BIBLIOGRAPHY

 

2022

 

 

 

 

Gunnar C. Hansson

 

 

 

 

REV            = Review

PERSP        = Perspective

B                 = Book Chapter

L                 = Letter


 

BIBLIOGRAPHY

 

Gunnar C. Hansson

 

PUBLISHED

 

300. PERSP. Hansson, G. C. (2022) A Golgi oxygen 3 sensor controls intestinal mucin glycosylation. EMBO J., e2484.

 

299. *Hoang, O. N., *Ermund, A., Jaramillo, A. M., Fakih, D., French, C. B., Flores, J. R., Karmouty-Quintana, H., Magnusson, J. M., Fois, G., Fauler, M., Frick, M., Braubach, P., Hales, J. B., Kurten, R. C., Panettieri, R., Vergara, L., Ehre, C., Adachi, R., Tuvim, M. J., *Hansson, G. C., and *Dickey, B. F. Mucins (2022) MUC5AC and MUC5B Are Variably Packaged in the Same and in Separate Secretory Granules. Am. J. Resp. Crit. Care Med. 206, 1081-1095. *Equal contribution

 

298. REV. Ehre, C., Hansson, G. C., Thornton, D. J., Ostedgaard, and Ostedgaard, L. S. (2022) Mucus Aberrant Properties in CF: Insights from Cells and Animal Models. J. Cystic Fibrosis, on-line.

 

297. Dolan, B., Ermund, A., Martinez-Abad, B., Johansson, M. E.V. and Hansson, G. C. (2022) Clearance of small intestinal crypts involves goblet cell mucus secretion by intracellular granule rupture and enterocyte ion transport. Science Signaling, 15, eabl5848

 

296. PERSP. Johansson, M. E. V. and Hansson, G. C. (2022) Goblet cells need some stress. J. Clin. Invest. 132 (17), e162030.

 

295. Luis, A. S., Basle, A., Byrne, D. P., Wright, G. S. A., London, J. A., Jin, C., Karlsson, N. G., Hansson, G. C., Eyers, P. A., Czjzek, M., Barbeyron, T., Yates, E. A., Martens, E. C., and Cartmell, A. (2022) Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. Nature Chemical Biology 18, 841-849.

 

294. Sharpen, J. D. A., Dolan, B., Nyström, E. E. L., Birchenough, G. M. H., Arike, L., Martinez-Abad, B., Johansson, M. E. V., Hansson, G. C. and Recktenwald, C. V. (2022) Transglutaminase 3 crosslinks  the secreted MUC2 mucin  and stabilizes the colonic mucus layer. Nature Communications, 13, doi.org/10.1038/s41467-021-27743-1.

 

293. REV. Dolan, B. and Hansson, G. C. (2022) Mucins. Encyclopedia in Cell Biology 2d. https://doi.org/10.1016/B978-0-12-821618-7.00005-5

 

292. Ermund, A., Meiss, L. N., Dolan, B., Jaudas, F., Ewaldsson, L., Bähr, A., Klymiuk, N., and Hansson, G. C. (2021) Mucus threads from surface goblet cells clear particles from the airways. Respiratory Research 22(1), 303.

 

291. Sheikh, A., Wangdi, T., Vickers, T. J., Aaron, B., Palmer, M., Miller, M. J., Kim, S., Herring, C., Simoes, R., Crainic, J. A., Gildersleeve, J. C., van der Post, S., Hansson, G. C., and Fleckenstein, J. M. (2021) Enterotoxigenic Escherichia coli degrades the host MUC2 mucin barrier to facilitate critical pathogen-enterocyte interactions in human small intestine. Infection Immunity 90, e00572-21.

 

290. Luis, A. S., Jin, C., Pereira, G., Glowaki, R., Gugel, S., Sing, S., Byrne, D. P., Pudlo, N., London, J., Baslé, A., Reihill, M., Oscarsson, S., Karlsson, N. G., Eyres, P., Czjzek, M., Michel, G., Barbeyron, T., Yates, E. A., Hansson, G. C., and Martens, E. C. (2021) A single sulfatase is required for metabolism of colonic mucin O-glycans and intestinal colonization by a symbiotic human gut bacterium. Nature 598, 332-337.

 

289. Ehrencrona, E., van der Post, S., Gallego, P., Recktenwald, C. V., Rodriguez-Pineiro, A. M., Garcia-Bonete, M. J., Trillo-Muyo, S., Backstrom, M., Hansson, G. C., and Johansson, M. E. V. (2021) The IgG Fc-binding protein FCGBP is secreted with all GDPH sequences cleaved, but maintained by inter-fragment disulfide bonds. J. Biol. Chem. 297, 100871.

 

288. Giorgetti, Melania, Klymiuk, Nikolai, Bähr, Andrea, Hemmerling, Martin, Jinton, Lisa, Tarran, Robert, Malmgren, Anna, Åstrand, Annika, Hansson, G. C., and Ermund, Anna. (2021) New generation ENaC inhibitors detach cystic fibrosis airway mucus bundles via sodium/hydrogen exchanger inhibition. European J. Pharm. 904, 174123.

 

287. Nystrom, E. E. L., Martinez-Abad, B., Arike, L., Birchenough, G. M. H., Nonnecke, E. B., Castillo, P. A., Svensson, F., Bevins, C. L., Hansson, G. C., and Johansson, M. E. V. (2021) An intercrypt subpopulation of goblet cells are essential for colonic mucus barrier function. Science 372, 257.

 

286. Schroeder, B. O., Birchenough, G. M. H., Pradhan, M., Nystrom, E. E. L., Henricsson, M., Hansson, G. C., and Backhed, F. (2020) Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice. J. Biol. Chem. 296, 15712-15726.

 

285. REV: Hansson, G. C. (2020) Mucins and the Microbiome. Annual Rev. Biochem. 89, 769-793.

 

284. Arike, L., Hansson, G. C., and Recktenwald, C. V. (2020) Identifying transglutaminase reaction products via mass spectrometry as exemplified by the MUC2 mucin - Pitfalls and traps. Anal. Biochem. 597, 113668.

 

283. Fakih, D., Rodriguez Pineiro, A. M., Trillo-Muyo, S., Evans, C. M., Ermund, A., and Hansson, G. C. (2020) Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin. Am. J. Physiol. Lung Cell Mol. Physiol, 318, L1270-L1279.

 

282. Jabbar, K. S., Dolan, B., Eklund, L., Wising, C., Ermund, A., Johansson, A., Tornblom, H., Simren, M., and Hansson, G. C. (2020) Association between Brachyspira and irritable bowel syndrome with diarrhoea. Gut, 70, 1117-1129.

 

281. REV: Pelaseyed, Thaher and Hansson, Gunnar C. (2020) Membrane mucins of the intestine at a glance. J. Cell Sci. 133(5), jcs240929.

 

280. Arike, Liisa, Seiman, Andrus, van der Post, Sjoerd, Rodriguez Pineiro, Ana M., Ermund, Anna, Schutte, Andre, Bäckhed, Fredrik, Johansson, Malin E. V., and Hansson, Gunnar C. (2020) Protein Turnover in Epithelial Cells and Mucus along the Gastrointestinal Tract Is Coordinated by the Spatial Location and Microbiota. Cell Reports 30(4), 1077-1087.

 

279. Nystrom, E. E. L., Arike, L., Ehrencrona, E., Hansson, G. C., and Johansson, M. E. V. (2019) CLCA1 forms non-covalent oligomers in colonic mucus and has MUC2-processing properties. J. Biol. Chem., 294, 17075-17089.

 

278. Volk, J.K., Abad, B.M., Nyström, E. E. L., Svensson, F., Jäverfelt, S., Hansson, G.C., Johansson, M. E. V., Birchenough, G. M. H. (2019) Inflammasome activity is not required for inner mucus layer formation or function in the distal colon. J. Exp. Med., 216, 2602-2618.

 

277. Schneider, H., Berger, E., Dolan, B., Martinez-Abad, B., Arike, L., Pelaseyed, T., and Hansson, G. C. (2019) The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane. Biochem. J., 476, 2281-2295.

 

276. Blacher, Eran, Bashiardes, Stavros, Shapiro, Hagit, Rothschild, Daphna, Mor, Uria, Dori-Bachash, Mally, Kleimeyer, Christian, Moresi, Claudia, Harnik, Yotam, Zur, Maya, Zabari, Michal, Brik, Rotem Ben-Zeev, Kviatcovsky, Denise, Zmora, Niv, Cohen, Yotam, Bar, Noam, Levi, Izhak, Amar, Nira, Mehlman, Tevie, Brandis, Alexander, Biton, Inbal, Kuperman, Yael, Tsoory, Michael, Alfahel, Leenor, Harmelin, Alon, Schwartz, Michal, Israelson, Adrian, Arike, Liisa, Johansson, Malin E. V., Hansson, Gunnar C., Gotkine, Marc, Segal, Eran, and Elinav, Eran. (2019) Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature 572, 474-480.

 

275. Vega, G., Guequen, A., Johansson, M. E. V., Arike, L., Martinez-Abad, B., Nystrom, E. E. L., Scudieri, P., Pedemonte, N., Millar-Buchner, P., Philp, A. R., Galietta, L. J., Hansson, G. C., and Flores, C. A. (2019) Normal Calcium-Activated Anion Secretion in a Mouse Selectively Lacking TMEM16A in Intestinal Epithelium. Frontiers in Physiology 10, 694.

