Welcome to the 2022 Homepage of the
MUCIN BIOLOGY GROUPS
(MUCINBIOLOGISKA GRUPPERNA)
THIS IS THE COMMON HOMEPAGE OF THE MUCIN BIOLOGY GROUPS
GUNNAR C. HANSSON GROUP
MALIN E.V. JOHANSSON GROUP
THAHER PELASEYED GROUP
GEORGE BIRCHENOUGH GROUP
SJOERD VAN DER POST GROUP
JENNY GUSTAFSSON GROUP
ANA LUIS GROUP
----------------------------------
PERSONAL POST-DOC POSITIONS: Karolina S. Jabbar, Kristina Johansson, and Elisabeth Nystrom
----------------------------------
KAW - Knut and Alice Wallenberg Center, click to the right
Lederhausen's Center for Cystic Fibrosis Research, click to the right.
See also presentation (in Swedish) of mucus and CF at the Lederhausen homepage
 
NEWS JANUARY 2022:
Ana Luis recieved a personal position for starting her own group from SSMF, Svenska Sallskapet for Medicinsk Forskning. She also recived a 4-year Starting Grant from the Swedish Research Coucil (Vetenskapsradet). She is now a PI within the constellation of Mucin Biology Groups.
----------------------------------
ADDITIONAL RECENT NEW GRANTS:
  • CANCERFONDEN: George Birchenough 800,000/year for 3 years (also Junior Research position)
  • ALF (VGR): Gunnar C. Hansson 1,000,000/year for 3 years; Malin Johansson 500,000/year for 3 years; Jenny Gustafsson 300,000/year
  • HJART-LUNG FONDEN: Gunnar C Hansson, 300,000/year for 2 years.
  • RIKSFORBUNDET CYSTISK FIBROS: Brendan Dolan, 174,000; Jenny Gustafsson, 100,000.
  • ----------------------------------
    Paper in NATURE; Luis, A. S., Jin, C., Pereira, G., Glowaki, R., Gugel, S., Sing, S., Byrne, D. P., Pudlo, N., London, J., Basl, A., Reihill, M., Oscarsson, S., Karlsson, N. G., Eyres, P., Czjzek, M., Michel, G., Barbeyron, T., Yates, E. A., Hansson, G. C., and Martens, E. C. A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium. Nature 598, 332-337. 2021
    ----------------------------------
    Paper in JOURNAL OF BIOLOGICAL CHEMISTRY, JBC; Ehrencrona, E., van der Post, S., Gallego, P., Recktenwald, C. V., Rodriguez-Pineiro, A. M., Garcia-Bonete, M. J., Trillo-Muyo, S., Backstrom, M., Hansson, G. C., and Johansson, M. E. V. The IgG Fc-binding protein FCGBP is secreted with all GDPH sequences cleaved, but maintained by inter-fragment disulfide bonds. Journal of Biological Chemistry 297, 100871. 2021
    ----------------------------------
    Paper in RESPIRATORY RESEARCH; Ermund, Anna, Meiss, Lauren N., Dolan, Brendan, Jaudas, Florian, Ewaldsson, Lars, B+hr, Andrea, Klymiuk, Nikolai, and Hansson, Gunnar C. Mucus threads from surface goblet cells clear particles from the airways. Respiratory Research 22(1), 303. 2021
    ----------------------------------
    Paper in eLIFE; Gustafsson, Jenny K., Davis, Jazmyne E., Rappai, Tracy, McDonald, Keely G., Kulkarni, Devesha H., Knoop, Kathryn A., Hogan, Simon P., Fitzpatrick, James AJ, Lencer, Wayne I., and Newberry, Rodney D. Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis. eLife 10, e67292. 2021 Highlighted in Science December 10, 2021
    ----------------------------------
    Paper in SCIENTIFIC REPORTS; Nonnecke, Eric B., Castillo, Patricia A., Dugan, Amanda E., Almalki, Faisal, Underwood, Mark A., De La Motte, Carol A., Yuan, Weirong, Lu, Wuyuan, Shen, Bo, Johansson, Malin E. V., Kiessling, Laura L., Hollox, Edward J., Lonnerdal, Bo, and Bevins, Charles L. Human intelectin-1 (ITLN1) genetic variation and intestinal expression. Scientific Reports 11(1), 12889. 2021
