| RECENT PUBLICATIONS (2020-2024) |
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Layunta, Elena, Javerfelt, Sofia, van de Koolwijk, Fleur C., Sivertsson, Molly, Dolan, Brendan, Arike, Liisa, Thulin, Sara I. M., Vallance, Bruce A., and Pelaseyed, Thaher. (2024) MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohns disease. JCI Insight, doi.org/10.1172/jci.insight.181481.
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Pashos, Alison R. S., Meyer, Anne R., Bussey-Sutton, Cameron, OConnor, Erin S., Coradin, Mariel, Coulombe, Marilyne, Riemondy, Kent A., Potlapelly, Sanjana, Strahl, Brian D., Hansson, Gunnar C., Dempsey, Peter J., and Brumbaugh, Justin. (2025) H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium. Nature Cell Biology, on-line, doi.org/10.1038/s41556-024-01580-y.
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REViEW Gustafsson, J. K. and Hansson, G. C. (2025) Immune Regulation of Goblet Cell - Mucus Function in Health and Disease. Annual Rev. Immunol. 43, on-line (doi.org/10.1146/annurev-immunol-101721-065224).
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Javerfelt, Sofia, Hellsen, Gustaf, Kaji, Izumi, Goldenring, James R., and Pelaseyed, Thaher. (2024) The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes. Biochemical Journal , BCJ20240204.
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Ehrencrona, E., Gallego, P., Trillo-Muyo, S., Garcia-Bonete, M. J., Recktenwald, C. V., Hansson, G. C., and Johansson, M. E. V. (2024) The FCGBP structure is formed as a disulfide mediated homodimer between its C-terminal domains. FEBS J., on-line, http://doi.org/10.1111/febs.17383.
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Philipson, E., Jabbar, K., Bratlie, S. O., Hansson, G. C., Persson, J., Vilhav, C., Wennerblom, J., Sadik, R., Naredi, P., Bourghardt Fagman, J., and Engstrom, C. (2024) Adjunct mucin biomarkers MUC2+MUC5AC and MUC5AC+PSCA in a clinical setting identify and may improve correct selection of high-risk pancreatic lesions for surgery. HPB. on-line https://doi.org/10.1016/j.hpb.2024.10.018
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Raba, G., Luis, A. S., Schneider, H., Morell, I., Jin, C., Adamsberg, S., Hansson, G. C., Adamsberg, K., and Arike, L. (2024) Metaproteomics reveal parallel utilization of colonic mucin glycans and dietary fibres by the human gut microbiota. iScience, 27, 110093.
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Ljungholm, Penny L., Ermund, Anna, Soderlund Garsveden, Molly M., Pettersson, Victor L., and Gustafsson, Jenny K. (2024) The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E2, while Cftr regulates de novo mucus release in response to carbamylcholine. Pflugers Archiv - European Journal of Physiology 476(8), 1209-1219. .
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Rajan , Anandi, Gallego , Pablo, Dolan , Brendan, Patel , Piyush, Dwibedi , Chinmay, Ana, S., Trillo, Muyo, Arike , Liisa, van, der Post, Simren , Magnus, and Pelaseyed , Thaher. (2024) BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during infection. Gut Microbes 16(1), 2409247.
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Paone, Paola, Latousakis, Dimitris, Terrasi, Romano, Vertommen, Didier, Jian, Ching, Borlandelli, Valentina, Suriano, Francesco, Johansson, Malin E. V., Puel, Anthony, Bouzin, Caroline, Delzenne, Nathalie M., Salonen, Anne, Juge, Nathalie, Florea, Bogdan I., Muccioli, Giulio G., Overkleeft, Herman, Van Hul, Matthias, and Cani, Patrice D. (2024) Human milk oligosaccharide a-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice. Gut 73(10), 1632.
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Schaus, S. R., Periera, G. V., Luis, A. S., Madlambayan, E., Ostrowski, M. P., Jin, C., Hansson, G. C., and Martens, E. C. (2024) Ruminococcus torques is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by Bacteroides thetaiotaomicron. mBio, 15, e00039-24.
