Mucin Biology Groups Welcome! Our Research Areas Mass Spectrometry All Members of the Groups Publications Equipment Support Links Contact and Map for Visits Open Positions   DATABASES Mucin Database version 2.2, Oct. 2022 Mucin Structures, Download .txt and change to .pdb and open in PyMOL or ChimeraX PROGRAMS: PTS-PRED: 3 files to download, link at bottom. Program written by Tore Samuelsson (tore.samuelsson@medkem.gu.se) <1>Mucin PTS domain prediction script (pts_dist.pl) in Perl for amino acid sequences <2>Required Perl module (read_fasta.pm) <3>Mucin PTS domain prediction script (pts_scan.pl) for nt sequences Download the PTS-PRED programs as one Zip file here	Welcome to the 2026 Homepage of the MUCIN BIOLOGY GROUPS (MUCINBIOLOGISKA GRUPPERNA) >INTERNATIONAL LEADER OF MUCUS AND MUCIN RESEARCH< THIS IS THE COMMON HOMEPAGE OF THE MUCIN BIOLOGY GROUPS GUNNAR C. HANSSON Research Group MALIN E.V. JOHANSSON Research Group THAHER PELASEYED Research Group GEORGE BIRCHENOUGH Research Group SJOERD VAN DER POST Research Group JENNY GUSTAFSSON Research Group ANA S. LUIS Research Group JESPER M. MAGNUSSON Clinical Research Group KRISTINA JOHANSSON Research Group ---------------------------------- ---------------------------------- MucoLife Therapeutics AB, click to the right Lederhausen's Center for Cystic Fibrosis Research, click to the right. See also presentation (in Swedish) of mucus and CF at the Lederhausen homepage   NEWS DURING 2026 TO NOVEMBER 2026: ---------------------------------- OCTOBER 2026 MALIN EV JOHANSSON got a grant of 5.4 MSEK for 4 years from VETENSKAPSRADET. ---------------------------------- MAJOR GRANTS OCTOBER 2026 MALIN EV JOHANSSON got a grant of 4.7 MSEK for a new confocal microscope and KRISTINA JOHANSSON got a grant of 1.7 MSEK for a preparative cell sorter, both from LUNDBERGs Stiftelse. CONGRATULATIONS!! ---------------------------------- GPS Scholar 2026: Gunnar C. Hansson Lifetime most cited researcher on 'MUCUS' and Gunnar C Hansson, Malin EV Johansson and Jenny Gustafsson are 1,2, and 3 are most cited last 5 years on 'MUCUS'. Malin EV Johansson is 2d and Gunnar C Hansson is 4th on Lifetime 'GOBLET CELL'. ---------------------------------- ARTICLE IN RESPIRATORY RESEARCH: Trillo-Muyo, S., Ermund, A., Dolan, B., Akyurek, L. M., Magnusson, J. M., and Hansson, G. C. A SNP altering the MUC5AC mucin structure is increased in idiopathic pulmonary fibrosis together with the MUC5B SNP. Respiratory Research 27, 304. 2026. doi.org/10.1186/s12931-026-03833-w ---------------------------------- ARTICLE IN PNAS: Buckley, David P., Akhtar, Marjahan, Thapa, Mahima, Schmitz, Aaron, Turner, Jackson, Vickers, Tim J., Khatoon, Nazia, Kaisar, M. Hasanul, Coggin, Jonathan A., Ganguli, Debayan, Sheikh, Alaullah, Laird, Renee M., Poly, Frederic, Porter, Chad K., Ruiz-Perez, Fernando, Miller, Mark J., Chowdhury, Fahima, Bhuiyan, Tafiqur R., Qadri, Firdausi, Trillo-Muyo, Sergio, Dolan, Brendan, van der Post, Sjoerd, Ellebedy, Ali, Berndsen, Zachary T., and Fleckenstein, James M. Human enterotoxigenic Escherichia coli (ETEC) infections elicit antibodies that broadly neutralize mucinases of pathogenic Escherichia coli and Shigella. Proceedings of the National Academy of Sciences 123(25), e2614012123. 