Selected publications from the Center related to cystic fibrosis

Ermund, A., Meiss, L. N., Dolan, B., Jaudas, F., Ewaldsson, L., Bahr, A., Klymiuk, N., and Hansson, G. C. (2021) Mucus threads from surface goblet cells clear particles from the airways. Respiratory Research 22(1), 303.
Ehrencrona, E., van der Post, S., Gallego, P., Recktenwald, C. V., Rodriguez-Pineiro, A. M., Garcia-Bonete, M. J., Trillo-Muyo, S., Backstrom, M., Hansson, G. C., and Johansson, M. E. V. (2021) The IgG Fc-binding protein FCGBP is secreted with all GDPH sequences cleaved, but maintained by inter-fragment disulfide bonds. J. Biol. Chem. 297, 100871.
Giorgetti, M., Klymiuk, N., Bahr, A., Hemmerling, M., Jinton, L., Tarran, R., Malmgren, A., Astrand, A., Hansson, G. C., and Ermund, A. (2021) New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger inhibition. European Journal of Pharmacology 904, 174123.
REV: Hansson, G. C. (2020) Mucins and the Microbiome. Annual Rev. Biochem. 89, 769-793.
Fakih, D., Rodriguez Pineiro, A. M., Trillo-Muyo, S., Evans, C. M., Ermund, A., and Hansson, G. C. (2020) Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin. Am. J. Physiol. Lung Cell Mol. Physiol, 318, L1270-L1279.
Nystrom, E. E. L., Arike, L., Ehrencrona, E., Hansson, G. C., and Johansson, M. E. V. CLCA1 forms non-covalent oligomers in colonic mucus and has MUC2-processing properties. J. Biol. Chem., 294, 17075-17089, 2019
Vega, G., Guequen, A., Johansson, M. E. V., Arike, L., Martinez-Abad, B., Nystrom, E. E. L., Scudieri, P., Pedemonte, N., Millar-Buchner, P., Philp, A. R., Galietta, L. J., Hansson, G. C., and Flores, C. A. (2019) Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium. Frontiers in Physiology 10, 694.
REV: Hansson, G. C. (2019) Mucus and mucins in diseases of the intestinal and respiratory tracts. J. Internal Medicine 285, 479-490.
R Ermund, A., Trillo-Muyo, S., and Hansson, G. C. (2018) Assembly, Release, and Transport of Airway Mucins in Pigs and Humans. Ann. Am. Thorac. Soc. 15, S159-S163.
Fernandez-Blanco, J. A., Fakih, D., Arike, L., Rodriguez-Pineiro, A., Martinez-Abad, B., Skansebo, E., Jackson, S., Root, J., Singh, D., McCrae, C., Evans, C. M., Astrand, A., Ermund, A., and Hansson, G. C. (2018) Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs. J. Clin. Invest.Insights 3, e120994.
Ermund, A., Meiss, L. N., Dolan, B., Bahr, A., Klymiuk, N., and Hansson, G. C. (2018) The mucin bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation. Eur. Resp. J. 52(2), 1800457.
Nystrom, E. E. L., Birchenough, G. M. H., van der Post, S., Arike, L., Gruber, A. D., Hansson, G. C., and Johansson, M. E. V. (2018) Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity. EBioMed 33, 134-143.
Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bahr A, Klymiuk N, Wine JJ, Koeck PJ, Thornton DJ, Hebert H, Hansson GC (2018) Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers.. J. Biol. Chem. 293, 5746-5754.
263. Wichert, Rielana, Ermund, Anna, Schmidt, Stefanie, Schweinlin, Matthias, Ksiazek, Miroslaw, Arnold, Philipp, Knittler, Katharina, Wilkens, Frederike, Potempa, Barbara, Rabe, Bjorn, Stirnberg, Marit, Lucius, Ralph, Bartsch, Jorg W., Nikolaus, Susanna, Falk-Paulsen, Maren, Rosenstiel, Philip, Metzger, Marco, Rose-John, Stefan, Potempa, Jan, Hansson, Gunnar C., Dempsey, Peter J., and Becker-Pauly, Christoph. (2017) Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Reports 21, 2090-2103.
Wine, J. J., Hansson, G. C., Konig, P., Joo, N. S., Ermund, A., and Pieper, M. (2017) Progress in understanding mucus abnormalities in cystic fibrosis airways. J.Cystic Fibrosis 17, S35-S39.
