Welcome to the 2018 Homepage of the
MUCIN BIOLOGY GROUPS
(MUCINBIOLOGISKA GRUPPERNA)
THIS IS THE COMMON HOMEPAGE OF THE MUCIN BIOLOGY GROUPS
GUNNAR C. HANSSON GROUP
MALIN E.V. JOHANSSON GROUP
THAHER PELASEYED GROUP
KAW - Knut and Alice Wallenberg Center, click to the right
Lederhausen's Center for Cystic Fibrosis Research, click to the right
at the
University of Gothenburg, Gothenburg, Sweden
 
NEWS JANUARY 2018:
Paper in CELL Host&Microbe; Schroeder,B.O., Birchenough,G.M.H., Ståhlman, M., Arike, L., Johansson, M.E.V., Hansson G. C. and Bäckhed, F. (2017) Bifidobacterium or fiber protect against diet-induced deterioration of the inner colonic mucus layer. CELL Host & Microbe on-line Dec 23
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Paper in J. Clinical Oncology (IMPACT 24) Jabbar, Karolina S., Arike, Liisa, Verbeke, Caroline S., Sadik, Riadh, and Hansson, Gunnar C. (2017) Highly Accurate Identification of Cystic Precursor Lesions of Pancreatic Cancer Through Targeted Mass Spectrometry: A Phase IIc Diagnostic Study. J.Clin.Oncology on-line Nov 11, 2017.
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Paper in BBRC Ermund, A., Meiss, L. N., Rodriguez-Pineiro, A. M., Bähr, A., Nilsson, H. E., Trillo-Muyo, S., Ridley, C., Thornton, D. J., Wine, J. J., Hebert, H., Klymiuk, N., and Hansson, G. C. (2017) The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin. Biochem. Biophys. Res. Commun. 492, 331-337.
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Full article in SCIENCE; George Birchenough, Elisabeth Nyström, Malin E.V: Johansson and Gunnar C. Hansson (2016) A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. SCIENCE 352: 1535 - 1542.
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Malin E.V. Johansson and Gunnar C. Hansson REVIEW in NATURE Immunology August 2016
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ALL GRANTS for the Mucin Biology Groups the coming 3-4 years >24 MSEK/year (>3 Million USD/year) include grants from K.-A. Wallenberg Foundation (2018-2023), National Institute of Health (NIH) (2016-2021), European Research Council (ERC) (2016-2021), Vetenskapsrådet (Swedish Research Council) 2018-2022), Cancerfonden (2018-2020), ALF 2018-2020), North American Cystic Fibrosis Fooundation (2017-2018), Lederhausens Foundation for CF research, Hjärt-lung fonden, Svenska sällskapet Medicinsk Forskning, Wennergrensstiftelsen. In addition we have three post-docs in US financed by Vetenskapsrådet (2) and EU (Marie Curie).
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December 2017: Thaher Pelaseyed: 4-year research position from Svenska Sällskapet Medicinsk Forskning and money for post-doc positions from Wennergren Stiftelsen.
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December 2017: Anna Ermund: 1-year research position from Svenska Riksförbundet Cystisk Fibros.
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June 2016: Malin E.V. Johansson appointed as Senior Lecturer
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March 31, 2016: Gunnar C. Hansson installed as member 1678 at the Swedish Royal Academy of Sciences (KVA)
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A New Mucin Sequence Database 2.0 was opened September 5, 2015
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Mucins in Health and Disease Conference, Robinson College, Cambridge, UK
The 'Cambridge' meeting will be held next time July 27 - August 2 2019. For further details contact conference secretary Gursharn Hutchins: gursharn.hutchins@kcl.ac.uk
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SEE and LISTEN to us at:
  • Svensk Gastroenterologisk Förening (SGF) forskarskola. January 11-13, 2017 (MEVJ)
  • Univ. of Alabama at Birmingham, Cystic Fibrosis Center, Feb. 10, 2017 (GCH)
  • Gordon Conference Cilia, Mucus and Mucociliary Interactions, Galvestone, TX Feb. 12-17, 2017 (George, Birchenough, GCH, Anna Ermund)
  • Canadian Digestive Disease Week, Fairmont Banff Springs, Banff, Alberta, Canada, March 3-6, 2017 (MEVJ)