2026. doi.org/10.1073/pnas.2614012123 ---------------------------------- ARTICLE IN MUCOSAL IMMUNOLOGY: Patil, Neeraj, Ambjornsson, Jonas, Kallin, Sofia, Malla, Duaa, Sayedali, Hiba, Akesson, Emilia, Radinger, Madeleine, Hansson, Gunnar C., and Johansson, Kristina. Dysregulated MUC5B and MUC5AC impair epithelial barrier function and alter granulocyte frequency and activation in the lung and distal sites. Mucosal Immunology 19, 100385. 2026.www.sciencedirect.com/science/article/pii/S1933021926000875 ---------------------------------- ARTICLE IN AMERICAN JOURNAL PHYSIOLOGY: Villanueva, Sandra, Hernandez-Rivas, Sebastian, Ermund, Anna, Dolan, Brendan, Hansson, Gunnar C., Catalan, Marcelo A., and Flores, Carlos A. The spatiotemporal distribution of Foxi1-expressing pulmonary ionocytes in the mouse airways. American Journal of Physiology-Cell Physiology 331(2), C281-C292. 2026. doi.org/10.1152/ajpcell.00233.2026 ---------------------------------- ARTICLE IN JOURNAL OF BIOLOGICAL CHEMISTRY: Pudlo, N. A., Pereira, G. l. V., Schaus, S. R., Yang, Q., Fuentes, J. J., Jin, C., Hein, R., Zhang, L., Terrapon, N., Lyssiotis, C. A., Schmidt, T. M., Hansson, G. C., Luis, A. S., and Martens, E. C. The butyrate-producing Gram-positive human gut bacterium, Hoskinsella mucinilytica, selectively targets host mucin N-acetylhexosamines. Journal of Biological Chemistry 302, 111371, 2026. www.sciencedirect.com/science/article/pii/S0021925826002413 ---------------------------------- ARTICLE IN BIOSCIENCE REPORTS: van de Koolwijk, Fleur-Claire and Pelaseyed, Thaher. MUC17 and the intestinal glycocalyx: structure, regulation, and barrier function in health and disease. Bioscience Reports 46(10), BSR20250123. 2026. www.sciencedirect.com/science/article/pii/S1931312825000563 ---------------------------------- ARTICLE IN NATURE MICROBIOLOGY: Dey, Debajit, Salman, Naba D., Tomlinson, Charles W. E., Jin, Chunsheng, Raba, Grete, Schaus, Sadie R., Nilsson, Marcus, McIver, Zak, Herman, Reyme, Simpkin, Adam, Davy, Matthew, Rigden, Daniel J., Czjzek, Mirjam, Byrne, Dominic P., Oltean, Mihai, Case, Alexander, Baumann, Christoph G., Wright, Gareth S. A., van der Post, Sjoerd, Yates, Edwin A., Martens, Eric C., Davey, Lauren, Luis, Ana S., and Cartmell, Alan. Unique adaptations in sulfatases underpin colonic mucin degradation by Akkermansia muciniphila. Nature Microbiology 11, 2525-2542, 2026.doi.org/10.1172/jci.insight.181481 ---------------------------------- ARTICLE IN NATURE GENETICS: Moksnes, Marta Riise, Coward, Eivind, Nethander, Maria, Dekkers, Koen, Grahnemo, Louise, Tornqvist, Anna E., Li, Lei, Lundmark, Per, Pertiwi, Kamalita, Baldanzi, Gabriel, Mjelle, Robin, Moll, Janne Marie, Eklund, Aron Charles, Nielsen, Henrik Bjorn, Svensson, Johan, Langhammer, Arnulf, Giskeodegard, Guro F., Brumpton, Ben, Hjort, Rebecka, Ness-Jensen, Eivind, Engstr+Śm, Gunnar, Pelaseyed, Thaher, Michaelsson, Karl, Orho-Melander, Marju, Fall, Tove, Hveem, Kristian, and Ohlsson, Claes. The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition. Nature Genetics .58, 530-539, 2026. doi.org/10.1038/s41588-026-02502-4 ---------------------------------- ARTCLES IN METHODS ENZYMOLOGY: Nystrom, Elisabeth E. L., Dolan, Brendan, Birchenough, George M. H., and Johansson, Malin E. V. Chapter Sixteen - Ex vivo imaging and enzymatic analysis of intestinal mucus. Malaker, Stacy A. Methods in Enzymology Mucins. 