Gunnar C., and Ermund, Anna. Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets. Respiratory Research 24(1), 83. 2023.
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Apr. 2023; REVIEW in ESSAYS IN BIOCHEMISTRY; Raba, G. and Luis, A. S. Mucin utilization by gut microbiota: recent advances on characterization of key enzymes. Essays in Biochemistry , 67 (3): 345353.
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March 2023; Paper in CELL REPORTS; Birchenough, G. M. H., Schroeder, B. O., Sharba, S., Arike, L., Recktenwald, C. V., Puertolas-Balint, F., Subramani, M. V., Hansson, K. T., Yilmaz, B., Linden, S. K., Backhed, F., and Hansson, G. C. Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection. Cell Reports 42(2). 2-28-2023. . View the full article for free at: https://doi.org/10.1016/j.celrep.2023.112084
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Jan. 2023; REVIEW IN ESSAYS IN BIOCHEMISTRY; Luis, Ana S, Yates, Edwin A, and Cartmell, Alan. Functions and specificity of bacterial carbohydrate sulfatases targeting host glycans. Essays in Biochemistry 67(3), 429-442
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Article in English about the Mucin Biology Groups: https://akademiliv.se/en/2022/09/84914/
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The Mucin Sequence Database 2.2 was updated 2022 with the complete MUC3A and MUC3B sequences.
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SEE and LISTEN to us at:


RECENT PUBLICATIONS (2020-2023)
  • Bos, M.F., Ermund A., Hansson, G.C., and de Graaf, J. (2023) Goblet cell interactions reorient bundled mucus strands for efficient airway clearance. PNAS Nexus, 2, pgad388.
  • Arnesen, H., Markussen, T., Birchenough, G., Birkeland, S., Nystrom, E. E. L., Hansson, G. C., Carlsen, H., and Boysen, P. (2023) Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse colons. Scientific Reports 13, 13701.
  • REVIEW Luis, A.S. and Hansson, G.C. (2023) Intestinal mucus and their glycans: A habitat for thriving microbiota. Cell Host & Microbe 31, 1087-1100.
  • Bulck, C., Nystrom, E., Koudelka, T., Mannbar-Frahm, M., Andresen, G., Radhouani, M., Tran, F., Scharfenberg, F., Schrell, F., Armbrust, F., Dahlke, E., Zhao, B., Vervaeke, A., Theilig, F., Rosenstiel, P., Starki, P., Rosshart, S. P., FIckenscher, H., Tholey, A., Hansson, G. C., and Becker-Pauly, C. (2023) Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host microbiome homeostasis. Science Advances 9, eadf4055.
  • Rodriguez-Pineiro, A.M., Jaudas, F., Klymiuk, N., Bahr, A., Hansson, G.C., and Ermund, A. (2023) Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets. Respiratory Research 24(1), 83.
  • Gallego, P., Garcia-Bonete, M. J., Trillo-Muyo, S., Recktenwald, C. V., Johansson, M. E. V., and Hansson, G. C. (2023) The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins. Nature Communications, on-line.
  • Birchenough, G. M. H., Schroeder, B. O., Sharba, S., Arike, L., Recktenwald, C. V., Puertolas-Balint, F., Subramani, M. V., Hansson, K. T., Yilmaz, B., Linden, S. K., Backhed, F., and Hansson, G. C. Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection. Cell Reports 42(2). 2-28-2023
  • REVIEW Raba, G. and Luis, A. S. Mucin utilization by gut microbiota: recent advances on characterization of key enzymes. Essays in Biochemistry 67, 345-353. 2023
  • REVIEW Luis, Ana S, Yates, Edwin A, and Cartmell, Alan. Functions and specificity of bacterial carbohydrate sulfatases targeting host glycans. Essays in Biochemistry 67(3), 429-442. 2023
  • PERSPECTIVE Hansson, G. C. (2022) A Golgi oxygen 3 sensor controls intestinal mucin glycosylation. EMBO J., e2484.
