Welcome to the 2015 Homepage of the
MBC - Mucus, Bacteria and Colitis SSF Center, click to the right
KAW - Knut and Alice Wallenberg Center, click to the right
Lederhausen's Center for Cystic Fibrosis Research, click to the right
at the
University of Gothenburg, Gothenburg, Sweden
Gunnar C. Hansson elected member of the Swedish Royal Academy of Sciences
JUST OUT!! CELL Host&Microbe, November issue(2015)18: 582-592. Normalization of the host intestinal mucus systems requires long-term colonization.
EMBO Reports 2015: The composition of the gut microbiota shapes the colon mucus barrier
Eur J Pharmacol. (2015) 764:109-117: Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus
PLoS ONE (2015) 10:e0131991: The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice
A New Mucin Sequence Database 2.0 was opened September 5, 2015
New developments in goblet cell mucus secretion and function
Goblet cells and their main secretory product, mucus, have long been poorly appreciated; however, recent discoveries have changed this and placed these cells at the center stage of our understanding of mucosal biology and the immunology of the intestinal tract. The mucus system differs substantially between the small and large intestine, although it is built around MUC2 mucin polymers in both cases. Furthermore, that goblet cells and the regulation of their secretion also differ between these two parts of the intestine is of fundamental importance for a better understanding of mucosal immunology. There are several types of goblet cell that can be delineated based on their location and function. The surface colonic goblet cells secrete continuously to maintain the inner mucus layer, whereas goblet cells of the colonic and small intestinal crypts secrete upon stimulation, for example, after endocytosis or in response to acetyl choline. However, despite much progress in recent years, our understanding of goblet cell function and regulation is still in its infancy.
Mucins in Health and Disease Conference, Robinson College, Cambridge, UK
The 'Cambridge' meeting will be held next time July 24-27 2017. For further details contact conference secretary Gursharn Hutchins: gursharn.hutchins@kcl.ac.uk
SEE and LISTEN to us at:
  • Gordon Conference: Cilia, Mucus & Mucociliary Interactions. Galveston, TX. February 8-14 2015 (GCH)
  • Gordon Conference: Saliva, Galveston, TX. February 15-20 2015 (GCH)
  • Keystone Symposia: Gut microbiota modulation of host physiology – Search for mechanisms. Keystone, CO. March 1-6 2015 (GCH)
  • 2015 Cystic Fibrosis Foundation Research Conference: Pushing the Frontiers. May 31 – June 2, 2015, Chantilly, Virginia (GCH)
  • 38th European Cystic Fibrosis Conference, 10 - 13 June 2015, Brussels, Belgium (GCH)
  • 4th International Symposium of the German Center for Lung Research (DZL), Heidelberg, Germany, June 25 to 27, 2015 (GCH)
  • Mucins in Health and Disease Conference July 18th – 22nd 2015 Robinson College, Cambridge, UK (the whole group)
  • 2015 North American Cystic Fibrosis Conference October 8-10, 2015, Phoenix Convention Center in Phoenix, Arizona (GCH)
  • MAYO Foundatoin Scottsdale, October 9, 2015, Arizona (GCH)
  • Novartis, Boston, October 14, 2015,(GCH)
  • Cystic Fibrosis: Contribution of animal models. Tours, France, November 26-27, 2015 (GCH)
  • BugClub, Microbiology, Standord University, November 30, 2015 (GCH)
  • Glycobiology Meeting, Decemebr 1-4, 2015, San Francisco, CA (GCH)

  • Earle, K. A., Billings, G., Sigal, M., Lichtman, J. S., Hansson, G. C., Elias, J. E., Amieva, M. R., Huang, K. C., and Sonnenburg, J. L. (2015) Quantitative Imaging of Gut Microbiota Spatial Organization. Cell Host Microbe 18, 478–488, 478–488.
  • Johansson, M. E. V., Jacobsson, H. E., Holmén-Larsson, J., Schütte, A., Ermund, A., Rodriguez-Pineiro, A., Arike, L., Wising, C., Svensson, F., Bäckhed, F., and Hansson G. C. (2015) Normalization of the host intestinal mucus systems requires long-term colonization. Cell Host Microbe 18: 582-592.
  • Ermund, A., Meiss, L. N. Gustafsson, J. K., and Hansson, G. C. (2015) Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus. Eur J Pharmacol. 764: 109-117.
  • Wenzel, U. A., Jonstrand, C., Hansson, G. C., and Wick, M. J. (2015) CD103+CD11b+ dendritic cells induce TH17 T cells in Muc2-deficient mice with extensively spread colitis. PLoS ONE 10: e0130750.
  • A. Wang, J. Li, Y. Zhao, M. E. Johansson, H. Xu, and F. K. Ghishan. (2015) Loss of NHE8 expression impairs intestinal mucosal integrity. Am J Physiol Gastrointest.Liver Physiol. on-line
  • Ana M. Rodriguez-Pineiro and Malin E. V. Johansson (2015) The colonic mucus protection depends on the microbiota. Gut Microbes: 6, 326-330
  • Nancy A. Erickson, Elisabeth E. L. Nystrom, Lars Mundhenk, Liisa Arike, Rainer Glauben, Markus M. Heimesaat, Andre Fischer, Stefan Bereswill, George M. H. Birchenough, Achim D. Gruber, and Malin E. V. Johansson (2015) The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice. PLoS ONE 10 (7):e0131991.
