Welcome to the 2021 Homepage of the
MUCIN BIOLOGY GROUPS
(MUCINBIOLOGISKA GRUPPERNA)
THIS IS THE COMMON HOMEPAGE OF THE MUCIN BIOLOGY GROUPS
GUNNAR C. HANSSON GROUP
MALIN E.V. JOHANSSON GROUP
THAHER PELASEYED GROUP
GEORGE BIRCHENOUGH GROUP
SJOERD VAN DER POST GROUP
JENNY GUSTAFSSON GROUP
KAW - Knut and Alice Wallenberg Center, click to the right
Lederhausen's Center for Cystic Fibrosis Research, click to the right.
See also novel presentation (in Swedish) of mucus and CF at the Lederhausen homepage
 
NEWS FEBRUARY 2021:
Gunnar C. Hansson is awarded The Royal Swedish King Medal 8th size with Serafimer ordens ribbon for his meritorious achievements in medical research
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The Laboratories has moved to new premises at Lundberg Laboratories on Medicinaregatan 9C, 4th floor. See MAP in Contact and Map to the left.
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Sjerd van der Post has got the 4-year Starting Grant from the Swedish Research Coucil (Vetenskapsradet)and will establish his own group as PI.
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Jenny Gustafsson has recieved teh 4-year Starting Grant from the Swedish Research Coucil (Vetenskapsradet) with a position at the Department of Physiology. She will establish her own group as PI, affiliated to the Mucin Biology Groups.
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Paper in GUT; Jabbar, K. S., Dolan, B., Eklund, L., Wising, C., Ermund, A., Johansson, A., Tornblom, H., Simren, M., and Hansson, G. C. (2020) Association between Brachyspira and irritable bowel syndrome with diarrhoea.
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Paper in CELL REPORTS; Arike, Liisa, Seiman, Andrus, van der Post, Sjoerd, Rodriguez Pineiro, Ana M., Ermund, Anna, Schutte, Andre, Bäckhed, Fredrik, Johansson, Malin E. V., and Hansson, Gunnar C. Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota. Cell Reports 30(4), 1077-1087.
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Review in J. Cell Science; Pelaseyed, Thaher and Hansson, Gunnar C. (2020) Membrane mucins of the intestine at a glance. Journal of Cell Science 133(5), jcs240929.
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Paper in J. Biol. Chem.; Schroeder, B. O., Birchenough, G. M. H., Pradhan, M., Nystrom, E. E. L., Henricsson, M., Hansson, G. C., and Backhed, F. (2020) Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice. J. Biol. Chem. 296, 15712-15726.
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ALL GRANTS for the Mucin Biology Groups the 2020 >35 MSEK/year include grants from K.-A. Wallenberg Foundation (2018-2023), National Institute of Health (NIH) (2016-2021), NIH (2020-2024), European Research Council (ERC) (2016-2021), Vetenskapsrådet (Swedish Research Council) 2018-2022), Cancerfonden (2018-2020), ALF 2018-2021), Gates Foundation (2019-2021), Lederhausens Foundation for CF research, Hjärt-lung fonden (2020-2023, AE), Svenska sällskapet Medicinsk Forskning (TP), Wennergrensstiftelsen.
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An updated Mucin Sequence Database 2.1 was opened March 20, 2019 with the complete MUC2 and MUC6 sequences
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Mucins in Health and Disease Conference, Robinson College, Cambridge, UK
The 'Cambridge' meeting will be held next time 2022 and organized by Malin EV Johansson and Chris Evans.
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SEE and LISTEN to us at:
  • Due to the ongoing Corona pandemi, there are no on-site presentations planned for the moment
  • Nature and Nature Medicine: The NextGene Immunoloy, Feb. 2-5, 2020 (GCH)


RECENT PUBLICATIONS (2019-2020)
  • 286. Schroeder, B. O., Birchenough, G. M. H., Pradhan, M., Nystrom, E. E. L., Henricsson, M., Hansson, G. C., and Backhed, F. (2020) Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice. J. Biol. Chem. 296, 15712-15726.