  • *Hoang, O. N., *Ermund, A., Jaramillo, A. M., Fakih, D., French, C. B., Flores, J. R., Karmouty-Quintana, H., Magnusson, J. M., Fois, G., Fauler, M., Frick, M., Braubach, P., Hales, J. B., Kurten, R. C., Panettieri, R., Vergara, L., Ehre, C., Adachi, R., Tuvim, M. J., *Hansson, G. C., and *Dickey, B. F. Mucins (2022) MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules. Am. J. Resp. Crit. Care Med. 206, 1081-1095. *Equal contribution
  • REVIEW Ehre, C., Hansson, G. C., Thornton, D. J., Ostedgaard, and Ostedgaard, L. S. (2022) Mucus Aberrant Properties in CF: Insights from Cells and Animal Models. J. Cystic Fibrosis, 22, S23-S26.
  • Dolan, B., Ermund, A., Martinez-Abad, B., Johansson, M. E.V. and Hansson, G. C. (2022) Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. Science Signaling, 15, eabl5848
  • Lang, Tiange and Pelaseyed, Thaher. (2022) Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7. PLoS ONE 17, e0275671. 10-18-2022
  • REVIEW Gustafsson, J. K. and Johansson, M. E. V. (2022( The role of goblet cells and mucus in intestinal homeostasis. Nature Reviews Gastroenterology & Hepatology 19, 785-803.
  • REVIEW Suriano, F., Nystrom, E. E. L., Sergi, D., and Gustafsson, J. K. (2022) Diet, microbiota, and the mucus layer: The guardians of our health. Frontiers Immmunol. DOI 10.3389/fimmu.2022.953196.
  • PERSPECTIVE Hansson, G. C. (2022) A Golgi oxygen 3 sensor controls intestinal mucin glycosylation. EMBO J., e2484.
  • REVIEW Ehre, C., Hansson, G. C., Thornton, D. J., Ostedgaard, and Ostedgaard, L. S. (2022) Mucus Aberrant Properties in CF: Insights from Cells and Animal Models. J. Cystic Fibrosis, on-line.
  • PERSPECTIVE Johansson, M. E. V. and Hansson, G. C. (2022) Goblet cells need some stress. J. Clin. Invest. 132 (17), e162030.
  • Hoang, Oanh N., Ermund, Anna, Jaramillo, Ana M., Fakih, Dalia, French, Cory B., Flores, Jose R., Karmouty-Quintana, Harry, Magnusson, Jesper M., Fois, Giorgio, Fauler, Michael, Frick, Manfred, Braubach, Peter, Hales, Joshua B., Kurten, Richard C., Panettieri, Reynold, Vergara, Leoncio, Ehre, Camille, Adachi, Roberto, Tuvim, Michael J., Hansson, Gunnar C., and Dickey, Burton F. (2022) Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules. Am.J.Resp.Crit.Care Med. 206, 1081-1095.
  • Luis, Ana S., Basle, Arnaud, Byrne, Dominic P., Wright, Gareth S. A., London, James A., Jin, Chunsheng, Karlsson, Niclas G., Hansson, Gunnar C., Eyers, Patrick A., Czjzek, Mirjam, Barbeyron, Tristan, Yates, Edwin A., Martens, Eric C., and Cartmell, Alan. (2022) Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. Nature Chemical Biology 18, 841-849.
  • Sharpen, J. D. A., Dolan, B., Nystrom, E. E. L., Birchenough, G. M. H., Arike, L., Martinez-Abad, B., Johansson, M. E. V., Hansson, G. C. and Recktenwald, C. V. (2022) Transglutaminase 3 crosslinks the secreted MUC2 mucin and stabilizes the colonic mucus layer. Nature Communications, 13, 45.
  • Dolan, B. and Hansson, G. C. (2022) Mucins. Encyclopedia in Cell Biology 2d, Encyclopedia in Cell Biology. In press.
  • Ermund, A., Meiss, L. N., Dolan, B., Jaudas, F., Ewaldsson, L., Bahr, A., Klymiuk, N., and Hansson, G. C. (2021) Mucus threads from surface goblet cells clear particles from the airways. Respiratory Research 22(1), 303.
  • Sheikh, A., Wangdi, T., Vickers, T. J., Aaron, B., Palmer, M., Miller, M. J., Kim, S., Herring, C., Simoes, R., Crainic, J. A., Gildersleeve, J. C., van der Post, S., Hansson, G. C., and Fleckenstein, J. M. (2021) Enterotoxigenic Escherichia coli degrades the host MUC2 mucin barrier to facilitate critical pathogen-enterocyte interactions in human small intestine. Infection and Immunity, 90, e00572-21.