  • Novel Concepts in Innate Immunity 2017, Tubingen, Germany March 27-29, 2017 (GCH)
  • European Cystic Fibrosis Basic Conference, march 29 - April 1, 2017 (GCH)Faro, Protugal (GCH)
  • Digestive Disease Week - AGA. Chicago May 6-9. (Pleanry talk GCH. Posters/talks MEVJ, GB, JB, SvdP, JG, KSJ, CR)
  • European Cystic Fibrosis COnference Seville, Italy, June 7-10 (GCH)
  • Mucosal Immunology, Washington DC, July 19-22, 2017 (GCH)
  • Mucin in Health and Disease, Cambridge, UK, July 24-28, 2017 (most of the group)
  • 6th International Conference on Anarobic Parasites Newcastle upon Tyne, UK, Aug. 31-Sept 3 30, 2017 (GCH)
  • Novo Nordisk Fond Prize Confernce, Gothenburg September 6, 2017 (GCH)
  • UK Cystic Fibrosis Conference, Nottingham, UK, Sept. 6-7, 2017 (Anna Ermund)
  • IBD Nordic Conference, Stockholm Oct. 5-6, 2017 (GCH)
  • UEG Week, Barcelona, Oct. 28 - Nov. 1, 2017 (MEVJ)
  • North American Cystic Fibrosis Conference, Indianapolis, IN, Nov. 2-4, 2017 (Anna Ermund)
  • North Atlantic Respiratory Conference, Lousanne, Switzerland , Jan. 17-19, 2018 (GCH)
  • Nevrogastroenterologimöte, Oslo, Mar. 14, 2018 (MEVJ)
  • Alfred Benzon Foundation Sympoisum on Glycotherapeutics, Copenhagen August 27-30, 2018 (GCH)


RECENT PUBLICATIONS (2015-2017)
  • Jabbar, Karolina S., Arike, Liisa, Verbeke, Caroline S., Sadik, Riadh, and Hansson, Gunnar C. (2017) Highly Accurate Identification of Cystic Precursor Lesions of Pancreatic Cancer Through Targeted Mass Spectrometry: A Phase IIc Diagnostic Study. J.Clin.Oncology on-line. 11-22-. IMPACT 15
  • Wichert, Rielana, Ermund, Anna, Schmidt, Stefanie, Schweinlin, Matthias, Ksiazek, Miroslaw, Arnold, Philipp, Knittler, Katharina, Wilkens, Frederike, Potempa, Barbara, Rabe, Bj+Ârn, Stirnberg, Marit, Lucius, Ralph, Bartsch, J+Ârg W., Nikolaus, Susanna, Falk-Paulsen, Maren, Rosenstiel, Philip, Metzger, Marco, Rose-John, Stefan, Potempa, Jan, Hansson, Gunnar C., Dempsey, Peter J., and Becker-Pauly, Christoph. (2017) Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Reports 21, 2090-2103.
  • Schroeder, B. O., Birchenough, G. M.H., Ståhlman, M., Arike, L., Johansson, M. E.V., Hansson, G. C. and Bäckhed, F. (2017) Bifidobacterium and fiber protect against diet-induced deterioration of the inner colonic mucus layer. CELL Host & Microbe, in press
  • Wine, J. J., Hansson, G. C., Konig, P., Joo, N. S., Ermund, A., and Pieper, M. (2017) Progress in understanding mucus abnormalities in cystic fibrosis airways. J.Cystic Fibrosis on-line.
  • Ermund, A., Meiss, L. N., Rodriguez-Pineiro, A. M., Bähr, A., Nilsson, H. E., Trillo-Muyo, S., Ridley, C., Thornton, D. J., Wine, J. J., Hebert, H., Klymiuk, N., and Hansson, G. C. (2017) The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin. Biochem. Biophys. Res. Commun. 492, 331-337.
  • Birchenough, G.M.H. and Hansson, G.C. (2017) Bacteria Tell Us How to Protect Our Intestine. CELL Host & Microbe 22, 3-4.
  • Ermund, A., Recktenwald, C. V., Skjak-Braek, G., Meiss, L. N., Onsoyen, E., Rye, P. D., Dessen, A., Myrset, A. H., and Hansson, G. C. (2017) OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating calcium. Clin. Exp. Pharmacol. Physiol., 44, 639-647.
  • Birchenough, G.M.H., Dalgakiran, F., Witcomb, L. A., Johansson, M. E. V., McCarthy, A. J., Hansson, G. C. and. Taylor, P. W. Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection. Sci. Rep. 7, 83
  • Bosmans, J. W. A. M., Jongen, A. C. H. M., Birchenough, G. M. H., Nystr+Âm, E. E. L., Gijbels, M. J. J., Derikx, J. P. M., Bouvy, N. D., and Hansson, G. C. (2017) Functional mucous layer and healing of proximal colonic anastomoses in an experimental model. Brit. J. Surgery , 104, 619-630.
  • Arike, L., Holmén-Larsson, J., and Hansson G.C. (2017) Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases. Glycobiology, 27, 318-328
  • Bergström, J. H., Birchenough, G. M. H., Katona, G., Schroeder, B. O., Schutte, A., Ermund, A., Johansson, M. E. V., and Hansson G. C. (2016) Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc. Natl. Acad. Sci. USA 113, 13833-13838.
