Protein domain file:
SS (Yellow background)
PTS (Light orange)
Mucin domain. Rich of Pro, Ser, and Thr.
Mucin domain repeats part.
PTS (Red, bold)
Mucin domain 1 typical repeat unit.
von Willebrand factor type D domain.
Cys-rich domain inserted in or around PTS domains.
Domain found in Sea urchin sperm protein, Enterokinase, Agrin (SEA). Proposed function of regulating or binding carbohydrate side chains.
Cys-knot domain. Comprises glycoprotein hormones and the C-terminal domain of various extracellular proteins. It is believed to be involved in disulfide-linked dimerisation.
TM (Turquoise background)
NIDO (Pale blue)
Nidogen-like domain, an extracellular domain found in nidogen and hypothetical proteins of unknown function.
This domain may have a role in cell adhesion. It is called the AMOP domain after Adhesion associated domain in MUC4 and Other Proteins. This domain is extracellular and contains a number of cysteines that probably form disulphide bridges.
VWC (Pink background)
von Willebrand factor type C domain.
EGF (Dark Yellow background)
There is no clear separation between noise and signal. Laminin_EGF is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains
The part in splice variant which is different from main sequence.
mRNA flat file:
Each paragraph is one exon.
Plum letter: PTS exon.
DNA flat file:
Green background: PTS exon.
Gray background(-25%): Other exon.
Green letters: UTR.
Pink letters: SNP.