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Recktenwald, C. V., Karlsson, G., Garcia-Bonete, M. J., Katona, G., Jensen, M., Lymer, R., Backstrom, M., Johansson, M. E. V., Hansson, G. C., and Trillo-Muyo, S. (2024) The structure of the second CysD domain of MUC2 and role in mucin organization by transglutaminase-based cross-linking. Cell Rep., 43, 114207.
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Greiner, T. U., Koh, A., Peris, E., Bergentall, M., Johansson, M. E. V., Hansson, G. C., Drucker, D. J., and Backhed, F. (2024) GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota. Molecular Metabolism 83, 101924.
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Bos, M.F., Ermund A., Hansson, G.C., and de Graaf, J. (2023) Goblet cell interactions reorient bundled mucus strands for efficient airway clearance. PNAS Nexus, 2, pgad388.
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Arnesen, H., Markussen, T., Birchenough, G., Birkeland, S., Nystrom, E. E. L., Hansson, G. C., Carlsen, H., and Boysen, P. (2023) Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse colons. Scientific Reports 13, 13701.
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REVIEW Luis, A.S. and Hansson, G.C. (2023) Intestinal mucus and their glycans: A habitat for thriving microbiota. Cell Host & Microbe 31, 1087-1100.
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Bulck, C., Nystrom, E., Koudelka, T., Mannbar-Frahm, M., Andresen, G., Radhouani, M., Tran, F., Scharfenberg, F., Schrell, F., Armbrust, F., Dahlke, E., Zhao, B., Vervaeke, A., Theilig, F., Rosenstiel, P., Starki, P., Rosshart, S. P., FIckenscher, H., Tholey, A., Hansson, G. C., and Becker-Pauly, C. (2023) Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host microbiome homeostasis. Science Advances 9, eadf4055.
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Rodriguez-Pineiro, A.M., Jaudas, F., Klymiuk, N., Bahr, A., Hansson, G.C., and Ermund, A. (2023) Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets. Respiratory Research 24(1), 83.
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Gallego, P., Garcia-Bonete, M. J., Trillo-Muyo, S., Recktenwald, C. V., Johansson, M. E. V., and Hansson, G. C. (2023) The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins. Nature Communications, on-line.
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Birchenough, G. M. H., Schroeder, B. O., Sharba, S., Arike, L., Recktenwald, C. V., Puertolas-Balint, F., Subramani, M. V., Hansson, K. T., Yilmaz, B., Linden, S. K., Backhed, F., and Hansson, G. C. Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection. Cell Reports 42(2). 2-28-2023
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REVIEW Raba, G. and Luis, A. S. Mucin utilization by gut microbiota: recent advances on characterization of key enzymes. Essays in Biochemistry 67, 345-353. 2023
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REVIEW Luis, Ana S, Yates, Edwin A, and Cartmell, Alan. Functions and specificity of bacterial carbohydrate sulfatases targeting host glycans. Essays in Biochemistry 67(3), 429-442. 2023
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PERSPECTIVE Hansson, G. C. (2022) A Golgi oxygen 3 sensor controls intestinal mucin glycosylation. EMBO J., e2484.
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*Hoang, O. N., *Ermund, A., Jaramillo, A. M., Fakih, D., French, C. B., Flores, J. R., Karmouty-Quintana, H., Magnusson, J. M., Fois, G., Fauler, M., Frick, M., Braubach, P., Hales, J. B., Kurten, R. C., Panettieri, R., Vergara, L., Ehre, C., Adachi, R., Tuvim, M. J., *Hansson, G. C., and *Dickey, B. F. Mucins (2022) MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules. Am. J. Resp. Crit. Care Med. 206, 1081-1095. *Equal contribution
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REVIEW Ehre, C., Hansson, G. C., Thornton, D. J., Ostedgaard, and Ostedgaard, L. S. (2022) Mucus Aberrant Properties in CF: Insights from Cells and Animal Models. J. Cystic Fibrosis, 22, S23-S26.
