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Welcome to the 2024 Homepage of the |
MUCIN BIOLOGY GROUPS
(MUCINBIOLOGISKA GRUPPERNA) |
>INTERNATIONAL LEADER OF MUCUS AND MUCIN RESEARCH<
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THIS IS THE COMMON HOMEPAGE OF THE MUCIN BIOLOGY GROUPS |
GUNNAR C. HANSSON Research Group |
MALIN E.V. JOHANSSON Research Group |
THAHER PELASEYED Research Group |
GEORGE BIRCHENOUGH Research Group |
SJOERD VAN DER POST Research Group |
JENNY GUSTAFSSON Research Group
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ANA S. LUIS Research Group
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JESPER MAGNUSSON Clinical Research Group
KRISTINA JOHANSSON Research Group
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ELISABETH NYSTROM Research Group
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MucoLife Therapeutics AB, click to the right |
Lederhausen's Center for Cystic Fibrosis Research, click to the right.
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| See also presentation (in Swedish) of mucus and CF at the Lederhausen homepage |
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NEWS DECEMBER 2024: |
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DECEMBER 2024; George Birchenough got ERC CONSOLIDATOR GRANT!! FANTASTIC, CONGRTULATIONS!!
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DECEMBER 2024; Gunnar C. Hansson and Malin E.V. Johansson is once more among the 1% MOST CITED scientists during 2024 in Cross-Fieled Sciences according to Clarivate ISI. Third year in a row.
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NOVEMBER 2024; Anna Ermund and Kristina Johansson got GRANTs from HJART-LUNG FONDEN (400,000/year for 3 years to Anna and 700,000/year for 3 years to Kristina). CONGRATULATIONS!!
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NOVEMBER 2024; George Birchenough got 800 tSEK/year for two years from CANCERFONDEN; CONGRATULATION!! | |
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NOVEMBER 2024; ALF GRANTS for three years to Gunnar C. Hansson 1.25 MSEK/year, George Birchenough 750 tSEK/year, Jenny Gustafsson 400 tSEK/year, Jesper Magnusson 400 tSEK/year, and Kristina Johansson 400 tSEK/year. CONGRATULATIONS!! | |
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NOVEMBER 2024; Elisabeth Nystrom and Kristina Johansson got 4-year STARTING GRANTs from VETENSKAPSRADET (1.5 MSEK/year each). CONGRATULATIONS!! These are the FIFTH and SIXTH starting grants from Vetenskapsradet over the last years to the MBG constellation. FANTASTIC!
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NOVEMBER 2024; Jenny Gustafsson got project grant (1 MSEK/year x3) from VETENSKAPSRADET. CONGRATULATION!! | |
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OCTOBER 2024; Elisabeth Nystrom got the STARTING GRANT position from SSMF (Svenska Sallskapet Medicinsk Forskning) CONGRATULATIONS and welcome to a new PI, the 10th!! This is the third SSMF position to the MBG constellation.
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OCTOBER 2024; ARTICLE in GUT Microbes. Rajan , Anandi, Gallego , Pablo, Dolan , Brendan, Patel , Piyush, Dwibedi , Chinmay, Ana, S., Trillo, Muyo, Arike , Liisa, van, der Post, Simren , Magnus, and Pelaseyed , Thaher. BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during infection. Gut Microbes 16(1), 2409247.