 

274. Furter, M., Sellin, M. E., Hansson, G. C., and Hardt, W. D. (2019) Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract. Cell Reports 27(9), 2665-2678.

 

273. REV: Hansson, G. C. (2019) Mucus and mucins in diseases of the intestinal and respiratory tracts. J. Internal Medicine 285, 479-490.

 

272. van der Post, S, Jabbar, K. S., Birchenough, G., Arike, L., Akhtar, N., Sjövall, H., Johansson, M. E. V., and Hansson, G.C. (2019) Structural weakening of the colonic mucus barrier is an early event in ulcerative colitis pathogenesis. Gut 68, 2142-2151.

 

271. PERSP: Birchenough, G., Schroeder, B. O., Bäckhed, F., and Hansson, G. C. (2019) Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier. Gut Microbes 10, 246-250.

 

270. Svensson, F., Lang, T., Johansson, M. E. V., and Hansson, G. C. (2018) The central exons of the human MUC2 and MUC6 mucins are highly repetitive and variable in sequence between individuals. Scientific Reports 8, 17503.

 

269. REV: Ermund, A., Trillo-Muyo, S., and Hansson, G. C. (2018) Assembly, Release, and Transport of Airway Mucins in Pigs and Humans. Ann. Am. Thorac. Soc. 15, S159-S163.

 

268. Fernández-Blanco, J. A., Fakih, D., Arike, L., Rodríguez-Pineiro, A., Martinez-Abad, B., Skansebo, E., Jackson, S., Root, J., Singh, D., McCrae, C., Evans, C. M., Astrand, A., Ermund, A., and Hansson, G. C. (2018) Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs. J. Clin. Invest. Insights 3, e120994.

 

267. Ermund, A., Meiss, L. N., Dolan, B., Bahr, A., Klymiuk, N., and Hansson, G. C. (2018) The mucin bundles responsible for airway cleaning are retained in cystic fibrosis and by cholinergic stimulation. Eur. Resp. J. 52(2), 1800457.

 

266. Nystrom, E. E. L., Birchenough, G. M. H., van der Post, S., Arike, L., Gruber, A. D., Hansson, G. C., and Johansson, M. E. V. (2018) Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity. EBioMed. 33, 134-143.

 

265. Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bahr A, Klymiuk N, Wine JJ, Koeck PJ, Thornton DJ, Hebert H, Hansson GC (2018) Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers.. J. Biol. Chem. 293, 5746-5754.

 

264. Jabbar, Karolina S., Arike, Liisa, Verbeke, Caroline S., Sadik, Riadh, and Hansson, Gunnar C. (2018) Highly Accurate Identification of Cystic Precursor Lesions of Pancreatic Cancer Through Targeted Mass Spectrometry: A Phase IIc Diagnostic Study. J. Clin. Oncology 36 367-375.

 

263. Wichert, Rielana, Ermund, Anna, Schmidt, Stefanie, Schweinlin, Matthias, Ksiazek, Miroslaw, Arnold, Philipp, Knittler, Katharina, Wilkens, Frederike, Potempa, Barbara, Rabe, Bjorn, Stirnberg, Marit, Lucius, Ralph, Bartsch, Jurg W., Nikolaus, Susanna, Falk-Paulsen, Maren, Rosenstiel, Philip, Metzger, Marco, Rose-John, Stefan, Potempa, Jan, Hansson, Gunnar C., Dempsey, Peter J., and Becker-Pauly, Christoph. (2017) Mucus Detachment by Host Metalloprotease Meprin β; Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB. Cell Reports 21, 2090-2103.

 

262. Schroeder, B. O., Birchenough, G. M.H., Ståhlman, M., Arike, L., Johansson, M. E.V., Hansson, G. C. and Bäckhed, F. (2018) Bifidobacterium and fiber protect against diet-induced deterioration of the inner colonic mucus layer. CELL Host & Microbe, 23, 1-14

 

261. REV: Wine, J. J., Hansson, G. C., Konig, P., Joo, N. S., Ermund, A., and Pieper, M. (2017) Progress in understanding mucus abnormalities in cystic fibrosis airways. J. Cystic Fibrosis 17, S35-S39.

 

260. Ermund, A., Meiss, L. N., Rodriguez-Pineiro, A. M., Bähr, A., Nilsson, H. E., Trillo-Muyo, S., Ridley, C., Thornton, D. J., Wine, J. J., Hebert, H., Klymiuk, N., and Hansson, G. C. (2017) The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin. Biochem. Biophys. Res. Commun. 492, 331-337.

 

259. PERS. Birchenough, G.M.H. and Hansson, G.C. (2017) Bacteria Tell Us How to Protect Our Intestine. CELL Host & Microbe 22, 3-4.

 

258. Ermund, A., Recktenwald, C. V., Skjak-Braek, G., Meiss, L. N., Onsoyen, E., Rye, P. D., Dessen, A., Myrset, A. H., and Hansson, G. C. (2017) OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating calcium. Clin. Exp. Pharmacol. Physiol., 44, 639-647.

 

257. Birchenough, G.M.H., Dalgakiran, F., Witcomb, L. A., Johansson, M. E. V., McCarthy, A. J., Hansson, G. C. and. Taylor, P. W. (2017) Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection. Sci. Rep. 7, 83

 

256. Bosmans, J. W. A. M., Jongen, A. C. H. M., Birchenough, G. M. H., Nystr+Âm, E. E. L., Gijbels, M. J. J., Derikx, J. P. M., Bouvy, N. D., and Hansson, G. C. (2017) Functional mucous layer and healing of proximal colonic anastomoses in an experimental model. Brit. J. Surgery , 104, 619-630.

 

255. Arike, L., Holmén-Larsson, J., and Hansson G.C. (2017) Intestinal Muc2 mucin O-glycosylation is affected by microbiota and regulated by differential expression of glycosyltranferases. Glycobiology, 27, 318-328

 

254. Bergström, J. H., Birchenough, G. M. H., Katona, G., Schroeder, B. O., Schutte, A., Ermund, A., Johansson, M. E. V., and Hansson G. C. (2016) Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc. Natl. Acad. Sci. USA 113, 13833-13838.

 

253. Birchenough, G. M. H., Nystrom, E. L. N., Johansson, M. E. V., and Hansson G. C. (2016) A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion. Science 352, 1535-1542.

 

252. REV: Johansson, M. E. V. and Hansson, G. C. (2016) Immunological aspects of intestinal mucus and mucins. Nature Rev.Immunol. 16, 639-649.

 

251. Lang, T., Klasson, S., Larsson, E., Johansson, M. E. V., Hansson, G. C., and Samuelsson T. (2016) Searching the Evolutionary Origin of Epithelial Mucus Protein Components; Mucins and FCGBP. Mol. Biol. Evolution, 33, 1921-1936

 

250. REV: Johansson, M. E. V. and Hansson, G. C. (2016) The Mucins. Encyclopedia Immunobiology 2, 381-388.

 

249. Recktenwald, C. V. and Hansson, G. C. (2016) The reduction-insensitive bonds of the MUC2 mucin are isopeptide bonds. J. Biol. Chem. 249, 13580-13590.

 

248. Bergstrom, K., Fu, J., Johansson, M. E., Liu, X., Gao, N., Wu, Q., Song, J., McDaniel, J. M., McGee, S., Chen, W., Braun, J., Hansson, G. C., and Xia. (2016) L. Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice. Mucosal Immunol. 10, 91-103.

 

247. REV: Arike, L. and Hansson, G.C. (2016) The Densely O-glycosylated MUC2 Mucin Protects the Intestine and Provides Food for the Commensal Bacteria. J. Mol. Biol. 428, 3221-3229.

 

246. Earle, K. A., Billings, G., Sigal, M., Lichtman, J. S., Hansson, G. C., Elias, J. E., Amieva, M. R., Huang, K. C., and Sonnenburg, J. L. (2015) Quantitative Imaging of Gut Microbiota Spatial Organization. Cell Host Microbe 18, 478–488, 478–488.

 

245. Johansson, M. E. V., Jacobsson, H. E., Holmén-Larsson, J., Schütte, A., Ermund, A., Rodriguez-Pineiro, A., Arike, L., Wising, C., Svensson, F., Bäckhed, F., and Hansson G. C. (2015) Normalization of the host intestinal mucus systems requires long-term colonization. CELL Host Microbe 18: 582-592.

 

244. Ermund, A., Meiss, L. N. Gustafsson, J. K., and Hansson, G. C. (2015) Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus.  Eur J Pharmacol. 764: 109-117.

 

243. Wenzel, U. A., Jonstrand, C., Hansson, G. C., and Wick, M. J. (2015) CD103+CD11b+ dendritic cells induce TH17 T cells in Muc2-deficient mice with extensively spread colitis. PLoS ONE 10: e0130750.

 

242. Hickey, C. A., Kuhn, K. A., Donermeyer, D. L., Porter, N. T., Jin, C., Cameron, E. A., Jung, H., Kaiko, G. E., Wegorzewska, M., Malvin, N. P., Glowacki, R. W., Hansson, G. C., Allen, P. M., Martens, E. C., and Stappenbeck T. S. (2015) Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles. CELL Host Microbe. 17, 672-680.

