Welcome to the 2019 Homepage of the
MUCIN BIOLOGY GROUPS
(MUCINBIOLOGISKA GRUPPERNA)
THIS IS THE COMMON HOMEPAGE OF THE MUCIN BIOLOGY GROUPS
GUNNAR C. HANSSON GROUP
MALIN E.V. JOHANSSON GROUP
THAHER PELASEYED GROUP
GEORGE BIRCHENOUGH GROUP
KAW - Knut and Alice Wallenberg Center, click to the right
Lederhausen's Center for Cystic Fibrosis Research, click to the right
 
NEWS APRIL 2019:
Karolina S. Jabbar, BROAD-Wallenberg Post-doc position for going to Ramnik Xavier at BROAD and Harvard, Boston, MA
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Welcome back from US Jenny Gustafsson and Sjoerd van der Post, now with their own funding.
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Paper in CELL Host&Microbe; Schroeder,B.O., Birchenough,G.M.H., Ståhlman, M., Arike, L., Johansson, M.E.V., Hansson G. C. and Bäckhed, F. (2018) Bifidobacterium or fiber protect against diet-induced deterioration of the inner colonic mucus layer. CELL Host & Microbe 23, 27-40
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Paper in in J. Clin. Invest. InSights Fernández-Blanco, J. A., Fakih, D., Arike, L., Rodríguez-Pineiro, A., Martinez-Abad, B., Skansebo, E., Jackson, S., Root, J., Singh, D., McCrae, C., Evans, C. M., Astrand, A., Ermund, A., and Hansson, Gunnar C. (2018) Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs. J.Clin.Invest.Insights 3, e120994.
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Paper in Ermund, A., Meiss, L. N., Dolan, Brendan, Bahr, A., Klymiuk, N., and Hansson, G. C. (2018) The mucin bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation. Eur.Resp.J. 52(2), 1800457.
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Full article in SCIENCE; George Birchenough, Elisabeth Nyström, Malin E.V: Johansson and Gunnar C. Hansson (2016) A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. SCIENCE 352: 1535 - 1542.
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ALL GRANTS for the Mucin Biology Groups the 2019 >35 MSEK/year include grants from K.-A. Wallenberg Foundation (2018-2023), National Institute of Health (NIH) (2016-2021), European Research Council (ERC) (2016-2021), Vetenskapsrådet (Swedish Research Council) 2018-2022), Cancerfonden (2018-2020), ALF 2018-2020), Gates Foundation (2019-2021), Lederhausens Foundation for CF research, Hjärt-lung fonden, Svenska sällskapet Medicinsk Forskning, Wennergrensstiftelsen. In addition we have one post-doc in US financed by EU (Marie Curie).
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December 2018: George Birchenough 4-year Starting Grant from Vetenskapsrådet.
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A An updated Mucin Sequence Database 2.1 was opened March 20, 2019 with the complete MUC2 and MUC6 sequences
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Mucins in Health and Disease Conference, Robinson College, Cambridge, UK
The 'Cambridge' meeting will be held next time July 27 - August 2 2019. For further details see homepage: https://www.mucinconference.com/
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SEE and LISTEN to us at:
  • Gordon Conference Mucus, Cilia, and Mucociliary Inteactions, Lucca (Barga), Italy , Feb. 17-22, 2019 (GCH)
  • European Cystic Fibrosis Society Basic Science Conference, Dubrovnik, Croatia. Mar. 27-30, 2019 (GCH)
  • Lokalföreningen Syd Riksförbundet Cystisk Fibros: årsmöte, Lund. Mar 30, 2019 (AE)
  • Harvard Digestive Disease Center Spring Scientific Meeting, Boston, MA, USA, April 2, 2019 (GCH)
  • KOL på framkanten, Sahlgrenska Universitetssjukhuset, May 7, 2019 (GCH)
  • Cystic Fibrosis Nordic Masterclass, May 9, 2019 (GCH)
  • North American Cystic Fibrosis Research Conference, Stove, VM, USA. June 23-26, 2019 (GCH)
  • UEG Basic Science Course 2019 - Importance of ion channels for mucus properties, Pecs, Hungary. July 4-6, 2019 (AE)
  • Mucus in Health and Disease 'Cambridge Meeting' (see www.mucinconference.com ), July 27- Aug. 2, 2019 (TP, GCH, MEVJ, et al.)
  • Eukaryome, impact on intestinal homeostasis and mucsoal immunology, Institut Pasteur, Paris, France. Oct. 16-18, 2019 (MEVJ)
  • Nature and Nature Medicine: The NextGene Immunoloy, Feb. 2-5, 2020 (GCH)


RECENT PUBLICATIONS (2016-2019)
  • van der Post, S, Jabbar, K. S., Birchenough, G., Arike, L., Akhtar, N., Sjövall, H., Johansson, M. E. V., and Hansson, G.C. (2019) Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis. Gut, in press
  • Perspective Birchenough, G., Schroeder, B. O., Bäckhed, F., and Hansson, G. C. (2018) Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier. Gut Microbes on-line.
  • Svensson, F., Lang, T., Johansson, M. E. V., and Hansson, G. C. (2018) The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals. Scientific Reports 8, 17503.
  • Review Ermund, A., Trillo-Muyo, S., and Hansson, G. C. (2018) Assembly, Release, and Transport of Airway Mucins in Pigs and Humans. Ann. Am. Thorac. Soc. 15, S159-S163.
