Compilations of Mucin sequences (organized by species)

Compilations of Mucin associated sequences (organized by protein)6

Human and Mouse Proteomics Mucin Database (compiled as one FASTA file)5,6

Supplementary information to Lang, T., Hansson, GC., Samuelsson T. Gel-forming mucins appeared early in metazoan evolution. Proc Natl Acad Sci U S A. 2007 104, 16209-16214

Phylogenetic trees with bootstrap values

PTS repeats

EST support

Alignment of CysD domains


Welcome to the Mucin Database

of The Mucin Biology Group

Here we provide databases of mucin genes, transcripts, protein sequences and functional domains. The databases are from published mucins and novel mucins found by bioinformatic mining of the available genomes. We hope that this site and its databases will be useful for you!

Please refer to this database in your publication when you have used information from this. Reference: http://www.medkem.gu.se/mucinbiology/databases/

Responsible for content in this database is:

Gunnar C. Hansson, professor, head The Mucin Biology Group (gunnar.hansson@medkem.gu.se)
Tore Samuelsson, professor in bioinformatics (tore.samuelsson@medkem.gu.se)
Malin Johansson, PhD, post-doc  (malin.johansson@medkem.gu.se)
Prashamsha Haridass, Bioinformatic student (prashamsha.haridass@medkem.gu.se)

REFERENCES:

1T. Lang, M. Alexandersson, G. C. Hansson, and T. Samuelsson (2004) Bioinformatic identification of polymerizing and transmembrane mucins in the puffer fish Fugu rubripes. Glycobiology 14:521-527

2T. Lang, M.E.V. Johansson, T. Samuelsson, and G. C. Hansson (2005) The human mucin database of the Mucin Biology Group, http://www.medkem.gu.se/mucinbiology/databases/index.html

3T. Lang, G. C. Hansson, and T. Samuelsson. An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins. BMC Genomics 7:197, 2006 (3 August 2006) http://www.biomedcentral.com/1471-2164/7/197/abstract (open access).

4Tiange Lang, Gunnar C. Hansson and Tore Samuelsson (2007) Gel-forming mucins appeared early in metazoan evolution. Proc. Natl. Acad. Sci. USA 104: 16209-16214

5Johansson, M. E. V., Phillipson, M., Petersson, J., Holm, L., Velcich, A., and Hansson, G. C. (2008) The inner of the two Muc2 mucin dependent mucus layers in colon is devoid of bacteria. Proceedings of the National Academy of Sciences of the USA 105, 15064-15069.

6Johansson, M. E. V., Thomsson, K. A., and Hansson, G. C. (2009) Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein. Journal of Proteome Research 8, 3549-3557.