732, 541-568. 2026. Academic Press. ---------------------------------- ARTCLES IN METHODS ENZYMOLOGY: van de Koolwijk, Fleur Claire and Pelaseyed, Thaher. Glyco-TRAPP: A real-time glycocalyx permeability assay for assessing transmembrane mucin barrier function in live and fixed tissues. Methods in Enzymology. 732, 529-540. 2026. Academic Press ---------------------------------- NEW ARTICLE IN EUROPEAN RESPIRATORY JOURNAL OPEN RESEARCH: Arike, L., Johansson, K., Ermund, A., Greer, M., Pelaseyed, T., Westin, J., Hansson, G. C., and Magnusson, J. M. Proteomic analysis of bronchoalveolar lavage fluid after lung transplantation associates stable allograft function with less lung damage at 12 months. Eur.Resp.J.Open Res. 12, 00781-2025. 2026. doi.org/10.1183/23120541.00781-2025 ---------------------------------- ARTICLE PUBLISHED IN NATURE COMMUNICATIONS. Trillo-Muyo, S., Dolan, B., Svensson, F., Vickers, T. J., Arike, L., Garcia-Bonete, M. J., Gustafsson, J. K., Nielsen, M. I., Wandall, H. H., Fleckenstein, J. M., Hansson, G. C., and van der Post, S. EatA mediated degradation of intestinal mucus is species-specific and driven by MUC2 structural features. Nature Communications 17(1), 158. 2026. doi.org/10.1038/s41467-025-68037-0 ---------------------------------- APRIL 2026; CONGRATULATIONS TO JENNY GUSTAFSSON, APPOINTED AS UNIVERSITETSLEKTOR (Senior Lecturer) IN PHYSIOLOGY ---------------------------------- ARTICLE PUBLISHED IN AM. J. RESP. CELL MOL. BIOL. Hoang, Oanh N., Chan, Colin E., Brenner, Joshua M., Leza-Rincon, Denisse, Jaramillo, Ana M., Dolan, Brendan, Aziz, Adam W., Cardenas, Rodolfo A., Cardenas, Gerardo J., Galvez, Eduardo D., Hales, Joshua B., Nunez-Pena, Emilia S., Yang, Boxuan, Powell, Reid T., Vergara, Leoncio, Karmouty-Quintana, Harry, Magnusson, Jesper M., Hansson, Gunnar C., Adachi, Roberto, Dickinson, John D., Evans, Christopher M., Courson, Justin A., Burns, Alan R., Tuvim, Michael J., and Dickey, Burton F. Airway Secretory Cells Contain Both a Perinuclear Golgi Ribbon and Dispersed Golgi Satellites. Am.J.Resp.Cell.Mol Biol. doi.org/10.1093/ajrcmb/aanag018, on-line. 2-21-2026 ---------------------------------- JANUARY 2026: ELISABETH NYSTROM starts her own to MBG affiliated laboratory at KAROLINSKA INSTITUTET, Stockholm ---------------------------------- The Mucin Sequence Database 2.2 was updated 2022 with the complete MUC3A and MUC3B sequences. ---------------------------------- RECENT PUBLICATIONS (2023-2026) Buckley, David P., Akhtar, Marjahan, Thapa, Mahima, Schmitz, Aaron, Turner, Jackson, Vickers, Tim J., Khatoon, Nazia, Kaisar, M. Hasanul, Coggin, Jonathan A., Ganguli, Debayan, Sheikh, Alaullah, Laird, Renee