 

241. REV: Birchenough, G. M. H., Johansson, M. E. V., Gustafsson, J.K., Bergstrom, J.H., and Hansson, G. C. (2015) New developments in goblet cell mucus secretion and function. Mucosal Immunol. 8: 712-719

 

240. Hannan, T.J., Roberts, P.J., Riehl, T.E., van der Post, S., Binkley, J. M., Schwartz, D.J., Miyoshi, H., Mack, M., Schwendener, R.A., Hooton, T.M., Stappenbeck, T.S., Hansson, G.C., Stenson, W.F., Colonna, M., Stapleton, A.E. and Hultgren, S.J. (2014) Inhibition of cyclooxygenase-2 prevents chronic and recurrent bladder infection. EBioMedicine, 2014.10.011

 

239. van der Post, S., Thomsson, K.A., and Hansson, G. C. (2014) A multiple enzyme approach for the characterization of glycan modifications on the C-Terminus of the intestinal MUC2 mucin. J. Proteome Res., 13, 6013-6023.

 

238. Ermund, A., Meiss, L., Scholte, B. J., and Hansson G. C. (2015) Hypertonic saline releases the attached small intestinal cystic fibrosis mucus. Clin. Exp. Pharm. Physiol. 42, 69-75.

 

237. Gustafsson, J. K., Linden, S. K., Alwan, A. H., Scholte, B. J., Hansson, G. C., and Sjovall, H. (2015) Carbachol-induced colonic mucus formation requires transport via NKCC1, K channels and CFTR. Pflugers Arch., DOI 10.1007/s00424-014-1595-y.

 

236. Sadio, A. Gustafsson, J. K, Pereira, B., Gomes, C.P., Hansson, G. C., David, L., Pego, A. P., and Almeida, R. (2014) Modified-Chitosan/siRNA Nanoparticles Downregulate Cellular CDX2 Expression and Cross the Gastric Mucus Barrier. PLoS ONE 9 (6):e99449.

 

235. Bergström, J. H., Berg, K. A., Rodriguez-Pineiro, A. M., Stecher, B., Johansson, M. E. V., and Hansson, G. C. (2014) AGR2, nn endoplasmic reticulum protein is secreted into the gastrointestinal mucus. PLoS ONE 9 (8):e104186.

 

234. van der Post, S. and Hansson, G.C. (2014). Membrane protein profiling of human colon reveals distinct regional differences. Mol. Cell. Proteomics 13, 2277-2287.

 

233. Jakobsson, H. E., Rodriguez-Pineiro, A. M., Schütte, A., Ermund, A., Boysen, P., Sommer, F., Bäckhed, F., Hansson, G. C., and Johansson M. E. V. (2015) The gut microbiota composition impairs the colon inner mucus layer barrier. EMBO Reports 16, 164-177.

 

232. Schütte, A., Ermund, A., Becker-Pauly, C., Johansson, M.E.V., Rodriguez-Pineiro, A. M., Bäckhed, Müller, F.S., Lottaz, D., Bond, J.S., and Hansson, G.C. (2014) Microbial Induced Meprin β Cleavage in MUC2 Mucin and Functional CFTR Channel are Required to Release Anchored Small Intestinal Mucus. Proc. Natl. Acad. Sci. USA 111, 12396-12401.

 

231. REV: Pelaseyed, T., Bergström, J. H., Gustafsson, J. K., Ermund, A., Birchenough, G. M. H., Schütte, A. van der Post, S, Svensson, F., Rodríguez-Piñeiro, A. M., Nyström, E. E.L., Wising, C., Johansson, M. E.V., and Hansson, G. C. (2014) The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol. Rev., 260, 8-20.

 

230. Wenzel, U.A., Magnusson, M. K., Rydström, A., Jonstrand, C., Hengst, J., Johansson, M.E.V., Velcich, A., Öhman, L., Strid, H., Sjövall, H., Hansson, G.C., and Wick, M.J. (2014) Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis. PLoS ONE, 9, e100217.

 

229. Nilsson, H. E., Ambort, D., Backstrom, M., Thomsson, E., Koeck, P. J., Hansson, G. C., and Hebert, H. (2014) Intestinal MUC2 mucin supramolecular topology by packing and release resting on D3 domain assembly. J. Mol. Biol. 426, 2567-2579

 

228. Jabbar, K. S., Verbeke, C., Hyltander, A. G., Sjovall, H., Hansson, G. C., and Sadik, R. (2014) Proteomic Mucin Profiling for the Identification of Cystic Precursors of Pancreatic Cancer. J. Natl. Cancer Inst. 106, djt439. IMPACT 14.3

 

227. PERSP. Johansson, M.E.V. and Hansson, G.C. (2014) Is the intestinal goblet cell a major immune cell? CELL Host & Microbe, 15, 251-252.

 

226. Xiao, F., Yu, Q., Li, J., Johansson, M. E., Singh, A. K., Xia, W., Riederer, B., Engelhardt, R., Montrose, M., Soleimani, M., Tian, D. A., Xu, G., Hansson, G. C., and Seidler, U. (2014) Slc26a3 deficiency is associated with loss of colonic HCO secretion, absence of a firm mucus layer, and barrier impairment in mice. Acta Physiol (Oxf), 211, 161-175.

 

225. Sommer, F., Adam, N., Johansson, M. E. V., Xia, L., Hansson, G. C., and Bäckhed, F. (2014) Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture. PLoS ONE 9, e85254

 

224. Gustafsson, J. K., Navabi, N., Rodriguez-Pineiro, A. M., Alomran, A. H. A., Premaratne, P., Fernandez, H. R., Banerjee, D., Sjövall, H., Hansson, G. C., and Lindén, S. K. (2013) Dynamic changes in mucus thickness and ion secretion during Citrobacter rodentium infection and clearance. PLoS ONE 8, e84430

 

223. Ermund, A., Gustafsson, J. K., Hansson, G. C., and Keita, Å. A. (2013) Mucus properties and goblet cell quantification in mouse, rat, and human ileal Peyer's patches PLoS ONE, 8, e83688

 

222. PERSP. Johansson, M. E. V. and Hansson, G. C. (2013) Mucus and the Goblet Cell. Digestive Dis., 31, 305-309.

 

221. Birchenough, G. M. H., Johansson, M. E. V., Stabler, R. A., Dalgakiran, F., Hansson, G. C., Wren, B. W., Luzio, J. P., and Taylor, P. W. (2013) Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia coli. Infect. Immun. 81, 3264-3275.

 

220. Pelaseyed, T., Gustafsson, J. K., Gustafsson, I. J., Ermund, A., and Hansson, G. C. (2013) Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes. Am. J. Physiol. Cell Physiol. 305, C457-C467.

 

219. Holmen-Larsson, J. M., Thomsson, K. A., Rodriguez-Pineiro, A. M., Karlsson, H., and Hansson, G. C. (2013) Studies of mucus in mouse stomach, small intestine, and colon. III. Gastrointestinal Muc5ac and Muc2 mucin O-glycan patterns reveal a regiospecific distribution. Am. J. Physiol. Gastroint. Liver. Physiol.G357-G363.

 

218. Rodriguez-Pineiro, A. M., Bergstrom, J. H., Ermund, A., Gustafsson, J. K., Schutte, A., Johansson, M. E. V., and Hansson, G. C. (2013) Studies of mucus in mouse stomach, small intestine, and colon. II. Gastrointestinal mucus proteome reveals Muc2 and Muc5ac accompanied by a set of core proteins Am. J. Physiol. Gastroint. Liver Physiol. 305, G348-G356.

 

217. Ermund, A., Schutte, A., Johansson, M. E. V., Gustafsson, J. K., and Hansson, G. C. (2013) Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer’s patches. Am. J. Physiol. Gastroint. Liver Physiol. 305, G341-G347.

 

216. Liu, C., Xu, H., Zhang, B., Johansson, M. E., Li, J., Hansson, G. C., and Ghishan, F. K. (2013) NHE8 plays an important role in mucosal protection Via its effect on bacterial adhesion. Am. J. Physiol. Cell Physiol. 305, C121-C128.

 

215. van der Post, S., Subramani, D.B., Malin Bäckström, M., Johansson, M.E.V., Vester-Christensen, M.B., Mandel, U., Bennett, E.P., Clausen, H., Dahlén, G., Sroka, A., Potempa, J., and Hansson, G.C. (2013) Site-specific O-glycosylation on the MUC2 mucin inhibits cleavage by the Porphyromonas gingivalis secreted cysteine protease (RgpB). J. Biol. Chem. 288, 14636-14646.

 

214. REV: Johansson, M. E. V., Sjovall, H., and Hansson, G. C. (2013) The gastrointestinal mucus system in health and disease. Nature Rev. Gastroenterol.Hepatol. 10, 352-361.

 

213. Johansson, M. E. V., Gustafsson, J. K., Holmen-Larsson, J., Jabbar, K. S., Xia, L., Xu, H., Ghishan, F. K., Carvalho, F. A., Gewirtz, A. T., Sjövall, H., and Hansson, G. C. (2014) Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and in patients with ulcerative colitis. Gut 63, 281-291. IMPACT 14.9

 

212. REV: Bäckström, M., Ambort, D., Thomsson, E., Johansson, M. E. V., and Hansson, G. C. (2012) Increased Understanding of the Biochemistry and Biosynthesis of MUC2 and Other Gel-Forming Mucins Through the Recombinant Expression of Their Protein Domains. Mol. Biotechnol. DOI 10.1007/s12033-012-9562-3.

 

211. Pelaseyed, T., Zäch, M., Petersson, A. C., Svensson, F., Johansson, D. G., and Hansson, G. C. (2013) Unfolding dynamics of the mucin SEA domain probed by force spectroscopy suggest that it acts as a cell protective device. FEBS J. 280, 1491-1501.