    ----------------------------------
    Paper in NATURE COMMUNICATIONS; Sharpen, J. D. A., Dolan, B., Nystrom, E. L. N., Birchenough, G. M. H., Arike, L., artinez-Abad, B., Johansson, M. E. V., Hansson, G. C., and Recktenwald, C. V. Transglutaminase 3 crosslinks the secreted MUC2 mucin and stabilizes the colonic mucus layer. Nature Commun. in press. 2022
    ----------------------------------
    Review in ENCYCLOPEDIA IN CELL BIOLOGY; Dolan, Brendan and Hansson, Gunnar C. Mucins. Encyclopedia in Cell Biology 2d, Encyclopedia in Cell Biology. in press 2022
    ----------------------------------
    Research Article in SCIENCE; Nystrom*, E. E. L., Martinez-Abad*, B., Arike, L., Birchenough, G. M. H., Nonnecke, E. B., Castillo, P. A., Svensson, F., Bevins, C. L., Hansson, G. C., and Johansson, M. E. V. (2021) An intercrypt subpopulation of goblet cells are essential for colonic mucus barrier function. Science 372, 257. April 16, 2021 *shared first author.
    >PRESS HERE FOR ACCESS TO REPRINT PDF
    >PRESS HERE ACCESS TO FULL TEXT
    ----------------------------------
    Gunnar C. Hansson was October 12, 2021, awarded The Royal Swedish King Medal 8th size with Serafimer ordens ribbon for his meritorious achievements in medical research from the Swedish Royal King and Queen.
    ----------------------------------
    ALL GRANTS for the Mucin Biology Groups the 2022 >20 MSEK/year include grants from K.-A. Wallenberg Foundation (2018-2023), National Institute of Health (NIH) (2016-2021), NIH (2020-2024), European Research Council (ERC) (2016-2021), Vetenskapsradet (Swedish Research Council) 2018-2022, several), Cancerfonden (several), ALF 2022-2024, several), Gates Foundation (2019-2022), Lederhausens Foundation for CF research, Hjart-lung fonden (2020-2024, several), Svenska Sallskapet Medicinsk Forskning (TP,AL), Wennergrensstiftelsen.
    ----------------------------------
    An updated Mucin Sequence Database 2.1 was opened March 20, 2019 with the complete MUC2 and MUC6 sequences still not updated in Uniprot.
    ----------------------------------
    Mucins in Health and Disease Conference
    The 'Cambridge' Mucin meeting previously held in Cambridge, UK, will now be held 27th July - 29th July 2022 in Utrecht, The Netherlands. There is a quick and easy transport from Schiphol International Airport. The meeting is organized by Malin EV Johansson, Thaher Pelaseyed, Chris Evans and Karin Strijbis. HOMEPAGE for program and Registration: https://www.mucinconference.com/
    ----------------------------------
    SEE and LISTEN to us at:
    • Due to the ongoing Corona pandemi, there are few and still uncertain on-site presentations planned
    • 17th ECFS Basic Science Conference in Albufeira, Portugal March 30 - April 02, 2022 (GCH)
    • EMBO | EMBL Symposium: Innate Immunity in Host-Pathogen Interactions. EMBL, Heidelberg, Germany July 17 - 20, 2022 (GCH)
    • MUCIN in HEALTH and DISEASE ("Cambridge meeting") Utrecht July 27-29, 2022 (ALL)


    RECENT PUBLICATIONS (2019-2022)
    • Sharpen, J. D. A., Dolan, B., Nystrom, E. E. L., Birchenough, G. M. H., Arike, L., Martinez-Abad, B., Johansson, M. E. V., Hansson, G. C. and Recktenwald, C. V. (2022) Transglutaminase 3 crosslinks the secreted MUC2 mucin and stabilizes the colonic mucus layer. Nature Communications, in press.