M., Poly, Frederic, Porter, Chad K., Ruiz-Perez, Fernando, Miller, Mark J., Chowdhury, Fahima, Bhuiyan, Tafiqur R., Qadri, Firdausi, Trillo-Muyo, Sergio, Dolan, Brendan, van der Post, Sjoerd, Ellebedy, Ali, Berndsen, Zachary T., and Fleckenstein, James M. Human enterotoxigenic Escherichia coli (ETEC) infections elicit antibodies that broadly neutralize mucinases of pathogenic Escherichia coli and Shigella. Proceedings of the National Academy of Sciences 123(25), e2614012123. 2026. >li> van de Koolwijk, Fleur-Claire and Pelaseyed, Thaher. MUC17 and the intestinal glycocalyx: structure, regulation, and barrier function in health and disease. Bioscience Reports 46(10), BSR20250123. 2026. Dey, Debajit, Salman, Naba D., Tomlinson, Charles W. E., Jin, Chunsheng, Raba, Grete, Schaus, Sadie R., Nilsson, Marcus, McIver, Zak, Herman, Reyme, Simpkin, Adam, Davy, Matthew, Rigden, Daniel J., Czjzek, Mirjam, Byrne, Dominic P., Oltean, Mihai, Case, Alexander, Baumann, Christoph G., Wright, Gareth S. A., van der Post, Sjoerd, Yates, Edwin A., Martens, Eric C., Davey, Lauren, Luis, Ana S., and Cartmell, Alan. Unique adaptations in sulfatases underpin colonic mucin degradation by Akkermansia muciniphila. Nature Microbiology 11, 2525-2542. 2026. van de Koolwijk, Fleur Claire and Pelaseyed, Thaher. Glyco-TRAPP: A real-time glycocalyx permeability assay for assessing transmembrane mucin barrier function in live and fixed tissues. Methods in Enzymology. 732, 529-540. 2026 Nystrom, Elisabeth E. L., Dolan, Brendan, Birchenough, George M. H., and Johansson, Malin E. V. Chapter Sixteen - Ex vivo imaging and enzymatic analysis of intestinal mucus. Malaker, Stacy A. Methods in Enzymology. Mucins. 732, 541-568. 2026. Academic Press. Moksnes, Marta Riise, Coward, Eivind, Nethander, Maria, Dekkers, Koen, Grahnemo, Louise, Tornqvist, Anna E., Li, Lei, Lundmark, Per, Pertiwi, Kamalita, Baldanzi, Gabriel, Mjelle, Robin, Moll, Janne Marie, Eklund, Aron Charles, Nielsen, Henrik Bjorn, Svensson, Johan, Langhammer, Arnulf, Giskeodegard, Guro F., Brumpton, Ben, Hjort, Rebecka, Ness-Jensen, Eivind, Engstr+Śm, Gunnar, Pelaseyed, Thaher, Michaelsson, Karl, Orho-Melander, Marju, Fall, Tove, Hveem, Kristian, and Ohlsson, Claes. The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition. Nature Genetics 58, 530-539. 2026. van Rijn, Jorik M., Lopes, Ana C. C., Dienhart, Finja S. V., Ceylan, Merve, Trinks, Nora, Eriksson, Jens, Bergholtz, Alexandra, Ntokaki, Angelika, Hammar, Rebekkah, Sundbom, Magnus, Skogar, Martin, Graf, Wilhelm, Webb, Dominic Luc, Hellstrom, Per M., Artursson, Per, Pelaseyed, Thaher, Di Martino, Maria Letizia, and Sellin, Mikael E. Maturation of human intestinal epithelial cell layers fortifies the apical surface against Salmonella attack. Cell Reports 44(12), 116579. 