Welcome to the 2014 Homepage of the
MBC - Mucus, Bacteria and Colitis SSF Center, click to the right
KAW - Knut and Alice Wallenberg Center, click to the right
Lederhausen's Center for Cystic Fibrosis Research, click to the right
at the
University of Gothenburg, Gothenburg, Sweden
NEWS MARCH 2014: Is the intestinal goblet cell a major immune cell? See CELL Host&Microbe March issue, 15: 251-
The Mucin Biology Groups are seeking new members with skills in protein biochemistry, mass spectrometry and proteases. After our discoveries around the formation and properties of the intestinal mucus layers, we have a leading role in the understanding of the protection of the intestine. The post-doc will have direct access to our Q-exactive and Orbitrap mass spectrometers for elucidating processing of the MUC2 mucin and related proteins including their cleavage sites and nature of proteases responsible for cleavages. We are working as a large team on this largely unexplored area that has become central for understanding intestinal commensal bacteria, inflammatory bowel diseases (ulcerative colitis) and cystic fibrosis.
Contact gunnar.hansson@medkem.gu.se OR malin.johansson@medkem.gu.se
Welcome to out teams! Gunnar and Malin
Publication in JNCI; Journal of National Cancer Institute: Proteomic diagnosis for pancreatic cysts (see below)
SEE and LISTEN to us at:
  • Arthritis, infections and autoimmunity, Ustron, Poland. March 4-8, 2014 (GCH)
  • 109th Interantional Titisee Conference – Microbiome-host mutualism in the shaping of host immunity, Titisee, Germany. April 9-13, 2014 (GCH)
  • Annual Meeting of the KNVM & NVMM, the Dutch microbiology and medical microbiology societies, NL. April 16, 2014 (MJ)
  • Internatinal Probiotics Association Conference, Athens, Greece. May 9-11, 2014 (GCH)
  • Department lecture Eberhard-Karls-Universität Tübingen, DE. June 3-4, 2014. (MJ)
  • 37th European Cystic Fibrosis Conference, Plenary Lecture, Gothenburg, Sweden. June 11-14, 2014 (GCH)
  • GLYCO-T 2014, Porto, Portugal. June 18-21, 2014 (GCH)
  • British Society of Gastroenterology Annual Meeting, Manchester, UK. June 19, 2014 (MJ)
  • Federation of European Physiological Societies FEPS 2014, Budapest, Hungary, August 27-30, 2014 (GCH)
  • National Institute of Health-NIDDK. Consensus meeting: Host-Microbiota Interactions: How Host Physiology and Disease Pathophysiology Are Affected by the Gut Microbiota. Current state-of-the-art and future directions for research. Bethesda September 9-10 2014 (GCH)
  • European Mucosal Immunology Group meeting, Glasgow, UK. October 9-12, 2014 (GCH)
  • Gordon Conference: Cilia, Mucus & Mucociliary Interactions. Galveston, TX. February 8-14 2015 (GCH)
  • Keystone Symposia: Gut microbiota modulation of host physiology – Search for mechanisms. Keystone, CO. March 1-6 2015 (GCH)

  • Jabbar, K. S., Verbeke, C., Hyltander, A. G., Sjovall, H., Hansson, G. C., and Sadik, R. (2014) Proteomic Mucin Profiling for the Identification of Cystic Precursors of Pancreatic Cancer. J.Natl.Cancer Inst. 106, djt439. IMPACT 14.3
  • Johansson, M.E.V. and Hansson, G.C. (2014) Is the intestinal goblet cell a major immune cell? CELL H&M, 15, 251-
  • Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., and Hansson, G. C. (2014) Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and in patients with ulcerative colitis. Gut 63, 281-291.
  • Xiao, F., Yu, Q., Li, J., Johansson, M. E., Singh, A. K., Xia, W., Riederer, B., Engelhardt, R., Montrose, M., Soleimani, M., Tian, D. A., Xu, G., Hansson, G. C., and Seidler, U. (2014) Slc26a3 deficiency is associated with loss of colonic HCO secretion, absence of a firm mucus layer, and barrier impairment in mice. Acta Physiol (Oxf), on -line,
  • Sommer, F., Adam, N., Johansson, M. E. V., Xia, L., Hansson, G. C., and Bäckhed, F. (2014) Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture. PLoS ONE 9, e85254