    • Dolan, B. and Hansson, G. C. (2022) Mucins. Encyclopedia in Cell Biology 2d, Encyclopedia in Cell Biology. In press.
    • Ermund, A., Meiss, L. N., Dolan, B., Jaudas, F., Ewaldsson, L., Bahr, A., Klymiuk, N., and Hansson, G. C. (2021) Mucus threads from surface goblet cells clear particles from the airways. Respiratory Research 22(1), 303.
    • Sheikh, A., Wangdi, T., Vickers, T. J., Aaron, B., Palmer, M., Miller, M. J., Kim, S., Herring, C., Simoes, R., Crainic, J. A., Gildersleeve, J. C., van der Post, S., Hansson, G. C., and Fleckenstein, J. M. (2021) Enterotoxigenic Escherichia coli degrades the host MUC2 mucin barrier to facilitate critical pathogen-enterocyte interactions in human small intestine. Infection and Immunity, on line.
    • Luis, A. S., Jin, C., Pereira, G., Glowaki, R., Gugel, S., Sing, S., Byrne, D. P., Pudlo, N., London, J., Basle, A., Reihill, M., Oscarsson, S., Karlsson, N. G., Eyres, P., Czjzek, M., Michel, G., Barbeyron, T., Yates, E. A., Hansson, G. C., and Martens, E. C. (2021) A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium. Nature 598, 332-337.
    • Gustafsson, Jenny K., Davis, Jazmyne E., Rappai, Tracy, McDonald, Keely G., Kulkarni, Devesha H., Knoop, Kathryn A., Hogan, Simon P., Fitzpatrick, James AJ, Lencer, Wayne I., and Newberry, Rodney D. (2021) Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis. eLife 10, e67292.
    • Nonnecke, Eric B., Castillo, Patricia A., Dugan, Amanda E., Almalki, Faisal, Underwood, Mark A., De La Motte, Carol A., Yuan, Weirong, Lu, Wuyuan, Shen, Bo, Johansson, Malin E. V., Kiessling, Laura L., Hollox, Edward J., Lonnerdal, Bo, and Bevins, Charles L. (2021) Human intelectin-1 (ITLN1) genetic variation and intestinal expression. Scientific Reports 11(1), 12889.
    • Ehrencrona, E., van der Post, S., Gallego, P., Recktenwald, C. V., Rodriguez-Pineiro, A. M., Garcia-Bonete, M. J., Trillo-Muyo, S., Backstrom, M., Hansson, G. C., and Johansson, M. E. V. (2021) The IgG Fc-binding protein FCGBP is secreted with all GDPH sequences cleaved, but maintained by inter-fragment disulfide bonds. J. Biol. Chem. 297, 100871.
    • Nystrom, E. E. L., Martinez-Abad, B., Arike, L., Birchenough, G. M. H., Nonnecke, E. B., Castillo, P. A., Svensson, F., Bevins, C. L., Hansson, G. C., and Johansson, M. E. V. (2021) An intercrypt subpopulation of goblet cells are essential for colonic mucus barrier function. Science 372, 257.
    • Layunta, Elena, Javerfelt, Sofia, Dolan, Brendan, Arike, Liisa, and Pelaseyed, Thaher. (2021) IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning. Cell Reports 34(7), 108757.
    • van der Post, Sjoerd, Birchenough, George M. H., and Held, Jason M. (2021) NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation. Cell Reports 35(1), 108949.
    • Schroeder, B. O., Birchenough, G. M. H., Pradhan, M., Nystrom, E. E. L., Henricsson, M., Hansson, G. C., and Backhed, F. (2020) Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice. J. Biol. Chem. 296, 15712-15726.
    • REV: Hansson, G. C. (2020) Mucins and the Microbiome. Annual Rev. Biochem. 89, 769-793.
