Welcome to the 2016 Homepage of the
KAW - Knut and Alice Wallenberg Center, click to the right
Lederhausen's Center for Cystic Fibrosis Research, click to the right
at the
University of Gothenburg, Gothenburg, Sweden
Full article in SCIENCE; George Birchenough, Elisabeth Nyström, Malin E.V: Johansson and Gunnar C. Hansson: A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. SCIENCE 352: 1535 - 1542. CLICK empty line below for FULL TEXT.
Full Text
See also news flash: Full Text
Malin E.V. Johansson and Gunnar C. Hansson REVIEW in NATURE Immunology August 2016
June: Gunnar C. Hansson and Malin E.V. Johansson recieves Grant from National Institute of Health (NIH) for the years 2016-2021
August: Gunnar C. Hansson recieves Advanced Grant from European Research Council ERC for the years 2016-2021
June 2016: Malin E.V. Johansson appointed as Senior Lecturer
March 31, 2016: Gunnar C. Hansson installed as member 1678 at the Swedish Royal Academy of Sciences (KVA)
A New Mucin Sequence Database 2.0 was opened September 5, 2015
Mucins in Health and Disease Conference, Robinson College, Cambridge, UK
The 'Cambridge' meeting will be held next time July 24-27 2017. For further details contact conference secretary Gursharn Hutchins: gursharn.hutchins@kcl.ac.uk
SEE and LISTEN to us at:
  • Gordon Conference: Cilia, Mucus & Mucociliary Interactions. Galveston, TX. February 8-14 2015 (GCH)
  • Gordon Conference: Saliva, Galveston, TX. February 15-20 2015 (GCH)
  • Keystone Symposia: Gut microbiota modulation of host physiology – Search for mechanisms. Keystone, CO. March 1-6 2015 (GCH)
  • 2015 Cystic Fibrosis Foundation Research Conference: Pushing the Frontiers. May 31 – June 2, 2015, Chantilly, Virginia (GCH)
  • 38th European Cystic Fibrosis Conference, 10 - 13 June 2015, Brussels, Belgium (GCH)
  • 4th International Symposium of the German Center for Lung Research (DZL), Heidelberg, Germany, June 25 to 27, 2015 (GCH)
  • Mucins in Health and Disease Conference July 18th – 22nd 2015 Robinson College, Cambridge, UK (the whole group)
  • 2015 North American Cystic Fibrosis Conference October 8-10, 2015, Phoenix Convention Center in Phoenix, Arizona (GCH)
  • MAYO Foundatoin Scottsdale, October 9, 2015, Arizona (GCH)
  • Novartis, Boston, October 14, 2015,(GCH)
  • Cystic Fibrosis: Contribution of animal models. Tours, France, November 26-27, 2015 (GCH)
  • BugClub, Microbiology, Standord University, November 30, 2015 (GCH)
  • Glycobiology Meeting, Decemebr 1-4, 2015, San Francisco, CA (GCH)
  • European Cystic Fibrosis Basic Conference, Pisa, Italy, March 30-April 2, 2016 (Anna Ermund)
  • Host-microbe interactions in the gut – from model systems to human disease. Wenner-Gren Center, Stockholm, June 15-18, 2016 (GCH)
  • European Cystic Fibrosis Conference, Basel, Switzerland, June 8-11, 2016 (GCH)
  • European Respiratory Society Conference, London, September 3-6, 2016 (GCH)
  • Sympoisum: First line of defense; Protective Immunity at Barrier Surfaces, Paul Robeson Campus Center, Newark, NJ. Sept 13-14, 2016 (GCH)
  • EMIG2016, Copenhagen, Denmark, October 19-21, 2016 (MEVJ)
  • Genentech, San Francisco South, October 25, 2016 (GCH)
  • Canadian Digestive Disease Week, Fairmont Banff Springs, Banff, Alberta, Canada, March 3-6, 2017 (MEVJ)
  • 6th International Conference on Anarobic Parasites Newcastle upon Tyne, UK, Aug 31-Sept 3 30, 2017 (GCH)

  • Birchenough, G. M. H., Nystrom, E. L. N., Johansson, M. E. V., and Hansson G. C. (2016) A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science 352, 1535-1542.
  • Johansson, M. E. V. and Hansson, G. C. (2016) Immunological aspects of intestinal mucus and mucins. Nature Rev.Immunol. in press
  • Johansson, M. E. V. and Hansson, G. C. (2016) The Mucins. Encyclopedia Immunobiology 2, 381-388.