  • Hickey, C. A., Kuhn, K. A., Donermeyer, D. L., Porter, N. T., Jin, C., Cameron, E. A., Jung, H., Kaiko, G. E., Wegorzewska, M., Malvin, N. P., Glowacki, R. W., Hansson, G. C., Allen, P. M., Martens, E. C., and Stappenbeck T. S. (2015) Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles. Cell Host Microbe. 17, 672-680.
  • Birchenough, G. M. H., Johansson, M. E. V., Gustafsson, J.K., Bergstrom, J.H., and Hansson, G. C. (2015) New developments in goblet cell mucus secretion and function. Mucosal Immunol. on-line
  • Jakobsson, H. E., Rodriguez-Pineiro, A. M., Schütte, A., Ermund, A., Boysen, P., Sommer, F., Bäckhed, F., Hansson, G. C., and Johansson M. E. V. (2015) The gut microbiota composition impairs the colon inner mucus layer barrier. EMBO Reports 16, 164-177.
  • Hannan, T.J., Roberts, P.J., Riehl, T.E., van der Post, S., Binkley, J. M., Schwartz, D.J., Miyoshi, H., Mack, M., Schwendener, R.A., Hooton, T.M., Stappenbeck, T.S., Hansson, G.C., Stenson, W.F., Colonna, M., Stapleton, A.E. and Hultgren, S.J. (2014) Inhibition of cyclooxygenase-2 prevents chronic and recurrent bladder infection. EBioMedicine, 2014.10.011
  • van der Post, S., Thomsson, K.A., and Hansson, G. C. (2014) A multiple enzyme approach for the characterization of glycan modifications on the C-Terminus of the intestinal MUC2 mucin. J. Proteome Res., 13, 6013-6023.
  • Ermund, A., Meiss, L., Scholte, B. J., and Hansson G. C. (2015) Hypertonic saline releases the attached small intestinal cystic fibrosis mucus. Clin. Exp. Pharm. Physiol. 42, 69-75.
  • Gustafsson, J. K., Linden, S. K., Alwan, A. H., Scholte, B. J., Hansson, G. C., and Sjovall, H. (2015) Carbachol-induced colonic mucus formation requires transport via NKCC1, K channels and CFTR. Pflugers Arch., DOI 10.1007/s00424-014-1595-y.
  • Johansson, M. E. V. (2014) Mucus Layers in Inflammatory Bowel Disease. Inflamm.Bowel.Dis.
  • Sadio, A. Gustafsson, J. K, Pereira, B., Gomes, C.P., Hansson, G. C., David, L., Pego, A. P., and Almeida, R. (2014) Modified-Chitosan/siRNA Nanoparticles Downregulate Cellular CDX2 Expression and Cross the Gastric Mucus Barrier. PLoS ONE 9 (6):e99449, 2014.
  • Berström, J. H., Berg, K. A., Rodriguez-Pineiro, A. M., Stecher, B., Johansson, M. E. V., and Hansson, G. C. (2014) AGR2, nn endoplasmic reticulum protein is secreted into the gastrointestinal mucus. PLoS ONE 9 (8):e104186.
  • van der Post, S. and Hansson, G.C. (2014). Membrane protein profiling of human colon reveals distinct regional differences. Mol.Cell.Proteomics on-line.
  • Schütte, A., Ermund, A., Becker-Pauly, C., Johansson, M.E.V., Rodriguez-Pineiro, A. M., Bäckhed, Müller, F.S., Lottaz, D., Bond, J.S., and Hansson, G.C. (2014) Microbial Induced Meprin ß Cleavage in MUC2 Mucin and Functional CFTR Channel are Required to Release Anchored Small Intestinal Mucus. Proc.Natl.Acad.Sci.USA in press
  • Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A. van der Post, S, Svensson, F., Rodríguez-Piñeiro, A. M., Nyström, E. E.L., Wising, C., Johansson, M. E.V., and Hansson, G. C. (2014) The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol. Rev., 260, 8-20.
  • Wenzel, U.A., Magnusson, M. K., Rydström, A., Jonstrand, C., Hengst, J., Johansson, M.E.V., Velcich, A., Öhman, L., Strid, H., Sjövall, H., Hansson, G.C., and Wick, M.J. (2014) Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis. PLoS ONE, 9, e100217.
  • Nilsson, H. E., Ambort, D., Backstrom, M., Thomsson, E., Koeck, P. J., Hansson, G. C., and Hebert, H. (2014) Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly. J.Mol.Biol. 426, 2567-2579
  • Jabbar, K. S., Verbeke, C., Hyltander, A. G., Sjovall, H., Hansson, G. C., and Sadik, R. (2014) Proteomic Mucin Profiling for the Identification of Cystic Precursors of Pancreatic Cancer. J.Natl.Cancer Inst. 106, djt439. IMPACT 14.3
  • Johansson, M.E.V. and Hansson, G.C. (2014) Is the intestinal goblet cell a major immune cell? CELL H&M, 15, 251-
  • Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., and Hansson, G. C. (2014) Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and in patients with ulcerative colitis. Gut 63, 281-291.
  • Xiao, F., Yu, Q., Li, J., Johansson, M. E., Singh, A. K., Xia, W., Riederer, B., Engelhardt, R., Montrose, M., Soleimani, M., Tian, D. A., Xu, G., Hansson, G. C., and Seidler, U. (2014) Slc26a3 deficiency is associated with loss of colonic HCO secretion, absence of a firm mucus layer, and barrier impairment in mice. Acta Physiol (Oxf), on -line,
  • Sommer, F., Adam, N., Johansson, M. E. V., Xia, L., Hansson, G. C., and Bäckhed, F. (2014) Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture. PLoS ONE 9, e85254