 

210. Arampatzidou, M., Schütte, A., Hansson, G.C., Saftig, P., Brix, K. (2012) Effects of cathepsin K deficiency on intercellular junction proteins, luminal mucus layers, and extracellular matrix constituents in the mouse colon. Biol. Chem. 393, 1391-1403

 

209. B Ambort, D., Johansson, M.E.V., Gustafsson, J.K., Ermund, A., and Hansson G.C. (2012) Perspectives on Mucus Properties and Formation - Lessons from the Biochemical World. Cold Spring Harbor Perspectives in Medicine. 2(11), a014159

 

208. L Ambort, D. and Hansson, G.C. (2012) Reply to Verdugo: Mucins form highly organized supramolecular structures. Proc.Natl.Acad.Sci.U.S.A. 109, E2956-2957

 

207. Breimer ME, Hansson GC, Karlsson KA, Larson G, and Leffler H. (2012) Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human individual. Glycobiology, 22, 1721-1730

 

206. Thomsson, K.A., Holmén-Larsson, J., Ångström, J., Johansson, M.E.V., Xia, L., and Hansson, G.C. (2012) Detailed O-glycomics of the Muc2 mucin from colon of wild-type, core 1- and core 3-transferase-deficient mice highlights differences compared with human MUC2. Glycobiology 22, 1128-1139

 

205. PERSP. Johansson, M.E.V. and Hansson, G.C. (2013) The goblet cell: a key player in ischemia-reperfusion injury. Gut 62, 188-189

 

204. Gustafsson, J.K., Hansson, G. C., and Sjövall, H. (2012) Ulcerative colitis patients in remission have an altered secretory capacity in the proximal colon despite macroscopically normal mucosa. Neurogastroenterol Motil, 24, e381-e391

 

203. Gustafsson, J.K., Ermund, A., Ambort, D., Johansson, M.E.V., Nilsson, H.E., Thorell, K., Hebert, H., Sjövall, H., and Hansson, G. C. (2012) Bicarbonate and functional CFTR channel are required for proper mucin secretion and link Cystic Fibrosis with its mucus phenotype. J. Exp. Med., 209, 1263-1272

      

202. Ambort, D., Johansson, M. E. V., Gustafsson, J. K., Nilsson, H., Ermund, A., Johansson, B. R., Kock, P., Hebert, H., and Hansson, G. C. (2012) Calcium and pH-dependent Packing and Release of the Gel-forming MUC2 Mucin. Proc. Natl. Acad. Sci. USA. 109, 5645-5650

 

201. Rodriguez-Pineiro, A.M., van der Post, S., Johansson, M.E.V., Thomsson, K.A., Nesvizhskii, A.I., and Hansson, G.C. (2012) Proteomic study of the mucin granulae in an intestinal goblet cell model. J. Proteome Res. 11, 1879-1890

 

200. Johansson, M.E.V., Hansson, G.C. (2012) Preservation of Mucus in Histological Sections, Immunostaining of Mucins in Fixed Tissue, and Localization of Bacteria with FISH. Methods Mol. Biol. 842, 229-235

 

199. Gustafsson, J.K., Sjövall, H., Hansson, G.C. (2012) Ex vivo measurements of mucus secretion by colon explants. Methods Mol. Biol. 842, 237-243

 

198. Johansson, M.E.V., Hansson, G.C. (2012) Analysis of assembly of secreted mucins. Methods Mol. Biol. 842, 109-121

 

197. REV: Hansson, G.C. (2012) Role of mucus layers in gut infection and inflammation. Curr. Opinion Microbiol. 15, 57-62.

 

196. Gustafsson, J. K., Ermund, A., Johansson, M. E. V., Schutte, A., Hansson, G. C., and Sjovall, H. (2012) An ex vivo method for studying mucus formation, properties and thickness in human colonic biopsies and mouse small and large intestinal explants. Am. J. Physiol. Gastrointest. Liver Physiol. 302. G430-G438.

 

195. PERSP. Johansson, M. E. V. and Hansson, G. C. (2011) Keeping Bacteria at a Distance. Science 334, 182-183.

 

193. Songhet, P., Barthel, M., Stecher, B., Müller, A.J., Kremer, M., Hansson, G.C., Hardt W.D. (2011) Stromal IFN-γR-Signaling Modulates Goblet Cell Function During Salmonella Typhimurium Infection. PLoS ONE. 2011;6(7):e22459.

 

192. Thomsson, K.A., Hansson, G.C. (2011) Identification and quantification of mucin expression. Methods Mol. Biol. 742, 127-141.

 

191. Pelaseyed, T. and Hansson, G. C. (2011) CFTR anion channel modulates expression of human transmembrane mucin MUC3 via the PDZ protein GOPC. J. Cell Sci. 124, 3074-3083 IMPACT 5.9

 

190. Thomsson, E., Persson, L., Grahn, A., Snäll, J., Ekblad, M., Brunhage, E., Svensson, F., Hansson, G.C., Bäckström, M. and Bergström, T. (2011) Recombinant glycoprotein E produced in mammalian cells in large-scale as an antigen for varicella-zoster-virus-serology. J. Virol. Meth., 175, 53-59.

189. Ambort, D., van der Post, S., Mackenzie, J., Johansson, M.E.V., Thomsson, E., Krengel, U., and Hansson, G.C. (2011) Function of the CysD domain of the gel-forming MUC2 mucin. Biochem. J. 436, 61-70.

188. B Bäckström, M., Karlsson, H., Gätgens, J., Noll, T., and Hansson, G. C. (2010) O-glycans on recombinant MUC1 produced in CHO K1 cells become less sialylated with increased protein productivity, as determined by LC-ESI MS in Cells and Culture (Noll, T., ed.) pp. 285-288, Springer

 

187. Fu, J., Wei, B., Wen, T., Johansson, M.E.V., Xiaowei Liu, X., Bradford, E., Thomsson, K.A., McGee, S., Mansour, L., Tong, M., McDaniel, M., Sferra, T. J., Turner, J. , Chen, H. , Hansson, G. C., Braun, J. ,Xia, L. (2011) Loss of intestinal core 1–derived O-glycans causes spontaneous colitis. J. Clin. Invest., 121, 1657-1666.

 

186. Subramani, D. B., Johansson, M. E.V., Dahlén, G., and Hansson, G. C. (2010) Probiotic Lactobacillus and Bifidobacterium species do not secrete proteases that can cleave the MUC2 mucin protein core which organizes the colon mucus layers. Beneficial Microbes 1, 343-350.

 

185. Petersson, J., Schreiber, O.,. Hansson, G.C, Gendler, S.J., Velcich, A., Lundberg, J., Roos, S., Holm, L., and Phillipson, M. (2010) Importance and Regulation of the Colonic Mucus Barrier in a Mouse Model of Colitis. Am. J. Physiology, 300, G327-G333

 

184. Premaratne, P. Welén, K., Damber, J.-E., Hansson, G.C. and Bäckström M. (2011) O-glycosylation of MUC1 mucin in prostate cancer and the effects of its expression on tumor growth in a prostate cancer xenograft model. Tumor Biol. 32, 203-213.

 

183. Johansson, M.E.V. Gustafsson, J.K., Sjöberg, K. E., Petersson, J., Holm, L., Sjövall, H. and Hansson, G.C. (2010) Bacteria penetrate the inner mucus layer before inflammation in the Dextran sulfate colitis model. PLOS One, 5, e12238

 

182. PERSP. Hansson, G.C. (2010) Sparkling Water - Bicarbonate for Cervix and Cystic Fibrosis. Perspective, J. Physiol. 588, 2685

 

181. Johansson, M.E.V., Holmén Larsson, J. M., and Hansson G. C. (2011) The two mucus layers of colon are organized by the MUC2 mucin – the outer layer is a legislator of host-microbial interactions. Proc. Natl. Acad. Sci. USA 108, 4659-4665.

 

180. Holmén Larsson, J. M. Karlsson, H., Gråberg Crespo, J., Johansson, M. E. V., Eklund, L., Sjövall, H., and Hansson, G. C. (2011) An Altered O-glycosylation Profile of the MUC2 Mucin Occurs in Active Ulcerative Colitis and is Associated with Increased Inflammation. Infl. Bowel Dis., 17, 2299-2307

 

179. Thomsson, K. A., Bäckström, M., Holmen-Larsson, J., Hansson, G. C., and Karlsson, H. (2010) Enhanced detection of sialylated and sulfated glycans with negative ion mode nanoliquid chromatography/mass spectrometry at high pH. Anal. Chem. 82, 1470–1477

 

178. Wada, Yoshinao, Dell, Anne, Haslam, Stuart M., Tissot, Berangere, Canis, Kevin, Azadi, Parastoo, Backstrom, Malin, Costello, Catherine E., Hansson, Gunnar C., Hiki, Yoshiyuki, Ishihara, Mayumi, Ito, Hiromi, Kakehi, Kazuaki, Karlsson, Niclas, Kato, Koichi, Kawasaki, Nana, Khoo, Kay Hooi, Kobayashi, Kunihiko, Kolarich, Daniel, Kondo, Akihiro, Lebrilla, Carlito, Nakano, Miyako, Narimatsu, Hisashi, Novak, Jan, Novotny, Milos V., Ohno, Erina, Packer, Nicolle H., Renfrow, Matthew B., Tajiri, Michiko, Thomsson, K. A., Yagil, H., Yu, S.-Y., and Taniguchi, Naoyuki. (2009) Comparison of Methods for Profiling O-glycosylation: HUPO Human Disease Glycomics/Proteome Initiative Multi-Institutional Study of IgA1. Molecular Cellular Proteomics, 9, 719-727

 

177. REV: Hansson, G. C. and Johansson, M. E. V. (2010) The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Gut Microbes 1, 10-14.