2026 Villanueva, S., Hernandez-Rivas, S., Ermund, A., Dolan, B., Hansson, G. C., Catalan, M. A., and Flores, C. A. (2026) The spatiotemporal distribution of Foxi1-expressing pulmonary ionocytes in the mouse airways. American Journal of Physiology-Cell Physiology 331(2), C281-C292. Patil, N., Ambjornsson, J., Kallin, S., Malla, D., Sayedali, H., Akesson, E., Radinger, M., Hansson, G. C., and Johansson, K.. (2026) Dysregulated MUC5B and MUC5AC impair epithelial barrier function and alter granulocyte frequency and activation in the lung and distal sites. Mucosal Immunology 19, 100385. Trillo-Muyo, S., Ermund, A., Dolan, B., Akyurek, L. M., Magnusson, J. M., and Hansson, G. C. (2026) A SNP altering the MUC5AC mucin structure is increased in idiopathic pulmonary fibrosis. Resp. Res. 27, 304 Pudlo, N. A., Pereira, G. l. V., Schaus, S. R., Yang, Q., Fuentes, J. J., Jin, C., Hein, R., Zhang, L., Terrapon, N., Lyssiotis, C. A., Schmidt, T. M., Hansson, G. C., Luis, A. S., and Martens, E. C. (2026) The butyrate-producing Gram-positive human gut bacterium, Hoskinsella mucinilytica, selectively targets host mucin N-acetylhexosamines. J. Biol. Chem., 302, 111371. Hoang, Oanh N., Chan, Colin E., Brenner, Joshua M., Leza-Rincon, Denisse, Jaramillo, Ana M., Dolan, Brendan, Aziz, Adam W., Cardenas, Rodolfo A., Cardenas, Gerardo J., Galvez, Eduardo D., Hales, Joshua B., Nunez-Pena, Emilia S., Yang, Boxuan, Powell, Reid T., Vergara, Leoncio, Karmouty-Quintana, Harry, Magnusson, Jesper M., Hansson, Gunnar C., Adachi, Roberto, Dickinson, John D., Evans, Christopher M., Courson, Justin A., Burns, Alan R., Tuvim, Michael J., and Dickey, Burton F. Airway Secretory Cells Contain Both a Perinuclear Golgi Ribbon and Dispersed Golgi Satellites. Am.J.Resp.Cell.Mol Biol. doi.org/10.1093/ajrcmb/aanag018, on-line. 2-21-2026 Moksnes MR, Coward E, Nethander M, Dekkers K, Grahnemo L, Tornqvist AE, Li L, Lundmark P, Pertiwi K, Baldanzi G, Mjelle R, Moll JM, Eklund AC, Nielsen HB, Svensson J, Langhammer A, Giskeodegard GF, Brumpton B, Hjort R, Ness-Jensen E, Engstrom G, Pelaseyed T, Michaelsson K, Orho-Melander M, Fall T, Hveem K, Ohlsson C. The HUNT study identifies host genetic factors reproducibly associated with human gut microbiota composition. Nat Genet. 2026 Feb 13. doi: 10.1038/s41588-026-02502-4. Arike, L., Johansson, K., Ermund, A., Greer, M., Pelaseyed, T., Westin, J., Hansson, G. C., and Magnusson, J. M. Proteomic analysis of bronchoalveolar lavage fluid after lung transplantation associates stable allograft function with less lung damage at 12 months. Eur.Resp.J.Open Res. doi.org/10.1183/23120541.00781-2025, on-line, early view. 2026. Trillo-Muyo, Sergio, Dolan, Brendan, Svensson, Frida, Vickers, Tim J., Arike, Liisa, Garcia-Bonete, Maria Jose, Gustafsson, Jenny K., Nielsen, Mathias I., Wandall, Hans H., Fleckenstein, James M., Hansson, Gunnar C., and van der Post, Sjoerd. EatA mediated degradation of intestinal mucus is species-specific and driven by MUC2 structural features. Nature Communications 17(1), 158. 2026. Crawford, Conor J., Tomlinson, Charles W. E., Gunawan, Christian, Chen, Zongjia, Byrne, Dominic P., Darby, Cosette, Conti, Martina L. G., Larson, Tony, Luis, Ana S., Elli, Stefano, Yates, Edwin A., Bolam, David N., van der Post, Sjoerd, Williams, Spencer J., and Cartmell, Alan. Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism. Proceedings of the National Academy of Sciences 122(28), e2414331122. 