Welcome to the 2016 Homepage of the
MUCIN BIOLOGY GROUPS
(MUCINBIOLOGISKA GRUPPERNA)
THIS IS THE COMMON HOMEPAGE OF THE TWO MUCIN BIOLOGY GROUPS
GUNNAR C. HANSSON GROUP
MALIN E.V. JOHANSSON GROUP
KAW - Knut and Alice Wallenberg Center, click to the right
Lederhausen's Center for Cystic Fibrosis Research, click to the right
at the
University of Gothenburg, Gothenburg, Sweden
 
NEWS DECEMBER 2016:
Full article in PNAS; Bergström, J. H., Birchenough, G. M. H., Katona, G., Schroeder, B. O., Schutte, A., Ermund, A., Johansson, M. E. V., and Hansson G. C. (2016) Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc. Natl. Acad. Sci. USA on-line
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Full article in SCIENCE; George Birchenough, Elisabeth Nyström, Malin E.V: Johansson and Gunnar C. Hansson: A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. SCIENCE 352: 1535 - 1542. CLICK empty line below for FULL TEXT.
Full Text
See also news flash: Full Text
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Malin E.V. Johansson and Gunnar C. Hansson REVIEW in NATURE Immunology August 2016
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June: Gunnar C. Hansson and Malin E.V. Johansson recieves Grant from National Institute of Health (NIH) for the years 2016-2021
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August: Gunnar C. Hansson recieves Advanced Grant from European Research Council ERC for the years 2016-2021
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June 2016: Malin E.V. Johansson appointed as Senior Lecturer
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March 31, 2016: Gunnar C. Hansson installed as member 1678 at the Swedish Royal Academy of Sciences (KVA)
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A New Mucin Sequence Database 2.0 was opened September 5, 2015
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Mucins in Health and Disease Conference, Robinson College, Cambridge, UK
The 'Cambridge' meeting will be held next time July 24-27 2017. For further details contact conference secretary Gursharn Hutchins: gursharn.hutchins@kcl.ac.uk
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SEE and LISTEN to us at:
  • Nordic Glycobiology Meeting, Copenhagen, Dec. 9-10, 2016 (Joakim Bergström, Liisa Arike, Aaran Lewis, Hannah Schneider, Brenda Dolan)
  • Svensk Gastroenterologisk Förening (SGF) forskarskola. January 11-13, 2017 (MEVJ)
  • Univ. of Alabama at Birmingham, Cystic Fibrosis Center, Feb. 10, 2017 (GCH)
  • Gordon Conference Cilia, Mucus and Mucociliary Interactions, Galvestone, TX Feb. 12-17, 2017 (George, Birchenough, GCH, Anna Ermund)
  • Canadian Digestive Disease Week, Fairmont Banff Springs, Banff, Alberta, Canada, March 3-6, 2017 (MEVJ)
  • Novel Concepts in Innate Immunity 2017, Tubingen, Germany March 27-29, 2017 (GCH)
  • European Cystic Fibrosis Basic Conference, march 29 - April 1, 2017 (GCH)Faro, Protugal (GCH)
  • Digestive Disease Week - AGA. Chicago May 6-9. (Pleanry talk GCH. Posters/talks MEVJ, GB, JB, SvdP, JG, KSJ, CR)
  • European Cystic Fibrosis COnference Seville, Italy, June 7-10 (GCH)
  • Mucosal Immunology, Washington DC, July 19-22 (GCH)
  • Mucin in Health and Disease, July 24-28, 2017 (most of teh group)
  • FASEB SRC meeting. Steamboat Springs CO July 30 - Aug. 8 (GCH)
  • 6th International Conference on Anarobic Parasites Newcastle upon Tyne, UK, Aug 31-Sept 3 30, 2017 (GCH)


RECENT PUBLICATIONS (2015-2016)
  • Bergström, J. H., Birchenough, G. M. H., Katona, G., Schroeder, B. O., Schutte, A., Ermund, A., Johansson, M. E. V., and Hansson G. C. (2016) Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc. Natl. Acad. Sci. USA on-line
  • Birchenough, G. M. H., Nystrom, E. L. N., Johansson, M. E. V., and Hansson G. C. (2016) A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science 352, 1535-1542.
  • Johansson, M. E. V. and Hansson, G. C. (2016) Immunological aspects of intestinal mucus and mucins. Nature Rev.Immunol. 16, 639-649
  • Johansson, M. E. V. and Hansson, G. C. (2016) The Mucins. Encyclopedia Immunobiology 2, 381-388.