 

176. Persson, J., Backstrom, M., Johansson, H., Jirstrom, K., Hansson, G. C., and Ohlin, M. (2009) Molecular Evolution of Specific Human Antibody against MUC1 Mucin Results in Improved Recognition of the Antigen on Tumor Cells. Tumor Biol. 30, 221-231.

 

175. Domino, S. E., Hurd, E. A., Thomsson, K. A., Karnak, D. M., Holmén-Larsson J. M., Thomsson, E., Bäckström, M., and Hansson, G.C. (2009) Cervical Mucins Carry α(1,2)Fucosylated Glycans that Partly Protect from Experimental Vaginal Candidiasis. Glycoconj. J. 26, 1125-1134.

 

174. Johansson, M.E.V., Thomsson, K.A., and Hansson, G.C. (2009) Proteomic Analyses of the Two Mucus Layers of the Colon Barrier Reveal That Their Main Component, the Muc2 Mucin, Is Strongly Bound to the Fcgbp Protein. J. Proteome Res, 8, 3549-3557

 

173. Holmén Larsson, J. M. Karlsson, H., Sjövall, H. and Hansson, G. C. (2009) A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn. Glycobiology, 19, 756-766.

 

172. Backstrom M, Thomsson KA, Karlsson H, Hansson GC. (2008) Sensitive Liquid Chromatography-Electrospray Mass Spectrometry Allows for the Analysis of the O-Glycosylation of Immunoprecipitated Proteins from Cells or Tissues: Application to MUC1 Glycosylation in Cancer. J Proteome Res. 8, 538-545.

 

171. Sihlbom C, van Dijk Härd I, Lidell ME, Noll T, Hansson GC, Bäckström M. (2009) Localisation of O-glycans in MUC1 glycoproteins using electron-capture dissociation fragmentation mass spectrometry. Glycobiology, 19: 375-381.

 

170. Johansson, M.E.V., Phillipson, M., Petersson, J., Holm, L., Velcich, A. and Hansson, G.C. (2008) The inner of the two Muc2 mucin dependent mucus layers in colon is devoid of bacteria. Proc. Natl. Acad. Sci USA, 105, 15064-15069.

 

169. Phillipson, M., Johansson, M.E.V., Henriksnäs, J., Petersson, J., Gendler, S.J., Sandler, S., Persson, A.E.G., Hansson, G.C. and Holm, L (2008) The gastric mucus layers: constituents and regulation of accumulation. Am. J. Physiol. Gastrointest. Liver Physiol. 295: G806 - G812.

 

168. Karlsson, H., Holmén Larsson, J. M. Thomsson, K.A., Härd, I., Bäckström, M., and Hansson, G. C. (2009) High-throughput and high-sensitivity nano-LC/MS and MS/MS for O-glycan profiling. Methods Mol. Biol. 534: 1-15.

 

167. Lidell, M., Bara, J. and Hansson, G.C. (2008) Mapping of the 45M1 epitope to the C-terminal cysteine-rich part of the human MUC5AC mucin. FEBS J. 275, 481-489.

 

166. Malmberg, E.K., Pelaseyed, T., Petersson, Å.C., Seidler, U.E., de Jonge, H., Riordan, J.R., and Hansson, G.C. (2008) The Transmembrane MUC17 Mucin C-terminus Binds to the Scaffold Protein PDZK1 that Stably Localizes it to the Enterocyte Apical Membrane in the Small Intestine. Biochem. J. 410, 283-289.

 

165. Lang, T., Hansson, G. C., and Samuelsson, T. (2007) Gel-forming mucins appeared early in metazoan evolution. Proc. Natl. Acad. Sci. USA, 104, 16209-16214.

 

164. Kadaja-Saarepuu, L., Laos S., Jääger, K., Viil, J., Balikova, A., Lõoke, M., Hansson, G. C., and Maimets, T. (2008) CD43 promotes cell growth and helps to evade FAS-mediated apoptosis in nonhematopoietic cancer cells lacking the tumor suppressors p53 or ARF. Oncogene, 27, 1705-1715.

 

163. Andersch-Björkman, Y, Thomsson, K. A., Holmén Larsson, J. M., Ekerhovd, E., and Hansson, G. C. (2007) Large-scale Identification of Proteins, Mucins and their O-glycosylation in the Endocervical Mucus during the Menstrual Cycle. Mol. Cell Proteomics 6, 708-716 (Impact: 9.9)

 

162. Braun, F.N. and Hansson, G.C. (2006) Internal repeat variability in mucin sequences. Biomacromolecules, 7, 3542-3543

 

161. Lang, T., Hansson, G.C., and Samuelsson, T. (2006) An inventory of mucin genes in the chicken genome shows that the mucin domain of Muc13 is encoded by multiple exons and that ovomucin is part of a locus of related gel-forming mucins. BMC Genomics 7, 97.

 

160. Lidell, M. and Hansson, G.C. (2006) Cleavage in the GDPH sequence of the C-terminal Cysteine-rich Domain of the Human MUC5AC mucin. Biochem. J. 399, 121-129.

 

159. Lidell, M., Moncada, D., Chadee, K., and Hansson, G.C. (2006) Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal part and dissolves the protective colonic mucus gel. Proc Natl Acad Sci USA, 103, 9298-9303.

 

158. Malmberg, E., Noaksson, K. A., Phillipson, M., Johansson, M.E.V., Hinojosa-Kurtzberg, M., Holm, L., Gendler, S.J. and Hansson, G.C. (2006) Increased levels of mucins in the cystic fibrosis mouse small intestine and modulator effects of the Muc1 mucin expression. Am. J. Physiol. Gastrointest. Liver Physiol. 291, G203-G210.

 

157. Sewell, R., Backstrom, M., Dalziel, M., Gschmeissner, S., Karlsson, H., Noll, T., Gatgens, J., Clausen, H., Hansson, G. C., Burchell, J., Taylor-Papadimitriou, J. (2006) The ST6GalNAc-I sialyltransferase localises throughout the Golgi and is responsible for the synthesis of the tumour associated sialyl Tn O-glycan in human breast cancer. J. Biol. Chem. 281, 3586-3594.

 

156. Laos, S., Baeckström, D., and Hansson, G.C. (2006) Inhibition of NF-κB activation and chemokine expression by the leukocyte glycoprotein CD43 in colon cancer cells. Int. J. Oncology, 28, 695-704.

 

155. Macao, B., Johansson, D. G. A., Hansson, G.C. and Härd, T. (2006) Auto-proteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin. Nature Structural Molecular Biology, 13, 71-76.

 

154. Hurd, E. A., Holmén, J. M., Hansson, G. C., and Domino,S. E. (2005) Gastrointestinal Mucins of Fut2 Null Mice Lack Terminal Fucosylation without Affecting Colonization by Candida albicans. Glycobiology, 15:1002-1007.

 

153. Rughetti, A., Pellicciotta, I., Biffoni, M., Backstrom, M., Link, T., Bennet, E. P., Clausen, H., Noll, T., Hansson, G. C., Burchell, J. M., Frati, L., Taylor-Papadimitriou, J., and Nuti, M. (2005) Recombinant Tumor-Associated MUC1 Glycoprotein Impairs the Differentiation and Function of Dendritic Cells. J. Immunol. 174, 7764-7772.

 

152. REV: Hansson, G.C. (2005) Biosynthesis and secretion of mucins, especially the MUC2 mucin, in relation to Cystic Fibrosis. Adv. Exp. Med. Biol., 558, 169-178.

 

151. Andersson, C.X., Fernandez-Rodriguez, J., Laos, S., Baeckström, D., Haass, C., and Hansson, G.C. (2005) Shedding and γ-Secretase mediated intramembrane proteolysis of the mucin-type molecule CD43. Biochem. J. 387, 377–384.

 

150. Olson,F. J., Bäckström, M., Karlsson, H., Burchell, J., and Hansson, G. C. (2005) A MUC1 tandem repeat reporter protein produced in CHO K1 cells has sialylated core 1 O-glycans and becomes more densely glycosylated if co-expressed with polypeptide-GalNAc-T4 transferase. Glycobiology, 15, 177-191.

 

149. Malmberg, E. K., Andersson, C. X., Gentzsch, M., Chen, J. H., Cui, L., Hansson, G. C., and Riordan, J. R. (2004) BCR (breakpoint cluster region) protein binds the membrane associated PDZ-domain proteins PDZK1 and Mint3. J. Cell Sci. 117, 5535-5541.

 

148. Holmén, J., Karlsson, N.G., Abdullah, L. H., Randell, S. H., Sheehan, J. K., Hansson, G. C. and Davis, C. W. (2004) Mucins and their O-Glycans from Human Bronchial  Epithelial Cell Cultures. Am. J. Physiol., Lung, Cell and Mol. Physiol. 287, L824-L834.

 

147 REV:  Hansson, G.C. (2003) Glycomics - a complex challenge. The Biochemist 25, 11-13.

 

146.    Lang, T., Alexandersson, M., Hansson, G. C., and Samuelsson, T. (2004) Bioinformatic identification of polymerizing and transmembrane mucins in the puffer fish Fugu rubripes. Glycobiology 14. 521-527.