7-15-2025 van Rijn JM, Lopes ACC, Dienhart FSV, Ceylan M, Trinks N, Eriksson J, Bergholtz A, Ntokaki A, Hammar R, Sundbom M, Skogar M, Graf W, Webb DL, Hellstrom PM, Artursson P, Pelaseyed T, Di Martino ML, Sellin ME. Maturation of human intestinal epithelial cell layers fortifies the apical surface against Salmonella attack. Cell Rep. 2025 Dec 23;44(12):116579. doi: 10.1016/j.celrep.2025.116579. Jakob, Manuel O., Sterczyk, Nele, Boulekou, Sotiria, Forster, Patrycja M., Barleben, Luisa, Alzain, Nadra, Jarick, Katja J., Pirzgalska, Roksana M., Raposo, Bruno, Hansson, Karl, Nystrom, Elisabeth E. L., Gondrand, Aurelia, Gonzalez-Acera, Miguel, Leclcre, Pierre S., Lapson, Marlen S., Poggenseier, Sarah, Deshpande, Divija, Velleman, Laura, Breiderhoff, Tilman, Brunkhorst, Max Felix, Schele, Anton M., Guerra, Gabriela M., Durek, Pawel, Mashreghi, Mir Farzin, Kohl, Anja A., Chu, Coco, Schneider, Christoph, Weidinger, Carl, Siegmund, Britta, Nordmann, Thierry M., Voehringer, David, Patankar, Jay V., Becker, Christoph, Birchenough, George M. H., Veiga-Fernandes, Henrique, Ronchi, Francesca, Kolesnichenko, Marina, Diefenbach, Andreas, and Klose, Christoph S. N. Enteric nervous system-derived VIP restrains differentiation of LGR5+ stem cells toward the secretory lineage impeding type 2 immune programs. Nature Immunology . 2025. Rowe, Matthew C., Pettersson, Victor L., Carbone, Simona Elisa, Gustafsson, Jenny K., and Poole, Daniel P. Neural Control of Goblet Cell Function in the Gastrointestinal Tract. American Journal of Physiology-Gastrointestinal and Liver Physiology . 8-18-2025 Gustafsson, Jenny K. and Knoop, Kathryn A. A Sex-specific Role for Goblet Cells and Mucus Homeostasis in the Intestine. Cellular and Molecular Gastroenterology and Hepatology , 101585. 2025. Tofthagen, Marthe, Jin, Chunsheng, Patel, Piyush, Sjoberg, Fei, Luis, Ana S., Maciej-Hulme, Marissa L., and Karlsson, Niclas G. Exploring the O-glycomic Degradome Using Natural Mucin Libraries. Brockhausen, Inka. Dynamics of Bacteria-Mucus Interactions. 145-156. 2025. New York, NY, Springer US. Johansson, Asa, Venkita Subramani, Mahadevan, Yilmaz, Bahtiyar, Nystrom, Elisabeth E. L., Layunta, Elena, Arike, Liisa, Sommer, Felix, Rosenstiel, Philip, Vereecke, Lars, Manneras-Holm, Louise, Wullaert, Andy, Pelaseyed, Thaher, Johansson, Malin E. V., and Birchenough, George M. H. Neonatal microbiota colonization primes maturation of goblet cell-mediated protection in the pre-weaning colon. The Journal of Experimental Medicine 222(8), e20241591. 5-5-2025 Azimzadeh, Philippe N., Birchenough, George M., Gualbuerto, Nathaniel C., Pinkner, Jerome S., Tamadonfar, Kevin O., Beatty, Wandy, Hannan, Thomas J., Dodson, Karen W., Ibarra, Enid C., Kim, Seonyoung, Schreiber, Henry L., Janetka, James W., Kau, Andrew L., Earl, Ashlee M., Miller, Mark J., Hansson, Gunnar C., and Hultgren, Scott J. Mechanisms of uropathogenic E. coli mucosal association in the gastrointestinal tract. Science Advances 11(5), eadp7066. 