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| Welcome to the 2013 Homepage of the |
MUCIN BIOLOGY GROUP
(MUCINBIOLOGISKA GRUPPEN) |
| MBC - Mucus, Bacteria and Colitis SSF Center, click to the right |
| KAW - Knut and Alice Wallenberg Center, click to the right |
| Lederhausen's Center for Cystic Fibrosis Research, click to the right |
| at the |
| University of Gothenburg, Gothenburg, Sweden |
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| NEWS MARCH 2013 |
| PUBLICATION IN GUT (2013) on-line (http://gut.bmj.com/content/early/2013/02/19/gutjnl-2012-303207.full.pdf+html) |
Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis |
Malin E V Johansson, Jenny K Gustafsson, Jessica Holmén-Larsson, Karolina S Jabbar, Lijun Xia, Hua Xu, Fayez K Ghishan, Frederic A Carvalho, Andrew T Gewirtz, Henrik Sjövall, and Gunnar C Hansson
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PDF: http://gut.bmj.com/content/early/2013/02/19/gutjnl-2012-303207.full.pdf+html |
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| PUBLICATION IN Journal of Experimental Medicine (2012) 209, 1263-1272 |
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype |
Jenny K. Gustafsson, Anna Ermund, Daniel Ambort, Malin E.V. Johansson, Harriet E. Nilsson, Kaisa Thorell, Hans Hebert, Henrik Sjövall, and Gunnar C. Hansson |
ACCESS: http://jem.rupress.org/cgi/content/abstract/jem.20120562 |
For more information, see Lederhausen Center for CF Research |
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| PUBLICATION IN PROC. NATL. ACAD. SCI. USA |
Calcium and pH-dependent Packing and Release of the Gel-forming MUC2 Mucin |
Daniel Ambort, Malin E. V. Johansson, Jenny K. Gustafsson, Harriet E. Nilsson, Anna Ermund, Bengt R. Johansson, Philip Köck, Hans Hebert, and Gunnar C. Hansson |
OPEN ACCESS: http://www.pnas.org.ezproxy.ub.gu.se/content/early/2012/03/21/1120269109.abstract |
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| PUBLICATION IN PLOS ONE PlosONE 7: e41009. doi:10.1371/journal.pone.0041009 |
Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins. |
Malin E. V. Johansson |
OPEN ACCESS: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0041009 |
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Swedish Research Council |
| SEK 1,800,000 per year in 5 years |
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Torsten Söderbergs Stiftelse |
| SEK 2,000,000 |
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Lundbergs Stiftelse, Mass Spectrometer Q-Exactive |
| SEK 2,000,000 |
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| SEE and LISTEN to us at: |
- Johns Hopkins University, Physiology, Baltimore,MD., Mar 6, 2013
- North Western University, Chicago, IL., Mar 8, 2013
- Malin E.V. Johansson: Host-Pathogen Interactions” in Voss, Norway, March 13-15th 2013
- IBD Expert Forum, Krusenbergs herrgård, Mar 13-15, 2013
- European Cystic Fibrosis Basic Science Conference, Malaga, Spain, Mar 20-23, 2013
- Gordon Research Confence: Cilia, mucus and Mucociliary Interactions, Lucca, Italy April 7-12, 2013
- The underestimated role of epithelium in inflammation, Institute Pasteur, Paris, France, Apr 12, 2013
- Microbiota in Human Disease, Rome, Italy, May 3-4 2013
- FALK Symposium: Inflammatory Bowel Diseases:Microbiota versus Barrier, Stuttgart, June 7-8, 2013
- Mucin in Health and Disease 'Cambridge meeting', Cambridge, UK July 27-31, 2013
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| RECENT PUBLICATIONS (2012-) |
- Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., and Hansson, G. C. (2013) Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and in patients with ulcerative colitis. Gut on line.
- Bäckström, M., Ambort, D., Thomsson, E., Johansson, M. E. V., and Hansson, G. C. (2012) Increased Understanding of the Biochemistry and Biosynthesis of MUC2 and Other Gel-Forming Mucins Through the Recombinant Expression of Their Protein Domains. Mol Biotechnol. DOI 10.1007/s12033-012-9562-3.
- Pelaseyed, T., Zäch, M., Petersson, A. C., Svensson, F., Johansson, D. G., and Hansson, G. C. (2013) Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell protective device. FEBS J. on line.