 

145.    Hattrup, C., Fernandez-Rodriguez, J., Schroder, J. A.., Hansson, G. C., and Gendler, S. J. (2004) MUC1 can interact with adenomatous polyposis coli in breast cancer. Biochem. Biophys. Res. Commun. 316, 364-369.

 

144.    Andersson, C. X., Fernandez-Rodriguez, J., Laos, S. Sikut, R., Sikut, A. Baeckström, D. and Hansson, G. C. (2004) CD43 has a functional NLS, interacts with β-catenin and affects gene expression. Biochem. Biophys. Res. Commun. 316, 12-17.

 

143.    Link, T., Bäckstrom, M., Graham R., Essers, R., Zörner, K., Gätgens, J., Burchell, J., Taylor-Papadimitriou, J., Hansson, G. C. and Noll. T. (2004) Bioprocess development of the production of a recombinant MUC1 fusion protein expressed by CHO-K1-cells in protein-free medium. J. Biotechnology, 110, 51-62.

 

142.    Sternberg, L. R., Byrd, J. C., Hansson, G. C., Liu, K.-F., Bresallier, R. S. (2004) Alternative splicing of the human MUC2 gene. Arch. Biochem. Biophys. 421, 21-33.

 

141.    Angstrom, J., Larsson, T., Hansson, G. C., Karlsson, K.-A., and Henry, S. (2004) Default biosynthesis pathway for the blood-group related glycolipids in human small intestine as defiend by structural identification of linear and branched glycosylceramides in group 0 Le(a-b-) nonsecretor. Glycobiology, 14, 1-12.

 

140.    Bäckström, M., Link, T., Olson, F.J., Karlsson, H., Graham, R., Burchell. J., Noll, T., Taylor-Papadimitriou, J., and Hansson, G.C. (2003) Recombinant MUC1 Mucin with a Breast Cancer-like O-glycosylation Produced in Large Amounts in CHO-K1 Cells. Biochemical J. 376, 677-686.

 

139.    Holmen, J.E., Olson, F.J., Karlsson, H. and Hansson, G.C. (2002) Mucin glycosylation alterations in mice due to intestinal infection by the parasite Nippostrongylus brasiliensis. Glycoconjugate J., 19, 67-75.

 

138.    Lidell, M., Johansson, M.E.V., and Hansson, G.C. (2003) An autocatalytic cleavage in the Human MUC2 Mucin C-terminus occurs at the low pH of the late secretory pathway. J. Biol. Chem. 278, 13944-13951.

 

137.    Hinojosa-Kurtzberg, M., Johansson, M. E.V., Madsen, C. S., Hansson, G. C., and Gendler, S. J. (2003) Novel MUC1 splice variants contribute to mucin over-expression in CFTR deficient mice. Am. J. Physiol. 284, G853-G862.

 

136.    Fernandez-Rodriguez, J., Andersson, C.X., Laos, S., Baeckström, D. Sikut, A., Sikut, R., and Hansson, G.C. (2002) The Leukocyte Antigen CD43 is Expressed in Different Cell Lines of Non-Hematopoietic Origin. Tumor Biology, 23, 193-201

 

135.    Fernandez-Rodriguez, J., Dwir, O., Alon, R. and Hansson, G.C. (2001, published 2003) Tumor cell MUC1 and CD43 are differently glycosylated with sialyl-Lewis a and x epitopes and show variable interactions with E-selectin under physiological flow conditions. Glycoconjugate J., 18, 925-930.

 

134.    Lidell, M., Johansson, M. E. V., Asker, N., Gum, J. R., Kim, Y. S. and Hansson, G.C. (2003) The recombinant C-terminus of the human MUC2 mucin forms dimers in CHO cells and heterodimers with full-length MUC2 in LS 174T cells. Biochem. J., 372:335-345

 

133.    Thomsson, K.A., Hinojosa-Kurtzberg, M., Axelsson, K.A. Domino, S.E. Lowe, J.B., Gendler, S.J., and Hansson, G.C. (2002) Intestinal Mucins from Cystic Fibrosis Mice show Increased Fucosylation due to an Induced Fuca1-2 Glycosyltransferase. Biochem. J., 367, 609–616

 

132.     Godl, K., Johansson, M. E. V., Karlsson, H., Mörgelin, M., Lidell, M.E., Olson, F.J., Gum Jr., J.R., Young S. Kim, Y.S. and Hansson, G.C. (2002) The N-termini of the MUC2 mucin form trimers that are held together within a trypsin-resistant core fragment. J. Biol. Chem., 277, 47248-47256

 

131.    Olson, F.J., Johansson, M.E.V., Klinga-Levan,K., L., Bouhours, D., Enerbäck, Hansson, G.C. and Karlsson, N.G. (2002) Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during Nippostrongylus Braseliensis parasite infection. J. Biol. Chem. 277, 15044-15052

 

130.    Thomsson, K. A., Prakobphol, A., Leffler, H., Reddy, M.S. Levine, M.J., Fisher, S.J. and Hansson, G.C. (2002) The Salivary Mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that are large and diverse. Glycobiology 12, 1-14.

 

129.    Axelsson, M.A.B., Karlsson, N.G., Steel, D., Ouwendijk, J., Nilsson, T. and Hansson, G.C. (2001) Neutralization of the pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins. Glycobiology, 11, 633-644.

 

128.    Thomsson, K.A., Karlsson, H. and Hansson, G.C. (2000) Sequencing of Sulfated Oligosaccharides from Mucins by Liquid Chromatography and Electrospray Ionization Tandem Mass Spectrometry. Anal. Chem., 72, 4543-4549.

 

127.    Karlsson, N. G., Olson, F. J., Jovall, P.-Å., Andersch, Y., Enerbäck, L. and Hansson, G. C. (2000) Identification of transient glycosylation alterations of sialylated mucin oligosaccharides during the infection of the rat intestinal parasite Nippostrongylus brasiliensis. Biochemical J., 350, 805-814.

 

126.    Thomsson, K.A., Karlsson, N.G., Hansson, G.C. (1999): Liquid chromatography- electrospray mass spectrometry as a tool for the analysis of sulfated oligosaccharides from mucin glycoproteins. J. Chromatography A 854, 131-139.

 

125.    Mu, J.Y., Johansson, M., Hansson, G.C., Lundgren, O. (1999): Lithium evokes a more  pronounced natriuresis when administered orally than when given intravenously to salt-depleted rats. Pflugers Arch. 438, 159-164.

 

124.    Sikut, R., Andersson, C. X., Sikut, A., Fernandez-Rodriguez, J., Karlsson, N. G., and Hansson G.C. (1999) Detection of CD43 (leukosialin) in colon adenoma and carcinoma cells by novel monoclonal antibodies against its intracellular domain. Int. J. Cancer, 82, 52-58.

 

123.    Paul, S., Bizouarne, N., Paul, A., Price, M.R., Hansson, G C., Kieny, M.P., Acres, R.B.(1999): Lack of evidence for an immunosuppressive role for MUC1. Cancer Immunol. Immunother. 48, 22-28.

 

122.    Asker, N., Axelsson, M.A.B., Olofsson, S.-O. and Hansson, G.C. (1998) The human MUC5AC mucin dimerizes in the rough endoplasmic reticulum, similarly to the MUC2 mucin. Biochem. J. 335, 381-387.

 

121.    Thomsson, K.A., Carlstedt, I., Karlsson, N.G., Karlsson, H., and Hansson, G.C. (1998) Different O-glycosylation of respiratory mucin glycopeptides from a patient with cystic fibrosis. Glycoconjugate J. 15, 823-883

 

120.    Axelsson, M.A.B., Hansson, E.M., Sikut, R., and Hansson G.C. (1998) Deglycosylation by gaseous hydrogen fluoride of mucus glycoproteins immobilized on nylon membranes and in microtiter wells. Glycoconjugate J., 15, 749-755.

 

119.    Axelsson, M.A.B., Asker, N., and Hansson, G.C. (1998) O-glycosylated MUC2 monomer and dimer from LS 174T cells are water soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular bonds. J. Biol. Chem. 273, 18864-18870.

 

118.    Asker, N., Axelsson, M.A.B., Olofsson, S.-O. and Hansson, G.C. (1998) Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation dependent transfer of the mono- and dimers to the Golgi apparatus. J. Biol. Chem. 273, 18857-18863

 

117.    Prokobhol, A., Thomsson, K.A., Singer, M., Hansson. G.C., Rosen, S., Leffler, H., and Fisher, S. (1998) Human low-molecular-weight salivary mucin expresses the sialyl Lewis x determinant and has L-selectin ligand activity. Biochemistry 37, 4916-4927.

 

116.    Sikut, R., Sikut, A., Zhang, K., Baeckström, D., and Hansson, G. C. (1998) Reactivity of antibodies with highly glycosylated MUC1 mucins from colon carcinoma cells and bile. Tumor Biology 19, 122-126.