  • 285. REV: Hansson, G. C. (2020) Mucins and the Microbiome. Annual Rev. Biochem. 89, 769-793.
  • 284. Arike, L., Hansson, G. C., and Recktenwald, C. V. (2020) Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps. Anal. Biochem. 597, 113668.
  • 283. Fakih, D., Rodriguez Pineiro, A. M., Trillo-Muyo, S., Evans, C. M., Ermund, A., and Hansson, G. C. (2020) Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin. Am. J. Physiol. Lung Cell Mol. Physiol, 318, L1270-L1279.
  • 282. Jabbar, K. S., Dolan, B., Eklund, L., Wising, C., Ermund, A., Johansson, A., Tornblom, H., Simren, M., and Hansson, G. C. (2020) Association between Brachyspira and irritable bowel syndrome with diarrhoea. Gut, on-line.
  • Pelaseyed, Thaher and Hansson, Gunnar C. (2020) Membrane mucins of the intestine at a glance. Journal of Cell Science 133(5), jcs240929.
  • Arike, Liisa, Seiman, Andrus, van der Post, Sjoerd, Rodriguez Pineiro, Ana M., Ermund, Anna, Schutte, Andre, Backhed, Fredrik, Johansson, Malin E. V., and Hansson, Gunnar C. Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota. Cell Reports 30(4), 1077-1087.
  • Nystrom, E. E. L., Arike, L., Ehrencrona, E., Hansson, G. C., and Johansson, M. E. V. CLCA1 forms non-covalent oligomers in colonic mucus and has MUC2-processing properties. J. Biol. Chem., 294, 17075-17089, 2019
  • Volk, J.K., Abad, B.M., Nystrom, E. E. L., Svensson, F., Javerfelt, S., Hansson, G.C., Johansson, M. E. V., Birchenough, G. M. H. (2019) Inflammasome activity is not required for inner mucus layer formation or function in the distal colon. J. Exp. Med., 216, 2602-2618.
  • Schneider, H., Berger, E., Dolan, B., Martinez-Abad, B., Arike, L., Pelaseyed, T., and Hansson, G. C. (2019) The human transmembrane mucin MUC17 responds to TNF? by increased presentation at the plasma membrane. Biochem. J., 476, 2281-2295.
  • Blacher, Eran, Bashiardes, Stavros, Shapiro, Hagit, Rothschild, Daphna, Mor, Uria, Dori-Bachash, Mally, Kleimeyer, Christian, Moresi, Claudia, Harnik, Yotam, Zur, Maya, Zabari, Michal, Brik, Rotem Ben-Zeev, Kviatcovsky, Denise, Zmora, Niv, Cohen, Yotam, Bar, Noam, Levi, Izhak, Amar, Nira, Mehlman, Tevie, Brandis, Alexander, Biton, Inbal, Kuperman, Yael, Tsoory, Michael, Alfahel, Leenor, Harmelin, Alon, Schwartz, Michal, Israelson, Adrian, Arike, Liisa, Johansson, Malin E. V., Hansson, Gunnar C., Gotkine, Marc, Segal, Eran, and Elinav, Eran. (2019) Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature 572, 474-480.
  • Vega, G., Guequen, A., Johansson, M. E. V., Arike, L., Martinez-Abad, B., Nystrom, E. E. L., Scudieri, P., Pedemonte, N., Millar-Buchner, P., Philp, A. R., Galietta, L. J., Hansson, G. C., and Flores, C. A. (2019) Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium. Frontiers in Physiology 10, 694.
  • Furter, M., Sellin, M. E., Hansson, G. C., and Hardt, W. D. (2019) Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract. Cell Reports 27(9), 2665-2678.
  • REV: Hansson, G. C. (2019) Mucus and mucins in diseases of the intestinal and respiratory tracts. J. Internal Medicine 285, 479-490.
  • van der Post, S, Jabbar, K. S., Birchenough, G., Arike, L., Akhtar, N., Sjövall, H., Johansson, M. E. V., and Hansson, G.C. (2019) Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis. Gut, 68, 2142-2151