Welcome to the 2014 Homepage of the
MUCIN BIOLOGY GROUPS
(MUCINBIOLOGISKA GRUPPERNA)
THIS IS THE COMMON HOMEPAGE OF THE TWO MUCIN BIOLOGY GROUPS
GUNNAR C. HANSSON GROUP
MALIN E.V. JOHANSSON GROUP
MBC - Mucus, Bacteria and Colitis SSF Center, click to the right
KAW - Knut and Alice Wallenberg Center, click to the right
Lederhausen's Center for Cystic Fibrosis Research, click to the right
at the
University of Gothenburg, Gothenburg, Sweden
 
NEWS SEPTEMBER 2014:
PUBLICATION IN PROC. NATL. ACAD. SCI USA
We have now shown that the gel-forming mucins are secreted , but still attached to the goblet cells. In the small intestine the protease Meprin beta is required to release and make the mucus as it is normally non-attached. This process is controlled by bacteia and does not work in Cystic Fibrosis as the mucin is not propery unfolded.
http://www.pnas.org.ezproxy.ub.gu.se/content/early/2014/08/07/1407597111.abstract
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REVIEW Malin E. Johansson. Mucus Layers in Inflammatory Bowel Disease. Inflamm.Bowel.Dis., 2014.
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REVIEW Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A. van der Post, S, Svensson, F., Rodríguez-Piñeiro, A. M., Nyström, E. E.L., Wising, C., Johansson, M. E.V., and Hansson, G. C. (2014) The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol. Rev., 260, 8-20.
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van der Post, S. and Hansson, G.C. (2014). Membrane protein profiling of human colon reveals distinct regional differences. Mol.Cell.Proteomics on-line
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Publication in JNCI; Journal of National Cancer Institute: Proteomic diagnosis for pancreatic cysts (see below)
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SEE and LISTEN to us at:
  • Federation of European Physiological Societies FEPS 2014, Budapest, Hungary, August 27-30, 2014 (GCH)
  • National Institute of Health-NIDDK. Consensus meeting: Host-Microbiota Interactions: How Host Physiology and Disease Pathophysiology Are Affected by the Gut Microbiota. Current state-of-the-art and future directions for research. Bethesda September 9-10 2014 (GCH)
  • 26th meeting of European Intestinal Transport Group (EITG) Marstrand 2-5 October 2014
  • European Mucosal Immunology Group meeting, Glasgow, UK. October 9-12, 2014 (GCH)
  • Microbes, Metabolism and Mucosal Cicuits: Harvard Medical School, Boston
  • 2015
  • Gordon Conference: Cilia, Mucus & Mucociliary Interactions. Galveston, TX. February 8-14 2015 (GCH)
  • Gordon COnference: Saliva, Galveston, TX. February 15-20 2015 (GCH)
  • Keystone Symposia: Gut microbiota modulation of host physiology – Search for mechanisms. Keystone, CO. March 1-6 2015 (GCH)


RECENT PUBLICATIONS (2014)
  • Johansson, M. E. V. (2014) Mucus Layers in Inflammatory Bowel Disease. Inflamm.Bowel.Dis.
  • Sadio, A. Gustafsson, J. K, Pereira, B., Gomes, C.P., Hansson, G. C., David, L., Pego, A. P., and Almeida, R. (2014) Modified-Chitosan/siRNA Nanoparticles Downregulate Cellular CDX2 Expression and Cross the Gastric Mucus Barrier. PLoS ONE 9 (6):e99449, 2014.
  • Berström, J. H., Berg, K. A., Rodriguez-Pineiro, A. M., Stecher, B., Johansson, M. E. V., and Hansson, G. C. (2014) AGR2, nn endoplasmic reticulum protein is secreted into the gastrointestinal mucus. PLoS ONE 9 (8):e104186.
  • van der Post, S. and Hansson, G.C. (2014). Membrane protein profiling of human colon reveals distinct regional differences. Mol.Cell.Proteomics on-line.
  • Schütte, A., Ermund, A., Becker-Pauly, C., Johansson, M.E.V., Rodriguez-Pineiro, A. M., Bäckhed, Müller, F.S., Lottaz, D., Bond, J.S., and Hansson, G.C. (2014) Microbial Induced Meprin ß Cleavage in MUC2 Mucin and Functional CFTR Channel are Required to Release Anchored Small Intestinal Mucus. Proc.Natl.Acad.Sci.USA in press
  • Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A. van der Post, S, Svensson, F., Rodríguez-Piñeiro, A. M., Nyström, E. E.L., Wising, C., Johansson, M. E.V., and Hansson, G. C. (2014) The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol. Rev., 260, 8-20.
  • Wenzel, U.A., Magnusson, M. K., Rydström, A., Jonstrand, C., Hengst, J., Johansson, M.E.V., Velcich, A., Öhman, L., Strid, H., Sjövall, H., Hansson, G.C., and Wick, M.J. (2014) Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis. PLoS ONE, 9, e100217.
  • Nilsson, H. E., Ambort, D., Backstrom, M., Thomsson, E., Koeck, P. J., Hansson, G. C., and Hebert, H. (2014) Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly. J.Mol.Biol. 426, 2567-2579
  • Jabbar, K. S., Verbeke, C., Hyltander, A. G., Sjovall, H., Hansson, G. C., and Sadik, R. (2014) Proteomic Mucin Profiling for the Identification of Cystic Precursors of Pancreatic Cancer. J.Natl.Cancer Inst. 106, djt439. IMPACT 14.3
  • Johansson, M.E.V. and Hansson, G.C. (2014) Is the intestinal goblet cell a major immune cell? CELL H&M, 15, 251-
  • Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., and Hansson, G. C. (2014) Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and in patients with ulcerative colitis. Gut 63, 281-291.
  • Xiao, F., Yu, Q., Li, J., Johansson, M. E., Singh, A. K., Xia, W., Riederer, B., Engelhardt, R., Montrose, M., Soleimani, M., Tian, D. A., Xu, G., Hansson, G. C., and Seidler, U. (2014) Slc26a3 deficiency is associated with loss of colonic HCO secretion, absence of a firm mucus layer, and barrier impairment in mice. Acta Physiol (Oxf), on -line,
  • Sommer, F., Adam, N., Johansson, M. E. V., Xia, L., Hansson, G. C., and Bäckhed, F. (2014) Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture. PLoS ONE 9, e85254