 

115.    Price, M. R., Rye, P. D., Petrakou, E., Murray, A., Brady, K., Imai, S., Haga, S., Kiyozuka, Y., Schol, D., Meulenbroek, M. F. A., Snijdewint, F G. M., von Mensdorff-Pouilly, S., Verstraeten, R. A., Kenemans, P., Blockzjil, A., Nilsson, K., Nilsson, O., Reddish, M., Suresh, M. R., Koganty, R. R., Fortier, S., Baronic, L., Berg, A., Longenecker, M. B., Hilkens, J., Boer, M., Karanikas, V., McKenzie, I. F. C., Galanina, O. E., Simeoni, L. A., Ter-Grigoryan, A. G., Belyanchikov, I. M., Bovin, N. V., Cao, Y., Karsten, U., Dai, J., Allard, W. J., Davis, G., Yeung, K. K., Hanisch, F.-G., Lloyd, K. O., Kudryashov, V., Sikut, R., Sikut, A., Zhang, K., Baeckström, D., Hansson, G. C., Reis, C. A., Hassan, H., Bennett, E. P., Claussen, H., Norum, L., Varaas, T., Kierulf, B., Nustad, K., Ciborowski, P., Konitzki, W. M., Magarian-Blander, J., Finn O. J., and Hilgers, J. (1998) Summary report on the ISOBM TD-4 workshop: Analysis of 56 monoclonal antibodies against the MUVC1 mucin. Tumor Biology 19, 1-20.

 

114.    Sikut, R., Nilsson, O., Baeckström, D., and Hansson, G.C. (1997) Colon adenoma and cancer cells aberrantly express the leukocyte-associated sialoglycoprotein CD43. Biochem. Biophys. Biophys. Res. Commun. 238, 612-616.

 

113.    Karlsson, N.G., Herrmann, A., Karlsson, H., Johansson, M.E.V., Carlstedt, I., and Hansson, G.C. (1997) The glycosylation of the rat intestinal Muc2 mucin varies between rat strains and the small and large intestine. A study of O-linked oligosaccharides by a mass spectrometric approach. J. Biol. Chem. 272, 43 27025-27034.

 

112.    Helander, A., Hansson, G.C., and Svennerholm, A.-M. (1997) Binding of enterotoxogenic Eschierichia Coli to isolated enterocytes and intestinal mucus. Microbial Pathogenesis, 23, 335-346

 

111.    Karlsson, N.G., Nordman, H., Karlsson, H., Carlstedt, I., and Hansson, G.C. (1997) Glycosylation differences between pig gastric mucin populations: A comparative study of the neutral oligosaccharides using mass spectrometry. Biochem. J. 326, 911-917.

 

110.    Nordman, H., Davies, J.R., Herrmann, A., Karlsson, N.G., Hansson, G.C., and Carlstedt, I. (1997) Mucus glycoproteins from pig gastric mucosa: Identification of different mucin populations from the surface epithelium. Biochem. J. 326, 903-910.

 

109. REV: Hansson, G.C. (1997) Sialyl-Lewis a carrying MUC1 and CD43 mucin-type glycoproteins expressed and secreted from colon carcinoma cells - A role in tumor progression ? Trends Glycosci. Glycotechnology. 9, 211-222.

 

108.    Zhang, K., Sikut, R., and Hansson G.C. (1997) A MUC1 mucin secreted from a colon carcinoma cell line inhibits target cell lysis by natural killer cells. Cellular Immunol. 176, 158-165

 

107.    REV. Thomsson, K.A., Karlsson, N.G., Karlsson, H., and Hansson, G.C. (1997) Analysis of permethylated glycoprotein oligosaccharides fractions by gas chromatography-mass spectrometry. Techniques in Glycobiology. (Townsend, R.R., ed.) pp. 335-347 Marcel Dekker, New York, NY

 

106.    Zhang, K., Baeckström, D., Brevinge, H., and Hansson, G.C. (1997) Comparison of sialyl-Lewis a carrying CD43 and MUC1 mucins secreted from colon carcinoma cell line for E-selectin binding and inhibition of leukocyte adhesion. Tumour Biology, 18, 175-187.

 

105.    Sikut, R., Zhang, K., Baeckström, D., and Hansson, G.C. (1996) Distinct sub-populations of carcinoma-associated MUC1 mucins as detected by the monoclonal antibody 9H8 and antibodies against the sialyl-Lewis a and sialyl-Lewis x epitopes in the circulation of  breast-cancer patients. Int. J. Cancer 66, 617-623.

 

104.    Baeckström, D., and Hansson, G.C. (1996) The transcripts of the apomucin genes MUC2, MUC4, and MUC5AC are large and appear as distinct bands. Glycoconj. J. 13, 833-837.

 

103.    Karlsson, N.G., Karlsson, H., and Hansson, G.C. (1996) Sulphated mucin oligosaccharides from porcine small intestine analysed by four-sector tandem mass spectrometry. J. Mass. Spectrometry 31, 560-572.

 

102.    Karlsson, N.G., Johansson, M., Asker, N., Karlsson, H., Gendler, S.J., Carlstedt, I., and Hansson, G.C. (1996) Molecular characterization of the large heavily glycosylated domain glycopeptide from the rat small intestinal Muc2 mucin. Glycoconj. J. 13, 823-831.

 

101.    Klinga-Levan, K., Gum, J., Gendler, S., Kim, Y., and Hansson, G.C. (1996) Chromosomal mapping of  three mucin genes in the rat. Mammalian Genome 7, 248-250.

 

100.    Zhang, K., Baeckström, D., Brevinge, H., and Hansson, G.C. (1996) Secreted MUC1 mucins lacking their cyoplasmic part and carrying sialyl-Lewis a and x epitopes from a tumor cell line and sera of colon cancer patients can inhibit HL-60 leukocyte adhesion to E-selectin expressing endothelial cells. J. Cellular Biochemistry, 60, 538-549.

 

99. Mu, J., Hansson, G.C., and Lundgren, O. (1995) The intestinal tract and the pathophysiology of arterial hypertension: an experimental study on Dahl rats. Acta Physiol. Scand. 155, 137-146.

 

98. Mu,J.Y., Hansson,G.C., Bergström, G., and Lundgren,O., (1994) Renal sodium excretion after oral or intravenous sodium loading in sodium-deprived normotensive and spontaneously hypertensive rats. Acta Physiol. Scand. 153, 169-177

 

97. Baeckström, D., Zhang, K, Asker, N., Ruetschi, U., Ek, M., and Hansson, G.C. (1995) Expression of the leukocyte associated sialoglycoprotein CD43 by a colon carcinoma cell line. J. Biol. Chem.,270, 13688-13692.

 

96. Shimizu, T., Hansson, GC., and Strandvik, B., (1994) Defective inhibition by dexamethasone of leukotriene B4 and C4 production by leukocytes in patients with cystic fibrosis. Prostagland. Leukotrienes Essent. Fatty Acids. 51, 407-410

 

95. REV: Mu, JY., Hansson,G.C., and Lundgren, O.,(1995) The small intestine, salt intake and arterial hypertension. Blood Press. 4, 77-79.

 

94. Hansson, G.C., Mu, J.Y., and Lundgren,O., (1995) Partial purification of a factor from the feline small intestine causing natriuresis in vivo and inhibiting rubidium uptake into renal cells in vitro. Blood Press. 4, 117-125.

 

93. Asker, N., Baeckström, D., Axelsson, M., Carlstedt, I. and Hansson, G.C. (1995) The human MUC2 mucin apoprotein forms a putative dimer before O-glycosylation and shares epitopes with the 'insoluble' mucin of rat small intestine. Biochem. J., 308, 873-880.

 

92. Bouhours, D., Hansson, G.C., and Bouhours, J.-F., (1995) Structure and genetic polymorphism of blood group A-active glycosphingolipids of the rat large intestine. Biochim. Biophys. Acta. 1255, 131-140.

 

91. Karlsson, N.G., Karlsson, H., and Hansson, G.C., (1995) Strategy for the investigation of O-linked oligosaccharides from the mucins based on the separation into neutral, sialic acid- and sulfate-containing species. Glycoconjugate J., 12, 69-76.

 

90. Shimizu, T., Kristjánsson, S., Wennergrern, G., Hansson, G.C., and Strandvik, B. (1994) Inhibitory effects of theophylline, terbutaline, and hydrocortisone on leukotriene B4, and C4 generation by human leukocytes in vitro. Pediatr. Pulmonology. 18, 129-134.

 

89. Karlsson, N.G., and Hansson, G.C., (1995) Analysis of monosaccharide composition of mucin oligosaccharide alditols by high-performance anion-exchange chromatography. Anal. Biochem. 224, 538-541.

 

88. Zhang, K., Baeckström, D., and Hansson, G.C., (1994) A secreted mucin carrying sialyl-Lewis a from colon carcinoma cells binds to E-selectin and inhibits HL-60 cell adhesion. Int. J. Cancer. 59, 823-829.

 

87. Baeckström, D., Karlsson, N., and Hansson. G.C., (1994) Purification and characterization of sialyl-Lea-carrying mucins of human bile; evidence for the presence of MUC1 and MUC3 apoproteins. J. Biol. Chem. 269, 14430-14437.

 

86. Hansson, G.C., Baeckström, D., Carlstedt, I., and Klinga-Levan, K., (1994) Molecular cloning of a cDNA coding for a region of an apoprotein from the 'insoluble' mucin complex of rat small intestine. Biochem. Biophys. Res. Commun. 198, 181-190.

 

85. Karlsson, H., Karlsson, N., and Hansson, G.C., (1994) High-temperature gas chromatography and gas chromatography-mass spectrometry of glycoprotein and glycosphingolipid oligosaccharides. Mol. Biotechnology 1, 165-180

 

84. REV: Hansson, G.C., Mu, J.Y., and Lundgren, O., (1993) An intestinal natriuretric factor. J. Cardiovascular Pharm. 22, (Suppl. 2) S60-S62.

.