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AUGUST 2024; ARTICLE in iScience in collaboration with Estonia and as part of Grete Raba's dissertation. Raba, G., Luis, A. S., Schneider, H., Morell, I., Jin, C., Adamsberg, S., Hansson, G. C., Adamsberg, K., and Arike, L. Metaproteomics reveal parallel utilization of colonic mucin glycans and dietary fibres by the human gut microbiota. iScience 27, 110093. 2024. | |
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AUGUST 2024; ARTICLE ON Ruminococcus bacteria in mBio in a collaboration with Eric Martens group. Schaus, S. R., Periera, G. V., Luis, A. S., Madlambayan, E., Ostrowski, M. P., Jin, C., Hansson, G. C., and Martens, E. C. Ruminococcus torques is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by Bacteroides thetaiotaomicron. mBio 15(8), e00039-24. 2024 | |
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MAY 2024; ARTICLE ON CysD domain in MUC2 in CELL Reports. Recktenwald, C. V., Karlsson, G., Garcia-Bonete, M. J., Katona, G., Jensen, M., Lymer, R., Backstrom, M., Johansson, M. E. V., Hansson, G. C., and Trillo-Muyo, S. The structure of the second CysD domain of MUC2 and role in mucin organization by transglutaminase-based cross-linking. Cell Reports 43, 114207. 2024 | |
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APRIL 2024; ARTICLE ON GLP-1 together with Backheds group in Molecular Metabolism. Greiner, Thomas U., Koh, Ara, Peris, Eduard, Bergentall, Mattias, Johansson, Malin E. V., Hansson, Gunnar C., Drucker, Daniel J., and Backhed, Fredrik. GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota. Molecular Metabolism 83, 101924. 2024, | |
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MAY 2024; Kristina Johansson received grants from Konsul Berghs Stiftelse and Clas Groschinskys Minnesfond
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FEBRUARY 2024; Elena Fekete recieved fellowships from EU Marie Curie
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Kristina Johansson received grants from Magnus Bergvalls Stiftelse and Tore Nilssons Stiftelse
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The Mucin Sequence Database 2.2 was updated 2022 with the complete MUC3A and MUC3B sequences.
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SEE and LISTEN to us at: |
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RECENT PUBLICATIONS (2020-2023) |
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Bos, M.F., Ermund A., Hansson, G.C., and de Graaf, J. (2023) Goblet cell interactions reorient bundled mucus strands for efficient airway clearance. PNAS Nexus, 2, pgad388.
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Arnesen, H., Markussen, T., Birchenough, G., Birkeland, S., Nystrom, E. E. L., Hansson, G. C., Carlsen, H., and Boysen, P. (2023) Microbial experience through housing in a farmyard-type environment alters intestinal barrier properties in mouse colons. Scientific Reports 13, 13701.
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REVIEW Luis, A.S. and Hansson, G.C. (2023) Intestinal mucus and their glycans: A habitat for thriving microbiota. Cell Host & Microbe 31, 1087-1100.
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Bulck, C., Nystrom, E., Koudelka, T., Mannbar-Frahm, M., Andresen, G., Radhouani, M., Tran, F., Scharfenberg, F., Schrell, F., Armbrust, F., Dahlke, E., Zhao, B., Vervaeke, A., Theilig, F., Rosenstiel, P., Starki, P., Rosshart, S. P., FIckenscher, H., Tholey, A., Hansson, G. C., and Becker-Pauly, C. (2023) Proteolytic processing of galectin-3 by meprin metalloproteases is crucial for host microbiome homeostasis. Science Advances 9, eadf4055.
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Rodriguez-Pineiro, A.M., Jaudas, F., Klymiuk, N., Bahr, A., Hansson, G.C., and Ermund, A. (2023) Proteome of airway surface liquid and mucus in newborn wildtype and cystic fibrosis piglets. Respiratory Research 24(1), 83.
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Gallego, P., Garcia-Bonete, M. J., Trillo-Muyo, S., Recktenwald, C. V., Johansson, M. E. V., and Hansson, G. C. (2023) The intestinal MUC2 mucin C-terminus is stabilized by an extra disulfide bond in comparison to von Willebrand factor and other gel-forming mucins. Nature Communications, on-line.
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Birchenough, G. M. H., Schroeder, B. O., Sharba, S., Arike, L., Recktenwald, C. V., Puertolas-Balint, F., Subramani, M. V., Hansson, K. T., Yilmaz, B., Linden, S. K., Backhed, F., and Hansson, G. C. Muc2-dependent microbial colonization of the jejunal mucus layer is diet sensitive and confers local resistance to enteric pathogen infection. Cell Reports 42(2). 2-28-2023
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REVIEW Raba, G. and Luis, A. S. Mucin utilization by gut microbiota: recent advances on characterization of key enzymes. Essays in Biochemistry 67, 345-353. 2023
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REVIEW Luis, Ana S, Yates, Edwin A, and Cartmell, Alan. Functions and specificity of bacterial carbohydrate sulfatases targeting host glycans. Essays in Biochemistry 67(3), 429-442. 2023
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PERSPECTIVE Hansson, G. C. (2022) A Golgi oxygen 3 sensor controls intestinal mucin glycosylation. EMBO J., e2484.