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Dolan, B., Ermund, A., Martinez-Abad, B., Johansson, M. E.V. and Hansson, G. C. (2022) Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. Science Signaling, 15, eabl5848
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Lang, Tiange and Pelaseyed, Thaher. (2022) Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7. PLoS ONE 17, e0275671. 10-18-2022
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REVIEW Gustafsson, J. K. and Johansson, M. E. V. (2022( The role of goblet cells and mucus in intestinal homeostasis. Nature Reviews Gastroenterology & Hepatology 19, 785-803.
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REVIEW Suriano, F., Nystrom, E. E. L., Sergi, D., and Gustafsson, J. K. (2022) Diet, microbiota, and the mucus layer: The guardians of our health. Frontiers Immmunol. DOI 10.3389/fimmu.2022.953196.
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PERSPECTIVE Hansson, G. C. (2022) A Golgi oxygen 3 sensor controls intestinal mucin glycosylation. EMBO J., e2484.
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REVIEW Ehre, C., Hansson, G. C., Thornton, D. J., Ostedgaard, and Ostedgaard, L. S. (2022) Mucus Aberrant Properties in CF: Insights from Cells and Animal Models. J. Cystic Fibrosis, on-line.
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PERSPECTIVE Johansson, M. E. V. and Hansson, G. C. (2022) Goblet cells need some stress. J. Clin. Invest. 132 (17), e162030.
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Hoang, Oanh N., Ermund, Anna, Jaramillo, Ana M., Fakih, Dalia, French, Cory B., Flores, Jose R., Karmouty-Quintana, Harry, Magnusson, Jesper M., Fois, Giorgio, Fauler, Michael, Frick, Manfred, Braubach, Peter, Hales, Joshua B., Kurten, Richard C., Panettieri, Reynold, Vergara, Leoncio, Ehre, Camille, Adachi, Roberto, Tuvim, Michael J., Hansson, Gunnar C., and Dickey, Burton F. (2022) Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules. Am.J.Resp.Crit.Care Med. 206, 1081-1095.
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Luis, Ana S., Basle, Arnaud, Byrne, Dominic P., Wright, Gareth S. A., London, James A., Jin, Chunsheng, Karlsson, Niclas G., Hansson, Gunnar C., Eyers, Patrick A., Czjzek, Mirjam, Barbeyron, Tristan, Yates, Edwin A., Martens, Eric C., and Cartmell, Alan. (2022) Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. Nature Chemical Biology 18, 841-849.
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Sharpen, J. D. A., Dolan, B., Nystrom, E. E. L., Birchenough, G. M. H., Arike, L., Martinez-Abad, B., Johansson, M. E. V., Hansson, G. C. and Recktenwald, C. V. (2022) Transglutaminase 3 crosslinks the secreted MUC2 mucin and stabilizes the colonic mucus layer. Nature Communications, 13, 45.
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Dolan, B. and Hansson, G. C. (2022) Mucins. Encyclopedia in Cell Biology 2d, Encyclopedia in Cell Biology. In press.
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Ermund, A., Meiss, L. N., Dolan, B., Jaudas, F., Ewaldsson, L., Bahr, A., Klymiuk, N., and Hansson, G. C. (2021) Mucus threads from surface goblet cells clear particles from the airways. Respiratory Research 22(1), 303.
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Sheikh, A., Wangdi, T., Vickers, T. J., Aaron, B., Palmer, M., Miller, M. J., Kim, S., Herring, C., Simoes, R., Crainic, J. A., Gildersleeve, J. C., van der Post, S., Hansson, G. C., and Fleckenstein, J. M. (2021) Enterotoxigenic Escherichia coli degrades the host MUC2 mucin barrier to facilitate critical pathogen-enterocyte interactions in human small intestine. Infection and Immunity, 90, e00572-21.