    • Arike, L., Hansson, G. C., and Recktenwald, C. V. (2020) Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps. Anal. Biochem. 597, 113668.
    • Fakih, D., Rodriguez Pineiro, A. M., Trillo-Muyo, S., Evans, C. M., Ermund, A., and Hansson, G. C. (2020) Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin. Am. J. Physiol. Lung Cell Mol. Physiol, 318, L1270-L1279.
    • Jabbar, K. S., Dolan, B., Eklund, L., Wising, C., Ermund, A., Johansson, A., Tornblom, H., Simren, M., and Hansson, G. C. (2020) Association between Brachyspira and irritable bowel syndrome with diarrhoea. Gut, on-line.
    • Pelaseyed, Thaher and Hansson, Gunnar C. (2020) Membrane mucins of the intestine at a glance. Journal of Cell Science 133(5), jcs240929.
    • Arike, Liisa, Seiman, Andrus, van der Post, Sjoerd, Rodriguez Pineiro, Ana M., Ermund, Anna, Schutte, Andre, Backhed, Fredrik, Johansson, Malin E. V., and Hansson, Gunnar C. Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota. Cell Reports 30(4), 1077-1087.
    • Nystrom, E. E. L., Arike, L., Ehrencrona, E., Hansson, G. C., and Johansson, M. E. V. CLCA1 forms non-covalent oligomers in colonic mucus and has MUC2-processing properties. J. Biol. Chem., 294, 17075-17089, 2019
    • Volk, J.K., Abad, B.M., Nystrom, E. E. L., Svensson, F., Javerfelt, S., Hansson, G.C., Johansson, M. E. V., Birchenough, G. M. H. (2019) Inflammasome activity is not required for inner mucus layer formation or function in the distal colon. J. Exp. Med., 216, 2602-2618.
    • Schneider, H., Berger, E., Dolan, B., Martinez-Abad, B., Arike, L., Pelaseyed, T., and Hansson, G. C. (2019) The human transmembrane mucin MUC17 responds to TNF? by increased presentation at the plasma membrane. Biochem. J., 476, 2281-2295.
    • Blacher, Eran, Bashiardes, Stavros, Shapiro, Hagit, Rothschild, Daphna, Mor, Uria, Dori-Bachash, Mally, Kleimeyer, Christian, Moresi, Claudia, Harnik, Yotam, Zur, Maya, Zabari, Michal, Brik, Rotem Ben-Zeev, Kviatcovsky, Denise, Zmora, Niv, Cohen, Yotam, Bar, Noam, Levi, Izhak, Amar, Nira, Mehlman, Tevie, Brandis, Alexander, Biton, Inbal, Kuperman, Yael, Tsoory, Michael, Alfahel, Leenor, Harmelin, Alon, Schwartz, Michal, Israelson, Adrian, Arike, Liisa, Johansson, Malin E. V., Hansson, Gunnar C., Gotkine, Marc, Segal, Eran, and Elinav, Eran. (2019) Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature 572, 474-480.
    • Vega, G., Guequen, A., Johansson, M. E. V., Arike, L., Martinez-Abad, B., Nystrom, E. E. L., Scudieri, P., Pedemonte, N., Millar-Buchner, P., Philp, A. R., Galietta, L. J., Hansson, G. C., and Flores, C. A. (2019) Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium. Frontiers in Physiology 10, 694.
    • Furter, M., Sellin, M. E., Hansson, G. C., and Hardt, W. D. (2019) Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract. Cell Reports 27(9), 2665-2678.
    • REV: Hansson, G. C. (2019) Mucus and mucins in diseases of the intestinal and respiratory tracts. J. Internal Medicine 285, 479-490.
    • van der Post, S, Jabbar, K. S., Birchenough, G., Arike, L., Akhtar, N., Sjövall, H., Johansson, M. E. V., and Hansson, G.C. (2019) Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis. Gut, 68, 2142-2151