  • Luis, A. S., Jin, C., Pereira, G., Glowaki, R., Gugel, S., Sing, S., Byrne, D. P., Pudlo, N., London, J., Basle, A., Reihill, M., Oscarsson, S., Karlsson, N. G., Eyres, P., Czjzek, M., Michel, G., Barbeyron, T., Yates, E. A., Hansson, G. C., and Martens, E. C. (2021) A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium. Nature 598, 332-337.
  • Gustafsson, Jenny K., Davis, Jazmyne E., Rappai, Tracy, McDonald, Keely G., Kulkarni, Devesha H., Knoop, Kathryn A., Hogan, Simon P., Fitzpatrick, James AJ, Lencer, Wayne I., and Newberry, Rodney D. (2021) Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis. eLife 10, e67292.
  • Nonnecke, Eric B., Castillo, Patricia A., Dugan, Amanda E., Almalki, Faisal, Underwood, Mark A., De La Motte, Carol A., Yuan, Weirong, Lu, Wuyuan, Shen, Bo, Johansson, Malin E. V., Kiessling, Laura L., Hollox, Edward J., Lonnerdal, Bo, and Bevins, Charles L. (2021) Human intelectin-1 (ITLN1) genetic variation and intestinal expression. Scientific Reports 11(1), 12889.
  • Ehrencrona, E., van der Post, S., Gallego, P., Recktenwald, C. V., Rodriguez-Pineiro, A. M., Garcia-Bonete, M. J., Trillo-Muyo, S., Backstrom, M., Hansson, G. C., and Johansson, M. E. V. (2021) The IgG Fc-binding protein FCGBP is secreted with all GDPH sequences cleaved, but maintained by inter-fragment disulfide bonds. J. Biol. Chem. 297, 100871.
  • Nystrom, E. E. L., Martinez-Abad, B., Arike, L., Birchenough, G. M. H., Nonnecke, E. B., Castillo, P. A., Svensson, F., Bevins, C. L., Hansson, G. C., and Johansson, M. E. V. (2021) An intercrypt subpopulation of goblet cells are essential for colonic mucus barrier function. Science 372, 257.
  • Layunta, Elena, Javerfelt, Sofia, Dolan, Brendan, Arike, Liisa, and Pelaseyed, Thaher. (2021) IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning. Cell Reports 34(7), 108757.
  • van der Post, Sjoerd, Birchenough, George M. H., and Held, Jason M. (2021) NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation. Cell Reports 35(1), 108949.
  • Schroeder, B. O., Birchenough, G. M. H., Pradhan, M., Nystrom, E. E. L., Henricsson, M., Hansson, G. C., and Backhed, F. (2020) Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice. J. Biol. Chem. 296, 15712-15726.
  • REV: Hansson, G. C. (2020) Mucins and the Microbiome. Annual Rev. Biochem. 89, 769-793.
  • Arike, L., Hansson, G. C., and Recktenwald, C. V. (2020) Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps. Anal. Biochem. 597, 113668.
  • Fakih, D., Rodriguez Pineiro, A. M., Trillo-Muyo, S., Evans, C. M., Ermund, A., and Hansson, G. C. (2020) Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin. Am. J. Physiol. Lung Cell Mol. Physiol, 318, L1270-L1279.
  • Jabbar, K. S., Dolan, B., Eklund, L., Wising, C., Ermund, A., Johansson, A., Tornblom, H., Simren, M., and Hansson, G. C. (2020) Association between Brachyspira and irritable bowel syndrome with diarrhoea. Gut, on-line.
  • Pelaseyed, Thaher and Hansson, Gunnar C. (2020) Membrane mucins of the intestine at a glance. Journal of Cell Science 133(5), jcs240929.
  • Arike, Liisa, Seiman, Andrus, van der Post, Sjoerd, Rodriguez Pineiro, Ana M., Ermund, Anna, Schutte, Andre, Backhed, Fredrik, Johansson, Malin E. V., and Hansson, Gunnar C. (2020) Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota. Cell Reports 30(4), 1077-1087.