- Arampatzidou, M., Schütte, A., Hansson, G.C., Saftig, P., Brix, K. (2012) Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon. Biol Chem. 393, 1391-1403
- Ambort, D., Johansson, M.E.V., Gustafsson, J.K., Ermund, A., and Hansson G.C. (2012) Perspectives on Mucus Properties and Formation - Lessons from the Biochemical World. Cold Spring Harbor Perspectives in Medicine. 2(11), on-line
- Carvalho, F. A, Koren, O., Goodrich, J. K., Johansson, M. E. V., Nalbantoglu, I., Aitken, J. D., Su, Y., Chassaing, B., Walters, W. A., Gonzlez, A., Clemente, J. C., Cullender, T. C., Barnich, N., Darfeuille-Michaud, A., Vijay-Kumar, M., Knight, R., Ley, R. E., and Gewirtz, A. T. (2012) Transient Inability to Manage Proteobacteria Promotes Chronic Gut Inflammation in TLR5-Deficient Mice. Cell Host & Microbe 12, 139-152
- Ambort, D. and Hansson, G.C. (2012) Reply to Verdugo: Mucins form highly organized supramolecular structures. Proc.Natl.Acad.Sci.U.S.A. 109, E2956-2957
- Thomsson, K.A., Holmén-Larsson, J., Ångström, J., Johansson, M.E.V., Xia, L., and Hansson, G.C. (2012) Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2. Glycobiology 22, 1128-1139
- Johansson, M.E.V. and Hansson, G.C. (2013) The goblet cell: a key player in ischemia-reperfusion injury. Gut 62, 188-189
- Gustafsson, J.K., Hansson, G. C., and Sjövall, H. (2012) Ulcerative colitis patients in remission have an altered secretory capacity in the proximal colon despite macroscopically normal mucosa. Neurogastroenterol Motil, 24, e381-e391
- Johansson, M.E.V. (2012) Fast Renewal of the Distal Colonic Mucus Layers by the Surface Goblet Cells as Measured by In Vivo Labeling of Mucin Glycoproteins. PlosONE 7: e41009. doi:10.1371/journal.pone.0041009
- Gustafsson, J.K., Ermund, A., Ambort, D., Johansson, M.E.V., Nilsson, H.E., Thorell, K., Hebert, H., Sjövall, H., and Hansson, G. C. (2012) Bicarbonate and functional CFTR channel are required for proper mucin secretion and link Cystic Fibrosis with its mucus phenotype. J. Exp. Med., 209, 1263-1272
- Ambort, D., Johansson, M. E. V., Gustafsson, J. K., Nilsson, H., Ermund, A., Johansson, B. R., Kock, P., Hebert, H., and Hansson, G. C. (2012) Calcium and pH-dependent Packing and Release of the Gel-forming MUC2 Mucin. Proc.Natl.Acad.Sci.U.S.A. 109, 5645-5650
- Rodriguez-Pineiro, A.M., van der Post, S., Johansson, M.E.V., Thomsson, K.A., Nesvizhskii, A.I., and Hansson, G.C. (2012) Proteomic study of the mucin granulae in an intestinal goblet cell model. J. Proteome Res. on line
- Johansson, M.E.V., Hansson, G.C. (2012) Preservation of Mucus in Histological Sections, Immunostaining of Mucins in Fixed Tissue, and Localization of Bacteria with FISH. Methods Mol. Biol. 842, 229-235
- Gustafsson, J.K., Sjövall, H., Hansson, G.C. (2012) Ex vivo measurements of mucus secretion by colon explants. Methods Mol. Biol. 842, 237-243
- Johansson, M.E.V., Hansson, G.C. (2012) Analysis of assembly of secreted mucins. Methods Mol. Biol. 842, 109-121
- Hansson, G.C. (2012) Role of mucus layers in gut infection and inflammation. Curr. Opinion Microbiol. 15, 57-62.
- Gustafsson, J. K., Ermund, A., Johansson, M. E. V., Schutte, A., Hansson, G. C., and Sjovall, H. (2012) An ex vivo method for studying mucus formation, properties and thickness in human colonic biopsies and mouse small and large intestinal explants. Am. J. Physiol. Gastrointest. Liver Physiol. 302. G430-G438.
- Johansson, M. E. V. and Hansson, G. C. (2011) Keeping Bacteria at a Distance. Science 334, 182-183.
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