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*Hoang, O. N., *Ermund, A., Jaramillo, A. M., Fakih, D., French, C. B., Flores, J. R., Karmouty-Quintana, H., Magnusson, J. M., Fois, G., Fauler, M., Frick, M., Braubach, P., Hales, J. B., Kurten, R. C., Panettieri, R., Vergara, L., Ehre, C., Adachi, R., Tuvim, M. J., *Hansson, G. C., and *Dickey, B. F. Mucins (2022) MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules. Am. J. Resp. Crit. Care Med. 206, 1081-1095. *Equal contribution
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REVIEW Ehre, C., Hansson, G. C., Thornton, D. J., Ostedgaard, and Ostedgaard, L. S. (2022) Mucus Aberrant Properties in CF: Insights from Cells and Animal Models. J. Cystic Fibrosis, 22, S23-S26.
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Dolan, B., Ermund, A., Martinez-Abad, B., Johansson, M. E.V. and Hansson, G. C. (2022) Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. Science Signaling, 15, eabl5848
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Lang, Tiange and Pelaseyed, Thaher. (2022) Discovery of a MUC3B gene reconstructs the membrane mucin gene cluster on human chromosome 7. PLoS ONE 17, e0275671. 10-18-2022
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REVIEW Gustafsson, J. K. and Johansson, M. E. V. (2022( The role of goblet cells and mucus in intestinal homeostasis. Nature Reviews Gastroenterology & Hepatology 19, 785-803.
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REVIEW Suriano, F., Nystrom, E. E. L., Sergi, D., and Gustafsson, J. K. (2022) Diet, microbiota, and the mucus layer: The guardians of our health. Frontiers Immmunol. DOI 10.3389/fimmu.2022.953196.
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PERSPECTIVE Hansson, G. C. (2022) A Golgi oxygen 3 sensor controls intestinal mucin glycosylation. EMBO J., e2484.
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REVIEW Ehre, C., Hansson, G. C., Thornton, D. J., Ostedgaard, and Ostedgaard, L. S. (2022) Mucus Aberrant Properties in CF: Insights from Cells and Animal Models. J. Cystic Fibrosis, on-line.
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PERSPECTIVE Johansson, M. E. V. and Hansson, G. C. (2022) Goblet cells need some stress. J. Clin. Invest. 132 (17), e162030.
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Hoang, Oanh N., Ermund, Anna, Jaramillo, Ana M., Fakih, Dalia, French, Cory B., Flores, Jose R., Karmouty-Quintana, Harry, Magnusson, Jesper M., Fois, Giorgio, Fauler, Michael, Frick, Manfred, Braubach, Peter, Hales, Joshua B., Kurten, Richard C., Panettieri, Reynold, Vergara, Leoncio, Ehre, Camille, Adachi, Roberto, Tuvim, Michael J., Hansson, Gunnar C., and Dickey, Burton F. (2022) Mucins MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules. Am.J.Resp.Crit.Care Med. 206, 1081-1095.
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Luis, Ana S., Basle, Arnaud, Byrne, Dominic P., Wright, Gareth S. A., London, James A., Jin, Chunsheng, Karlsson, Niclas G., Hansson, Gunnar C., Eyers, Patrick A., Czjzek, Mirjam, Barbeyron, Tristan, Yates, Edwin A., Martens, Eric C., and Cartmell, Alan. (2022) Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. Nature Chemical Biology 18, 841-849.
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Sharpen, J. D. A., Dolan, B., Nystrom, E. E. L., Birchenough, G. M. H., Arike, L., Martinez-Abad, B., Johansson, M. E. V., Hansson, G. C. and Recktenwald, C. V. (2022) Transglutaminase 3 crosslinks the secreted MUC2 mucin and stabilizes the colonic mucus layer. Nature Communications, 13, 45.
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Dolan, B. and Hansson, G. C. (2022) Mucins. Encyclopedia in Cell Biology 2d, Encyclopedia in Cell Biology. In press.
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Ermund, A., Meiss, L. N., Dolan, B., Jaudas, F., Ewaldsson, L., Bahr, A., Klymiuk, N., and Hansson, G. C. (2021) Mucus threads from surface goblet cells clear particles from the airways. Respiratory Research 22(1), 303.
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Sheikh, A., Wangdi, T., Vickers, T. J., Aaron, B., Palmer, M., Miller, M. J., Kim, S., Herring, C., Simoes, R., Crainic, J. A., Gildersleeve, J. C., van der Post, S., Hansson, G. C., and Fleckenstein, J. M. (2021) Enterotoxigenic Escherichia coli degrades the host MUC2 mucin barrier to facilitate critical pathogen-enterocyte interactions in human small intestine. Infection and Immunity, 90, e00572-21.