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Luis, A. S., Jin, C., Pereira, G., Glowaki, R., Gugel, S., Sing, S., Byrne, D. P., Pudlo, N., London, J., Basle, A., Reihill, M., Oscarsson, S., Karlsson, N. G., Eyres, P., Czjzek, M., Michel, G., Barbeyron, T., Yates, E. A., Hansson, G. C., and Martens, E. C. (2021) A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium. Nature 598, 332-337.
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Gustafsson, Jenny K., Davis, Jazmyne E., Rappai, Tracy, McDonald, Keely G., Kulkarni, Devesha H., Knoop, Kathryn A., Hogan, Simon P., Fitzpatrick, James AJ, Lencer, Wayne I., and Newberry, Rodney D. (2021) Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis. eLife 10, e67292.
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Nonnecke, Eric B., Castillo, Patricia A., Dugan, Amanda E., Almalki, Faisal, Underwood, Mark A., De La Motte, Carol A., Yuan, Weirong, Lu, Wuyuan, Shen, Bo, Johansson, Malin E. V., Kiessling, Laura L., Hollox, Edward J., Lonnerdal, Bo, and Bevins, Charles L. (2021) Human intelectin-1 (ITLN1) genetic variation and intestinal expression. Scientific Reports 11(1), 12889.
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Ehrencrona, E., van der Post, S., Gallego, P., Recktenwald, C. V., Rodriguez-Pineiro, A. M., Garcia-Bonete, M. J., Trillo-Muyo, S., Backstrom, M., Hansson, G. C., and Johansson, M. E. V. (2021) The IgG Fc-binding protein FCGBP is secreted with all GDPH sequences cleaved, but maintained by inter-fragment disulfide bonds. J. Biol. Chem. 297, 100871.
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Nystrom, E. E. L., Martinez-Abad, B., Arike, L., Birchenough, G. M. H., Nonnecke, E. B., Castillo, P. A., Svensson, F., Bevins, C. L., Hansson, G. C., and Johansson, M. E. V. (2021) An intercrypt subpopulation of goblet cells are essential for colonic mucus barrier function. Science 372, 257.
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Layunta, Elena, Javerfelt, Sofia, Dolan, Brendan, Arike, Liisa, and Pelaseyed, Thaher. (2021) IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning. Cell Reports 34(7), 108757.
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van der Post, Sjoerd, Birchenough, George M. H., and Held, Jason M. (2021) NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation. Cell Reports 35(1), 108949.
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Schroeder, B. O., Birchenough, G. M. H., Pradhan, M., Nystrom, E. E. L., Henricsson, M., Hansson, G. C., and Backhed, F. (2020) Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice. J. Biol. Chem. 296, 15712-15726.
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REV: Hansson, G. C. (2020) Mucins and the Microbiome. Annual Rev. Biochem. 89, 769-793.
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Arike, L., Hansson, G. C., and Recktenwald, C. V. (2020) Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps. Anal. Biochem. 597, 113668.
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Fakih, D., Rodriguez Pineiro, A. M., Trillo-Muyo, S., Evans, C. M., Ermund, A., and Hansson, G. C. (2020) Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin. Am. J. Physiol. Lung Cell Mol. Physiol, 318, L1270-L1279.
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Jabbar, K. S., Dolan, B., Eklund, L., Wising, C., Ermund, A., Johansson, A., Tornblom, H., Simren, M., and Hansson, G. C. (2020) Association between Brachyspira and irritable bowel syndrome with diarrhoea. Gut, on-line.
- Pelaseyed, Thaher and Hansson, Gunnar C. (2020) Membrane mucins of the intestine at a glance. Journal of Cell Science 133(5), jcs240929.
- Arike, Liisa, Seiman, Andrus, van der Post, Sjoerd, Rodriguez Pineiro, Ana M., Ermund, Anna, Schutte, Andre, Backhed, Fredrik, Johansson, Malin E. V., and Hansson, Gunnar C. (2020) Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota. Cell Reports 30(4), 1077-1087.
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