Protein domain file:
SS
(Yellow background)
Signal sequence.
PTS (Light orange)
Mucin domain. Rich of Pro, Ser, and
Thr.
PTS (Red)
Mucin
domain repeats part.
PTS (Red, bold)
Mucin domain 1 typical repeat unit.
VWD (Lime)
von Willebrand factor type D
domain.
CysD/CysD¡¯ (Pink)
Cys-rich
domain inserted in or around PTS domains.
SEA (Blue)
Domain found in Sea urchin sperm
protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding
carbohydrate side chains.
CK (
Cys-knot domain. Comprises glycoprotein hormones and the
C-terminal domain of various extracellular proteins. It is believed to be
involved in disulfide-linked dimerisation.
TM
(Turquoise background)
Transmembrane
domain.
NIDO (Pale blue)
Nidogen-like
domain, an extracellular domain found in nidogen and hypothetical proteins of
unknown function.
AMOP (Lavender)
This
domain may have a role in cell adhesion. It is called the AMOP domain after
Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular
and contains a number of cysteines that probably form disulphide bridges.
VWC (Pink background)
von Willebrand factor type C domain.
EGF (Dark Yellow background)
There is no clear separation
between noise and signal. Laminin_EGF is very similar, but has 8
instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF
domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is
the main reason of discrepancy between swiss-prot domain start/end and Pfam).
The family is hard to model due to many similar but different sub-types of EGF
domains. Pfam certainly misses a number of EGF domains
Gray (-50%)
The part in splice variant which is different from main sequence.
Underline (only in chicken Muc2, 5ac, 6 and 13 now)
The
part supported by ESTs.
mRNA flat file:
Each paragraph is one exon.
DNA flat file:
Green background: PTS exon.
Gray background(-25%): Other exon.
Green letters: UTR.
Pink letters: SNP.