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Luis, A. S., Jin, C., Pereira, G., Glowaki, R., Gugel, S., Sing, S., Byrne, D. P., Pudlo, N., London, J., Basle, A., Reihill, M., Oscarsson, S., Karlsson, N. G., Eyres, P., Czjzek, M., Michel, G., Barbeyron, T., Yates, E. A., Hansson, G. C., and Martens, E. C. (2021) A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium. Nature 598, 332-337.
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Gustafsson, Jenny K., Davis, Jazmyne E., Rappai, Tracy, McDonald, Keely G., Kulkarni, Devesha H., Knoop, Kathryn A., Hogan, Simon P., Fitzpatrick, James AJ, Lencer, Wayne I., and Newberry, Rodney D. (2021) Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis. eLife 10, e67292.
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Nonnecke, Eric B., Castillo, Patricia A., Dugan, Amanda E., Almalki, Faisal, Underwood, Mark A., De La Motte, Carol A., Yuan, Weirong, Lu, Wuyuan, Shen, Bo, Johansson, Malin E. V., Kiessling, Laura L., Hollox, Edward J., Lonnerdal, Bo, and Bevins, Charles L. (2021) Human intelectin-1 (ITLN1) genetic variation and intestinal expression. Scientific Reports 11(1), 12889.
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Ehrencrona, E., van der Post, S., Gallego, P., Recktenwald, C. V., Rodriguez-Pineiro, A. M., Garcia-Bonete, M. J., Trillo-Muyo, S., Backstrom, M., Hansson, G. C., and Johansson, M. E. V. (2021) The IgG Fc-binding protein FCGBP is secreted with all GDPH sequences cleaved, but maintained by inter-fragment disulfide bonds. J. Biol. Chem. 297, 100871.
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Nystrom, E. E. L., Martinez-Abad, B., Arike, L., Birchenough, G. M. H., Nonnecke, E. B., Castillo, P. A., Svensson, F., Bevins, C. L., Hansson, G. C., and Johansson, M. E. V. (2021) An intercrypt subpopulation of goblet cells are essential for colonic mucus barrier function. Science 372, 257.
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Layunta, Elena, Javerfelt, Sofia, Dolan, Brendan, Arike, Liisa, and Pelaseyed, Thaher. (2021) IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning. Cell Reports 34(7), 108757.
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van der Post, Sjoerd, Birchenough, George M. H., and Held, Jason M. (2021) NOX1-dependent redox signaling potentiates colonic stem cell proliferation to adapt to the intestinal microbiota by linking EGFR and TLR activation. Cell Reports 35(1), 108949.
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Schroeder, B. O., Birchenough, G. M. H., Pradhan, M., Nystrom, E. E. L., Henricsson, M., Hansson, G. C., and Backhed, F. (2020) Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice. J. Biol. Chem. 296, 15712-15726.
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REV: Hansson, G. C. (2020) Mucins and the Microbiome. Annual Rev. Biochem. 89, 769-793.
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Arike, L., Hansson, G. C., and Recktenwald, C. V. (2020) Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps. Anal. Biochem. 597, 113668.
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Fakih, D., Rodriguez Pineiro, A. M., Trillo-Muyo, S., Evans, C. M., Ermund, A., and Hansson, G. C. (2020) Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin. Am. J. Physiol. Lung Cell Mol. Physiol, 318, L1270-L1279.
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Jabbar, K. S., Dolan, B., Eklund, L., Wising, C., Ermund, A., Johansson, A., Tornblom, H., Simren, M., and Hansson, G. C. (2020) Association between Brachyspira and irritable bowel syndrome with diarrhoea. Gut, on-line.
- Pelaseyed, Thaher and Hansson, Gunnar C. (2020) Membrane mucins of the intestine at a glance. Journal of Cell Science 133(5), jcs240929.
- Arike, Liisa, Seiman, Andrus, van der Post, Sjoerd, Rodriguez Pineiro, Ana M., Ermund, Anna, Schutte, Andre, Backhed, Fredrik, Johansson, Malin E. V., and Hansson, Gunnar C. (2020) Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota. Cell Reports 30(4), 1077-1087.
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