  • Birchenough, G. M. H., Nystrom, E. L. N., Johansson, M. E. V., and Hansson G. C. (2016) A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science 352, 1535-1542.
  • Johansson, M. E. V. and Hansson, G. C. (2016) Immunological aspects of intestinal mucus and mucins. Nature Rev.Immunol. 16, 639-649
  • Johansson, M. E. V. and Hansson, G. C. (2016) The Mucins. Encyclopedia Immunobiology 2, 381-388.
  • Recktenwald, C. V. and Hansson, G. C. (2016) The reduction-insensitive bonds of the MUC2 mucin are isopeptide bonds. J.Biol.Chem. 249, 13580-13590.
  • Arike, L. and Hansson, G.C. (2016) The Densely O-glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal Bacteria. J. Mol. Biol. 428, 3221-3229.
  • Earle, K. A., Billings, G., Sigal, M., Lichtman, J. S., Hansson, G. C., Elias, J. E., Amieva, M. R., Huang, K. C., and Sonnenburg, J. L. (2015) Quantitative Imaging of Gut Microbiota Spatial Organization. Cell Host Microbe 18, 478–488, 478–488.
  • Johansson, M. E. V., Jacobsson, H. E., Holmén-Larsson, J., Schütte, A., Ermund, A., Rodriguez-Pineiro, A., Arike, L., Wising, C., Svensson, F., Bäckhed, F., and Hansson G. C. (2015) Normalization of the host intestinal mucus systems requires long-term colonization. Cell Host Microbe 18: 582-592.
  • Ermund, A., Meiss, L. N. Gustafsson, J. K., and Hansson, G. C. (2015) Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus. Eur J Pharmacol. 764: 109-117.
  • Wenzel, U. A., Jonstrand, C., Hansson, G. C., and Wick, M. J. (2015) CD103+CD11b+ dendritic cells induce TH17 T cells in Muc2-deficient mice with extensively spread colitis. PLoS ONE 10: e0130750.
  • A. Wang, J. Li, Y. Zhao, M. E. Johansson, H. Xu, and F. K. Ghishan. (2015) Loss of NHE8 expression impairs intestinal mucosal integrity. Am J Physiol Gastrointest.Liver Physiol. on-line
  • Ana M. Rodriguez-Pineiro and Malin E. V. Johansson (2015) The colonic mucus protection depends on the microbiota. Gut Microbes: 6, 326-330
  • Nancy A. Erickson, Elisabeth E. L. Nystrom, Lars Mundhenk, Liisa Arike, Rainer Glauben, Markus M. Heimesaat, Andre Fischer, Stefan Bereswill, George M. H. Birchenough, Achim D. Gruber, and Malin E. V. Johansson (2015) The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice. PLoS ONE 10 (7):e0131991.
  • Hickey, C. A., Kuhn, K. A., Donermeyer, D. L., Porter, N. T., Jin, C., Cameron, E. A., Jung, H., Kaiko, G. E., Wegorzewska, M., Malvin, N. P., Glowacki, R. W., Hansson, G. C., Allen, P. M., Martens, E. C., and Stappenbeck T. S. (2015) Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles. Cell Host Microbe. 17, 672-680.
  • Birchenough, G. M. H., Johansson, M. E. V., Gustafsson, J.K., Bergstrom, J.H., and Hansson, G. C. (2015) New developments in goblet cell mucus secretion and function. Mucosal Immunol. on-line
  • Jakobsson, H. E., Rodriguez-Pineiro, A. M., Schütte, A., Ermund, A., Boysen, P., Sommer, F., Bäckhed, F., Hansson, G. C., and Johansson M. E. V. (2015) The gut microbiota composition impairs the colon inner mucus layer barrier. EMBO Reports 16, 164-177.
  • Hannan, T.J., Roberts, P.J., Riehl, T.E., van der Post, S., Binkley, J. M., Schwartz, D.J., Miyoshi, H., Mack, M., Schwendener, R.A., Hooton, T.M., Stappenbeck, T.S., Hansson, G.C., Stenson, W.F., Colonna, M., Stapleton, A.E. and Hultgren, S.J. (2014) Inhibition of cyclooxygenase-2 prevents chronic and recurrent bladder infection. EBioMedicine, 2014.10.011
  • van der Post, S., Thomsson, K.A., and Hansson, G. C. (2014) A multiple enzyme approach for the characterization of glycan modifications on the C-Terminus of the intestinal MUC2 mucin. J. Proteome Res., 13, 6013-6023.
  • Ermund, A., Meiss, L., Scholte, B. J., and Hansson G. C. (2015) Hypertonic saline releases the attached small intestinal cystic fibrosis mucus. Clin. Exp. Pharm. Physiol. 42, 69-75.