  • Fernández-Blanco, J. A., Fakih, D., Arike, L., Rodríguez-Pineiro, A., Martinez-Abad, B., Skansebo, E., Jackson, S., Root, J., Singh, D., McCrae, C., Evans, C. M., Astrand, A., Ermund, A., and Hansson, G. C. (2018) Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs. J. Clin. Invest.Insights 3, e120994.
  • Ermund, A., Meiss, L. N., Dolan, B., Bahr, A., Klymiuk, N., and Hansson, G. C. (2018) The mucin bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation. Eur. Resp. J. 52(2), 1800457.
  • Nystrom, E. E. L., Birchenough, G. M. H., van der Post, S., Arike, L., Gruber, A. D., Hansson, G. C., and Johansson, M. E. V. (2018) Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity. EBioMed 33, 134-143. >li>Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bahr A, Klymiuk N, Wine JJ, Koeck PJ, Thornton DJ, Hebert H, Hansson GC (2018) Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers.. J. Biol. Chem. 293, 5746-5754.
  • Jabbar, Karolina S., Arike, Liisa, Verbeke, Caroline S., Sadik, Riadh, and Hansson, Gunnar C. (2017) Highly Accurate Identification of Cystic Precursor Lesions of Pancreatic Cancer Through Targeted Mass Spectrometry: A Phase IIc Diagnostic Study. J.Clin.Oncology on-line. 11-22-. IMPACT 15
  • Wichert, Rielana, Ermund, Anna, Schmidt, Stefanie, Schweinlin, Matthias, Ksiazek, Miroslaw, Arnold, Philipp, Knittler, Katharina, Wilkens, Frederike, Potempa, Barbara, Rabe, Bj+Ârn, Stirnberg, Marit, Lucius, Ralph, Bartsch, J+Ârg W., Nikolaus, Susanna, Falk-Paulsen, Maren, Rosenstiel, Philip, Metzger, Marco, Rose-John, Stefan, Potempa, Jan, Hansson, Gunnar C., Dempsey, Peter J., and Becker-Pauly, Christoph. (2017) Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Reports 21, 2090-2103.
  • Schroeder, B. O., Birchenough, G. M.H., Ståhlman, M., Arike, L., Johansson, M. E.V., Hansson, G. C. and Bäckhed, F. (2017) Bifidobacterium and fiber protect against diet-induced deterioration of the inner colonic mucus layer. CELL Host & Microbe, in press
  • Wine, J. J., Hansson, G. C., Konig, P., Joo, N. S., Ermund, A., and Pieper, M. (2017) Progress in understanding mucus abnormalities in cystic fibrosis airways. J.Cystic Fibrosis on-line.
  • Ermund, A., Meiss, L. N., Rodriguez-Pineiro, A. M., Bähr, A., Nilsson, H. E., Trillo-Muyo, S., Ridley, C., Thornton, D. J., Wine, J. J., Hebert, H., Klymiuk, N., and Hansson, G. C. (2017) The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin. Biochem. Biophys. Res. Commun. 492, 331-337.
  • Birchenough, G.M.H. and Hansson, G.C. (2017) Bacteria Tell Us How to Protect Our Intestine. CELL Host & Microbe 22, 3-4.
  • Ermund, A., Recktenwald, C. V., Skjak-Braek, G., Meiss, L. N., Onsoyen, E., Rye, P. D., Dessen, A., Myrset, A. H., and Hansson, G. C. (2017) OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating calcium. Clin. Exp. Pharmacol. Physiol., 44, 639-647.
  • Birchenough, G.M.H., Dalgakiran, F., Witcomb, L. A., Johansson, M. E. V., McCarthy, A. J., Hansson, G. C. and. Taylor, P. W. Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection. Sci. Rep. 7, 83
  • Bosmans, J. W. A. M., Jongen, A. C. H. M., Birchenough, G. M. H., Nyström, E. E. L., Gijbels, M. J. J., Derikx, J. P. M., Bouvy, N. D., and Hansson, G. C. (2017) Functional mucous layer and healing of proximal colonic anastomoses in an experimental model. Brit. J. Surgery , 104, 619-630.
  • Arike, L., Holmén-Larsson, J., and Hansson G.C. (2017) Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases. Glycobiology, 27, 318-328
  • Bergström, J. H., Birchenough, G. M. H., Katona, G., Schroeder, B. O., Schutte, A., Ermund, A., Johansson, M. E. V., and Hansson G. C. (2016) Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc. Natl. Acad. Sci. USA 113, 13833-13838.
  • Birchenough, G. M. H., Nystrom, E. L. N., Johansson, M. E. V., and Hansson G. C. (2016) A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science 352, 1535-1542.
  • Johansson, M. E. V. and Hansson, G. C. (2016) Immunological aspects of intestinal mucus and mucins. Nature Rev.Immunol. 16, 639-649
  • Johansson, M. E. V. and Hansson, G. C. (2016) The Mucins. Encyclopedia Immunobiology 2, 381-388.
  • Recktenwald, C. V. and Hansson, G. C. (2016) The reduction-insensitive bonds of the MUC2 mucin are isopeptide bonds. J.Biol.Chem. 249, 13580-13590.
  • Arike, L. and Hansson, G.C. (2016) The Densely O-glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal Bacteria. J. Mol. Biol. 428, 3221-3229.