2025 Layunta, Elena, Javerfelt, Sofia, van de Koolwijk, Fleur C., Sivertsson, Molly, Dolan, Brendan, Arike, Liisa, Thulin, Sara I. M., Vallance, Bruce A., and Pelaseyed, Thaher. (2024) MUC17 is an essential small intestinal glycocalyx component that is disrupted in Crohns disease. JCI Insight, doi.org/10.1172/jci.insight.181481. Pashos, Alison R. S., Meyer, Anne R., Bussey-Sutton, Cameron, OConnor, Erin S., Coradin, Mariel, Coulombe, Marilyne, Riemondy, Kent A., Potlapelly, Sanjana, Strahl, Brian D., Hansson, Gunnar C., Dempsey, Peter J., and Brumbaugh, Justin. (2025) H3K36 methylation regulates cell plasticity and regeneration in the intestinal epithelium. Nature Cell Biology, on-line, doi.org/10.1038/s41556-024-01580-y. REViEW Gustafsson, J. K. and Hansson, G. C. (2025) Immune Regulation of Goblet Cell - Mucus Function in Health and Disease. Annual Rev. Immunol. 43, on-line (doi.org/10.1146/annurev-immunol-101721-065224). Javerfelt, Sofia, Hellsen, Gustaf, Kaji, Izumi, Goldenring, James R., and Pelaseyed, Thaher. (2024) The MYO1B and MYO5B motor proteins and the sorting nexin SNX27 regulate apical targeting of membrane mucin MUC17 in enterocytes. Biochemical Journal , BCJ20240204. Ehrencrona, E., Gallego, P., Trillo-Muyo, S., Garcia-Bonete, M. J., Recktenwald, C. V., Hansson, G. C., and Johansson, M. E. V. (2024) The FCGBP structure is formed as a disulfide mediated homodimer between its C-terminal domains. FEBS J., on-line, http://doi.org/10.1111/febs.17383. Philipson, E., Jabbar, K., Bratlie, S. O., Hansson, G. C., Persson, J., Vilhav, C., Wennerblom, J., Sadik, R., Naredi, P., Bourghardt Fagman, J., and Engstrom, C. (2024) Adjunct mucin biomarkers MUC2+MUC5AC and MUC5AC+PSCA in a clinical setting identify and may improve correct selection of high-risk pancreatic lesions for surgery. HPB. on-line https://doi.org/10.1016/j.hpb.2024.10.018 Raba, G., Luis, A. S., Schneider, H., Morell, I., Jin, C., Adamsberg, S., Hansson, G. C., Adamsberg, K., and Arike, L. (2024) Metaproteomics reveal parallel utilization of colonic mucin glycans and dietary fibres by the human gut microbiota. iScience, 27, 110093. Ljungholm, Penny L., Ermund, Anna, Soderlund Garsveden, Molly M., Pettersson, Victor L., and Gustafsson, Jenny K. (2024) The anion exchanger slc26a3 regulates colonic mucus expansion during steady state and in response to prostaglandin E2, while Cftr regulates de novo mucus release in response to carbamylcholine. Pflugers Archiv - European Journal of Physiology 476(8), 1209-1219. . Rajan , Anandi, Gallego , Pablo, Dolan , Brendan, Patel , Piyush, Dwibedi , Chinmay, Ana, S., Trillo, Muyo, Arike , Liisa, van, der Post, Simren , Magnus, and Pelaseyed , Thaher. (2024) BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during infection. Gut Microbes 16(1), 2409247. Paone, Paola, Latousakis, Dimitris, Terrasi, Romano, Vertommen, Didier, Jian, Ching, Borlandelli, Valentina, Suriano, Francesco, Johansson, Malin E. V., Puel, Anthony, Bouzin, Caroline, Delzenne, Nathalie M., Salonen, Anne, Juge, Nathalie, Florea, Bogdan I., Muccioli, Giulio G., Overkleeft, Herman, Van Hul, Matthias, and Cani, Patrice D. (2024) Human milk oligosaccharide