  • Recktenwald, C. V. and Hansson, G. C. (2016) The reduction-insensitive bonds of the MUC2 mucin are isopeptide bonds. J.Biol.Chem. 249, 13580-13590.
  • Arike, L. and Hansson, G.C. (2016) The Densely O-glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal Bacteria. J. Mol. Biol. On-line.
  • Earle, K. A., Billings, G., Sigal, M., Lichtman, J. S., Hansson, G. C., Elias, J. E., Amieva, M. R., Huang, K. C., and Sonnenburg, J. L. (2015) Quantitative Imaging of Gut Microbiota Spatial Organization. Cell Host Microbe 18, 478–488, 478–488.
  • Johansson, M. E. V., Jacobsson, H. E., Holmén-Larsson, J., Schütte, A., Ermund, A., Rodriguez-Pineiro, A., Arike, L., Wising, C., Svensson, F., Bäckhed, F., and Hansson G. C. (2015) Normalization of the host intestinal mucus systems requires long-term colonization. Cell Host Microbe 18: 582-592.
  • Ermund, A., Meiss, L. N. Gustafsson, J. K., and Hansson, G. C. (2015) Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus. Eur J Pharmacol. 764: 109-117.
  • Wenzel, U. A., Jonstrand, C., Hansson, G. C., and Wick, M. J. (2015) CD103+CD11b+ dendritic cells induce TH17 T cells in Muc2-deficient mice with extensively spread colitis. PLoS ONE 10: e0130750.
  • A. Wang, J. Li, Y. Zhao, M. E. Johansson, H. Xu, and F. K. Ghishan. (2015) Loss of NHE8 expression impairs intestinal mucosal integrity. Am J Physiol Gastrointest.Liver Physiol. on-line
  • Ana M. Rodriguez-Pineiro and Malin E. V. Johansson (2015) The colonic mucus protection depends on the microbiota. Gut Microbes: 6, 326-330
  • Nancy A. Erickson, Elisabeth E. L. Nystrom, Lars Mundhenk, Liisa Arike, Rainer Glauben, Markus M. Heimesaat, Andre Fischer, Stefan Bereswill, George M. H. Birchenough, Achim D. Gruber, and Malin E. V. Johansson (2015) The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice. PLoS ONE 10 (7):e0131991.
  • Hickey, C. A., Kuhn, K. A., Donermeyer, D. L., Porter, N. T., Jin, C., Cameron, E. A., Jung, H., Kaiko, G. E., Wegorzewska, M., Malvin, N. P., Glowacki, R. W., Hansson, G. C., Allen, P. M., Martens, E. C., and Stappenbeck T. S. (2015) Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles. Cell Host Microbe. 17, 672-680.
  • Birchenough, G. M. H., Johansson, M. E. V., Gustafsson, J.K., Bergstrom, J.H., and Hansson, G. C. (2015) New developments in goblet cell mucus secretion and function. Mucosal Immunol. on-line
  • Jakobsson, H. E., Rodriguez-Pineiro, A. M., Schütte, A., Ermund, A., Boysen, P., Sommer, F., Bäckhed, F., Hansson, G. C., and Johansson M. E. V. (2015) The gut microbiota composition impairs the colon inner mucus layer barrier. EMBO Reports 16, 164-177.
  • Hannan, T.J., Roberts, P.J., Riehl, T.E., van der Post, S., Binkley, J. M., Schwartz, D.J., Miyoshi, H., Mack, M., Schwendener, R.A., Hooton, T.M., Stappenbeck, T.S., Hansson, G.C., Stenson, W.F., Colonna, M., Stapleton, A.E. and Hultgren, S.J. (2014) Inhibition of cyclooxygenase-2 prevents chronic and recurrent bladder infection. EBioMedicine, 2014.10.011
  • van der Post, S., Thomsson, K.A., and Hansson, G. C. (2014) A multiple enzyme approach for the characterization of glycan modifications on the C-Terminus of the intestinal MUC2 mucin. J. Proteome Res., 13, 6013-6023.
  • Ermund, A., Meiss, L., Scholte, B. J., and Hansson G. C. (2015) Hypertonic saline releases the attached small intestinal cystic fibrosis mucus. Clin. Exp. Pharm. Physiol. 42, 69-75.