Ermund, A., Meiss, L. N., Rodriguez-Pineiro, A. M., Bähr, A., Nilsson, H. E., Trillo-Muyo, S., Ridley, C., Thornton, D. J., Wine, J. J., Hebert, H., Klymiuk, N., and Hansson, G. C. (2017) The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin. Biochem. Biophys. Res. Commun. 492, 331-337.
Ermund, A., Recktenwald, C. V., Skjak-Braek, G., Meiss, L. N., Onsoyen, E., Rye, P. D., Dessen, A., Myrset, A. H., and Hansson, G. C. (2017) OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating calcium. Clin. Exp. Pharmacol. Physiol., 44, 639-647.
Ermund, A., Meiss, L. N. Gustafsson, J. K., and Hansson, G. C. (2015) Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus. Eur J Pharmacol. 764: 109-117.
Ermund, A., Meiss, L., Scholte, B. J., and Hansson G. C. (2015) Hypertonic saline releases the attached small intestinal cystic fibrosis mucus. Clin. Exp. Pharm. Physiol. 42, 69-75.
Gustafsson, J. K., Linden, S. K., Alwan, A. H., Scholte, B. J., Hansson, G. C., and Sjovall, H. (2015) Carbachol-induced colonic mucus formation requires transport via NKCC1, K channels and CFTR. Pflugers Arch., DOI 10.1007/s00424-014-1595-y.
Schütte, A., Ermund, A., Becker-Pauly, C., Johansson, M.E.V., Rodriguez-Pineiro, A. M., Bäckhed, Müller, F.S., Lottaz, D., Bond, J.S., and Hansson, G.C. (2014) Microbial Induced Meprin ß Cleavage in MUC2 Mucin and Functional CFTR Channel are Required to Release Anchored Small Intestinal Mucus. Proc.Natl.Acad.Sci.USA 111, 12396-12401.
Pelaseyed, T., Gustafsson, J. K., Gustafsson, I. J., Ermund, A., and Hansson, G. C. (2013) Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes. Am. J. Physiol. Cell Physiol. 305, C457-C467.
Gustafsson, J.K., Ermund, A., Ambort, D., Johansson, M.E.V., Nilsson, H.E., Thorell, K., Hebert, H., Sjövall, H., and Hansson, G. C. (2012) Bicarbonate and functional CFTR channel are required for proper mucin secretion and link Cystic Fibrosis with its mucus phenotype. J. Exp. Med., 209, 1263-1272
Ambort, D., Johansson, M. E. V., Gustafsson, J. K., Nilsson, H., Ermund, A., Johansson, B. R., Kock, P., Hebert, H., and Hansson, G. C. (2012) Calcium and pH-dependent Packing and Release of the Gel-forming MUC2 Mucin. Proc.Natl.Acad.Sci.U.S.A. 109, 5645-5650
Gustafsson, J.K., Sjovall, H., Hansson, G.C. (2012) Ex vivo measurements of mucus secretion by colon explants. Methods Mol. Biol. 842, 237-243
Johansson, M.E.V., Hansson, G.C. (2012) Analysis of assembly of secreted mucins. Methods Mol. Biol. 842, 109-121
R Hansson, G.C. (2012) Role of mucus layers in gut infection and inflammation. Curr. Opinion Microbiol. 15, 57-62.
Gustafsson, J. K., Ermund, A., Johansson, M. E. V., Schutte, A., Hansson, G. C., and Sjovall, H. (2012) An ex vivo method for studying mucus formation, properties and thickness in human colonic biopsies and mouse small and large intestinal explants. Am. J. Physiol. Gastrointest. Liver Physiol. 302. G430-G438.
Johansson, M.E.V., Ambort, D., Pelaseyed, T., Schütte, A., Gustafsson, J.K., Ermund, A., Subramani, D.B., Holmen-Larsson, J.M., Thomsson, K.A., Bergstrom, J.H., Sjoerd van der Post, S., Rodriguez-Pineiro, A.M., Sjövall, H., Bäckström, M., Hansson, G.C. (2011) Composition and functional role of the mucus layers in the intestine. Cell. Mol. Life Sci., 68, 3635-3641.
Pelaseyed, T. and Hansson, G. C. CFTR anion channel modulates expression of human transmembrane mucin MUC3 via the PDZ protein GOPC. J. Cell Sci. 2011 124: 3074-3083
Ambort D, van der Post S, Johansson ME, Mackenzie J, Thomsson E, Krengel U, Hansson GC.
Function of the CysD domain of the gel-forming MUC2 mucin.
Biochem J. 2011 May 15;436(1):61-70. PubMed PMID: 21338337.