a-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice. Gut 73(10), 1632. Schaus, S. R., Periera, G. V., Luis, A. S., Madlambayan, E., Ostrowski, M. P., Jin, C., Hansson, G. C., and Martens, E. C. (2024) Ruminococcus torques is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by Bacteroides thetaiotaomicron. mBio, 15, e00039-24. Recktenwald, C. V., Karlsson, G., Garcia-Bonete, M. J., Katona, G., Jensen, M., Lymer, R., Backstrom, M., Johansson, M. E. V., Hansson, G. C., and Trillo-Muyo, S. (2024) The structure of the second CysD domain of MUC2 and role in mucin organization by transglutaminase-based cross-linking. Cell Rep., 43, 114207. Greiner, T. U., Koh, A., Peris, E., Bergentall, M., Johansson, M. E. V., Hansson, G. C., Drucker, D. J., and Backhed, F. (2024) GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota. Molecular Metabolism 83, 101924. Bos, M.F., Ermund A., Hansson, G.C., and de Graaf, J. (2023) Goblet cell interactions reorient bundled mucus strands for efficient airway clearance. PNAS Nexus, 2, pgad388. Arnesen, H., Markussen, T., Birchenough, G., Birkeland, S., Nystrom, E. E. L., Hansson, G. C., Carlsen, H., and Boysen, P. (2023) Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse colons. Scientific Reports 13, 13701. REVIEW Luis, A.S. and Hansson, G.C. (2023) Intestinal mucus and their glycans: A habitat for thriving microbiota. Cell Host & Microbe 31, 1087-1100. Bulck, C., Nystrom, E., Koudelka, T., Mannbar-Frahm, M., Andresen, G., Radhouani, M., Tran, F., Scharfenberg, F., Schrell, F., Armbrust, F., Dahlke, E., Zhao, B., Vervaeke, A., Theilig, F., Rosenstiel, P., Starki, P., Rosshart, S. P., FIckenscher, H., Tholey, A., Hansson, G. C., and Becker-Pauly, C. (2023) Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host microbiome homeostasis. Science Advances 9, eadf4055. Rodriguez-Pineiro, A.M., Jaudas, F., Klymiuk, N., Bahr, A., Hansson, G.C., and Ermund, A. (2023) Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets. Respiratory Research 24(1), 83. Gallego, P., Garcia-Bonete, M. J., Trillo-Muyo, S., Recktenwald, C. V., Johansson, M. E. V., and Hansson, G. C. (2023) The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins. Nature Communications, on-line. Birchenough, G. M. H., Schroeder, B. O., Sharba, S., Arike, L., Recktenwald, C. V., Puertolas-Balint, F., Subramani, M. V., Hansson, K. T., Yilmaz, B., Linden, S. K., Backhed, F., and Hansson, G. C. Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection. Cell Reports 42(2). 2-28-2023 REVIEW Raba, G. and Luis, A. S. Mucin utilization by gut microbiota: recent advances on characterization of key enzymes. Essays in Biochemistry 67, 345-353. 2023 REVIEW Luis, Ana S, Yates, Edwin A, and Cartmell, Alan. Functions and specificity of bacterial carbohydrate sulfatases targeting host glycans. Essays in Biochemistry 67(3), 429-442. 2023 LINKS MUCIN BIOLOGY GROUP Prof. Gunnar C. Hansson MUCIN BIOLOGY GROUP Dr. Malin E.V. Johansson MUCIN BIOLOGY GROUP Dr. Thaher Pelaseyed MUCIN BIOLOGY GROUP Dr. George Birchenough MucoLife Therapeutics Associated with MBG Lederhausen's Center for Cystic Fibrosis Research