  • Recktenwald, C. V. and Hansson, G. C. (2016) The reduction-insensitive bonds of the MUC2 mucin are isopeptide bonds. J.Biol.Chem. 249, 13580-13590.
  • Arike, L. and Hansson, G.C. (2016) The Densely O-glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal Bacteria. J. Mol. Biol. On-line.
  • Earle, K. A., Billings, G., Sigal, M., Lichtman, J. S., Hansson, G. C., Elias, J. E., Amieva, M. R., Huang, K. C., and Sonnenburg, J. L. (2015) Quantitative Imaging of Gut Microbiota Spatial Organization. Cell Host Microbe 18, 478–488, 478–488.
  • Johansson, M. E. V., Jacobsson, H. E., Holmén-Larsson, J., Schütte, A., Ermund, A., Rodriguez-Pineiro, A., Arike, L., Wising, C., Svensson, F., Bäckhed, F., and Hansson G. C. (2015) Normalization of the host intestinal mucus systems requires long-term colonization. Cell Host Microbe 18: 582-592.
  • Ermund, A., Meiss, L. N. Gustafsson, J. K., and Hansson, G. C. (2015) Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus. Eur J Pharmacol. 764: 109-117.
  • Wenzel, U. A., Jonstrand, C., Hansson, G. C., and Wick, M. J. (2015) CD103+CD11b+ dendritic cells induce TH17 T cells in Muc2-deficient mice with extensively spread colitis. PLoS ONE 10: e0130750.
  • A. Wang, J. Li, Y. Zhao, M. E. Johansson, H. Xu, and F. K. Ghishan. (2015) Loss of NHE8 expression impairs intestinal mucosal integrity. Am J Physiol Gastrointest.Liver Physiol. on-line
  • Ana M. Rodriguez-Pineiro and Malin E. V. Johansson (2015) The colonic mucus protection depends on the microbiota. Gut Microbes: 6, 326-330
  • Nancy A. Erickson, Elisabeth E. L. Nystrom, Lars Mundhenk, Liisa Arike, Rainer Glauben, Markus M. Heimesaat, Andre Fischer, Stefan Bereswill, George M. H. Birchenough, Achim D. Gruber, and Malin E. V. Johansson (2015) The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice. PLoS ONE 10 (7):e0131991.
  • Hickey, C. A., Kuhn, K. A., Donermeyer, D. L., Porter, N. T., Jin, C., Cameron, E. A., Jung, H., Kaiko, G. E., Wegorzewska, M., Malvin, N. P., Glowacki, R. W., Hansson, G. C., Allen, P. M., Martens, E. C., and Stappenbeck T. S. (2015) Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles. Cell Host Microbe. 17, 672-680.
  • Birchenough, G. M. H., Johansson, M. E. V., Gustafsson, J.K., Bergstrom, J.H., and Hansson, G. C. (2015) New developments in goblet cell mucus secretion and function. Mucosal Immunol. on-line
  • Jakobsson, H. E., Rodriguez-Pineiro, A. M., Schütte, A., Ermund, A., Boysen, P., Sommer, F., Bäckhed, F., Hansson, G. C., and Johansson M. E. V. (2015) The gut microbiota composition impairs the colon inner mucus layer barrier. EMBO Reports 16, 164-177.
  • Hannan, T.J., Roberts, P.J., Riehl, T.E., van der Post, S., Binkley, J. M., Schwartz, D.J., Miyoshi, H., Mack, M., Schwendener, R.A., Hooton, T.M., Stappenbeck, T.S., Hansson, G.C., Stenson, W.F., Colonna, M., Stapleton, A.E. and Hultgren, S.J. (2014) Inhibition of cyclooxygenase-2 prevents chronic and recurrent bladder infection. EBioMedicine, 2014.10.011
  • van der Post, S., Thomsson, K.A., and Hansson, G. C. (2014) A multiple enzyme approach for the characterization of glycan modifications on the C-Terminus of the intestinal MUC2 mucin. J. Proteome Res., 13, 6013-6023.
  • Ermund, A., Meiss, L., Scholte, B. J., and Hansson G. C. (2015) Hypertonic saline releases the attached small intestinal cystic fibrosis mucus. Clin. Exp. Pharm. Physiol. 42, 69-75.