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| Welcome to the 2012 Homepage of the |
MUCIN BIOLOGY GROUP
(MUCINBIOLOGISKA GRUPPEN) |
| MBC - Mucus, Bacteria and Colitis SSF Center |
| Lederhausen's Center for Cystic Fibrosis Research |
| at the |
| University of Gothenburg, Gothenburg, Sweden |
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| NEWS APRIL 2012 |
| PUBLICATION IN PROC. NATL. ACAD. SCI. USA |
Calcium and pH-dependent Packing and Release of the Gel-forming MUC2 Mucin |
Daniel Ambort, Malin E. V. Johansson, Jenny K. Gustafsson, Harriet E. Nilsson, Anna Ermund, Bengt R. Johansson, Philip Köck, Hans Hebert, and Gunnar C. Hansson |
OPEN ACCESS: http://www.pnas.org.ezproxy.ub.gu.se/content/early/2012/03/21/1120269109.abstract |
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Cystic Fibrosis Foundation USA GRANT |
| USD 40,000 per year |
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Knut and Alice Wallenberg Foundation GRANT awarded to P.I. Gunnar C. Hansson |
| 28,000,000 SEK for for five years |
'The mucus layer formed by the MUC2 mucin as the habitat of the colon commensal microbiota'
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| SEE and LISTEN to us at: |
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| RECENT PUBLICATIONS |
- Ambort, D., Johansson, M. E. V., Gustafsson, J. K., Nilsson, H., Ermund, A., Johansson, B. R., Kock, P., Hebert, H., and Hansson, G. C. (2012) Calcium and pH-dependent Packing and Release of the Gel-forming MUC2 Mucin. Proc.Natl.Acad.Sci.U.S.A. on-line
- Rodriguez-Pineiro, A.M., van der Post, S., Johansson, M.E.V., Thomsson, K.A., Nesvizhskii, A.I., and Hansson, G.C. (2012) Proteomic study of the mucin granulae in an intestinal goblet cell model. J. Proteome Res. on line
- Johansson, M.E.V., Hansson, G.C. (2012) Preservation of Mucus in Histological Sections, Immunostaining of Mucins in Fixed Tissue, and Localization of Bacteria with FISH. Methods Mol. Biol. 842, 229-235
- Gustafsson, J.K., Sjövall, H., Hansson, G.C. (2012) Ex vivo measurements of mucus secretion by colon explants. Methods Mol. Biol. 842, 237-243
- Johansson, M.E.V., Hansson, G.C. (2012) Analysis of assembly of secreted mucins. Methods Mol. Biol. 842, 109-121
- R Hansson, G.C. (2012) Role of mucus layers in gut infection and inflammation. Curr. Opinion Microbiol. 15, 57-62.
- Gustafsson, J. K., Ermund, A., Johansson, M. E. V., Schutte, A., Hansson, G. C., and Sjovall, H. (2012) An ex vivo method for studying mucus formation, properties and thickness in human colonic biopsies and mouse small and large intestinal explants. Am. J. Physiol. Gastrointest. Liver Physiol. 302. G430-G438.
- Johansson, M. E. V. and Hansson, G. C. (2011) Keeping Bacteria at a Distance. Science 334, 182-183.
- Johansson, M.E.V., Ambort, D., Pelaseyed, T., Schütte, A., Gustafsson, J.K.,
Ermund, A., Subramani, D.B., Holmen-Larsson, J.M., Thomsson, K.A., Bergstrom, J.H.,
Sjoerd van der Post, S., Rodriguez-Pineiro, A.M., Sjövall, H., Bäckström, M.,
Hansson, G.C. (2011) Composition and functional role of the mucus layers in the intestine.
Cell. Mol. Life Sci., 68, 3635-3641.
- Pelaseyed, T. and Hansson, G. C. CFTR anion channel modulates expression of human transmembrane
mucin MUC3 via the PDZ protein GOPC. J. Cell Sci. 2011 124: 3074-3083
- Songhet, P., Barthel, M., Stecher, B., Müller, A.J., Kremer, M., Hansson, G.C., Hardt W.D. (2011)
Stromal IFN-?R-Signaling Modulates Goblet Cell Function During Salmonella Typhimurium Infection.
PLoS One. 2011;6(7):e22459.
- Fu J, Wei B, Wen T, Johansson ME, Liu X, Bradford E, Thomsson KA, McGee S,
Mansour L, Tong M, McDaniel JM, Sferra TJ, Turner JR, Chen H, Hansson GC, Braun
J, Xia L.
Loss of intestinal core 1-derived O-glycans causes spontaneous colitis
in mice.
J Clin Invest. 2011 Apr 1;121(4):1657-66. doi: 10.1172/JCI45538. Epub
2011 Mar 7. PubMed PMID: 21383503; PubMed Central PMCID: PMC3069788.
- Thomsson E, Persson L, Grahn A, Snäll J, Ekblad M, Brunhage E, Svensson F,
Jern C, Hansson GC, Bäckström M, Bergström T.
Recombinant glycoprotein E produced
in mammalian cells in large-scale as an antigen for varicella-zoster-virus
serology.
J Virol Methods. 2011 Apr 22. [Epub ahead of print] PubMed PMID:
21540058.
- Ambort D, van der Post S, Johansson ME, Mackenzie J, Thomsson E, Krengel U,
Hansson GC.
Function of the CysD domain of the gel-forming MUC2 mucin.
Biochem J.
2011 May 15;436(1):61-70. PubMed PMID: 21338337.
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