83. Shimizu,T., Hansson,G.C., and Strandvik, B., (1994) Effects of pancreatic and snake venom phospholipase A2 on the generation of leukotriene B4 and C4 by human lekocytes in vitro. Pancreas 9, 37-41.

 

82. Carlstedt, I., Herrmann, A., Karlsson, H., Sheehan, J., Fransson, L.-Å., and Hansson G.C., (1993) Characterization of two different glycosylated domains from the insoluble mucin complex of rat small intestine. J. Biol. Chem. 268, 18771-18781.

 

81. Baeckström, D.,Nilsson, O., Price, MR., Lindholm, L., and Hansson. G.C. (1993) Discrimination of MUC1 mucins from other sialyl-Lea carrying glycoproteins produced by colon carcinoma cells using a novel monoclonal antibody. Cancer Res. 53, 755-761.

 

80. Bouhours, D., Hansson, G.C., Ångström, J., Jovall, P.-Å., and Bouhours, J.-F., (1992) Two novel decaglycosylcermides with a blood group A-active tetrasaccharide repeat in the epithelial cells of the small intestine of inbred rats. J. Biol. Chem. 267 18533-18540.

 

79. REV: Bouhours, J.-F., Bouhours, D., and Hansson. G.C., (1993) Developmental changes of glycosphingolipid composition of epithelia of rat digestive tract. Adv. in Lipid Res. 26, 353-372.

 

78. Baeckström, D., Hansson, G.C., Nilsson, O., Johansson, C., Gendler, S.J., and Lindholm. L., (1991) Purification and characterization of a membrane-bound and a secreted mucin-type glycoproteins carrying the carcinoma-associated sialyl-Lea epitope on distinct core proteins. J. Biol. Chem. 266, 21537-21547.

 

77. Norrsell, H.,. Bengtsson, J., Jovall, P.-Å., and Hansson. G.C., (1992) N-linked glycopeptides with blood group determinants lacking neuraminic acid from the epithelial cells of rat small and large intestine. Eur. J. Biochem. 203, 285-293.

 

76. Bouhours, D., Ångström, J.,Jovall, P.-Å., Hansson, G.C., and Bouhours. J.-F., (1991) Characterization of a novel A-active octaglycosylceramide with type 1 chain repeat inherited as a recessive trait in the epithelial cells of the small intestine of inbred rats. J. Biol. Chem. 266, 18613-18619.

 

75. Hansson, G.C., Bouhours J.-F., Karlsson, H., and Carlstedt, I., (1991) Analysis of sialic acid-containing mucin oligosaccharides from porcine small intestine by high-temperature gas chromatography-mass spectrometry as their dimethylamides. Carbohydr. Res. 221, 179-189.

 

74. Hansson, G.C., and Karlsson. H., (1993) Gas chromatography and gas chromatography-mass spectrometry of glycoprotein oligosaccharides. Methods in Mol. Biol,; 14, 47-54.

 

73. Li, Y.-T., Nakagawa, H., Ross, S.C., Hansson, G.C., and Li. S.-C., (1990) A novel sialidase which releases 2,7-anhydro-N-acetylneuraminic acid from sialoglycoconjugates. J. Biol. Chem. 265, 21629-21633.

 

72. Carlstedt, I., Elmquist, S., Ljusegren, I., and Hansson, G.C., (1991) Structure and properties of rat gastrointestinal mucins. Molecular Pathogenensis of Gastrointestinal Infections (Wadstöm, T., ed.) pp. 23-28, Plenum Press, New York.

 

71. Lundgren, O., and Hansson. G.C., (1991) Is there an intestinal natriuretric factor? Acta Physiol. Scand. 141, 19-25.

 

70. Baker, N., Hansson,G.C., Leffler, H Riise, G.and Svanborg-Edén, C., (1990) Glycosphingolipid receptors for Pseudomonas aerugenosa. Infect. Immun. 58, 2361-2366.

 

69. Bouhours, D., Bouhours, J-F., Larson, G., and Hansson. G.C., (1990) Regional differences in the qappearance of adult-type glycolipids in the small intestine of inbred rats at weaning time. Arch. Biochem. Biophys. 282, 147-151.

 

68. Bouhours, D., Bouhours, J.-F., Larson, G., Karlsson, H., Pimlott, W., and Hansson. G.C., (1990) Transient expression of type 2 chain in A-active hexaglycosylceramide of rat small intestine at weaning time. Demonstration by affinity chromatography and ceramide glycanase hydrolysis of A-active glycolipids followed by gas chromatography and mass spectrometry of permethylated hexasaccharides. Arch. Biochem. Biophys. 282, 141-146.

 

67. Hansson, G.C., and Karlsson. H., (1990) High-mass gas chromatography of permethylated oligosaccharides. Methods Enzymology 193, 733-738.

 

66. Karlsson, H., Carlstedt, I., and Hansson. G.C., (1989) The use of gas chromatography and gas chromatography-mass spectrometry for the characterization of permethylated oligosaccharides with molecular mass up to 2300. Anal. Biochem. 182, 438-446.

 

65. Hansson, G.C., Li, Y.-T. and Karlsson, H., (1989) Characterization of glycosphingolipid mixtures with up to ten sugars by gas chromatography and gas chromatography mass spectrometry as permethylated oligosaccharides and ceramides released by ceramide-glycanase. Biochemistry 28, 6672-6678.

 

64. Finne, J.,Breimer, M.E., Hansson, G.C., Karlsson, K.-A., Leffler, H., Vliegenthart, J.F.G., and van Halbeek, H., (1989) Novel polyfucosylated N-linked glycopeptides with blood group A, H, X, and Y determinants from human small intestinal epithelial cells. J. Biol. Chem. 264, 5720-5735.

 

63. Karlsson, H., and Hansson, G.C., (1988) Gas chromatography and Gas chromatography /mass spectrometry for the characterization of complex mixtures of large oligosaccharides. J. High Resolution Chromatography & Chromatography Communications 11, 820-824.

 

62. Tuomanen, E., Towbin, H., Rosenfelder, G., Braun, D., Larson, G., Hansson, G.C., and Hill. R.,(1988) Receptor analogs and monoclonal antibodies that inhibit adherence of Bordetella Pertussis to human ciliated respiratory epithelial cells. J. Exp. Med. 168, 267-277.

 

61. Brändli, A.W., Hansson, G.C., Roudriguez-Boulan, E., and Simons, K., (1988) A polarized epithelial cell mutant deficient in translocation of UDP-galactose into the golgi complex. J. Biol. Chem. 263, 16283-16290.

 

60. Hansson, G.C., (1988) A blood group B-like pentaglycosylceramide is the major complex glycosphingolipid of the Madin-Darby canine kidney epithelial cell line I (MDCK I). Biochim. Biophys. Acta 967, 87-91.

 

59. Hansson, G.C., Sheehan, J.K., and Carlstedt, I. (1988) Only trace amounts of fatty acids are found in pure mucus glycoproteins. Arch. Biochem. Biophys. 266, 197-200.

 

58. PERSP. Hansson.G.C. (1988) Cystic fibrosis and chloride-secreting diarrhoea. Nature 333, 711.

 

57. Mårtensson, S., Lundblad, A., Hansson, G.C., and Carlstedt, I. (1988) Mucins obtained from patients with enterocutaneous urinary diversions. Scand. J. Clinical Invest. 48, 633-640.

 

56. Mårtensson, S., Hansson, G.C., and Lundblad.A. (1988) Intestinal-type glycosphingolipids in urine from patients with enterocutaneous urinary diversions. Arch. Biochem. Biophys. 263, 394-400.55.         Karlsson, H., Carlstedt, I., and Hansson, G.C. (1987) Rapid characterization of mucin oligosaccharides from rat small intestine with gas chromatography-mass spectrometry. FEBS Lett. 226, 23-27.

 

55. Karlsson, H., Carlstedt, I., and Hansson, G.C. (1987) Rapid characterization of mucin oligosaccharides from rat small intestine with gas chromatography-mass spectrometry. FEBS Lett. 226, 23-27.

 

54. Ångström, J., Falk, P., Hansson, G.C., Holgersson, J., Karlsson, H., Karlsson, K-A., Strömberg, N., and Thurin, J. (1987) The mono-and difucosyl blood group B glycosphingolipids of rat large intestine differ in type of core saccharide. Biochim. Biophys. Acta 926, 79-86.

 

53. Hansson, G.C., Wazniowska, K., Rock, J.A., Ness, P.M., Kickler, T.S., Shirey, R.S., Niebyl, J.R., and Zopf, D. (1988) The glycosphingolipid composition of the placenta of a blood group P fetus delivered by a blood group P1k-woman and analysis of the anti-globoside antibodies found in maternal serum. Arch. Biochem. Biophys. 260, 168-176.

 

52. Bouhours, J.-F., Bouhours, D., and Hansson, G.C. (1987) Developmental changes of gangliosides in rat stomach. Appearance of a blood group B-active ganglioside. J. Biol. Chem. 262, 16370-16375.

 

51. Hansson, G.C., Bouhours, J.-F., and Ångström, J., (1987) Characterization of neutral blood group B-active glycosphingolipids of rat gastric mucosa. A novel type of blood group active glycosphingolipid based on isogloboside. J. Biol. Chem. 262, 13135-13141.

 

50. Bouhours, D., Larson, G., Bouhours,  J.-F., Lundblad, A., and Hansson.G.C. (1987) Developmental changes of blood group A-active glycosphingolipids with type 1 and type 2 chains in rat small intestine. Glycoconjugate J. 4, 59-71.

 

49. Larson, G., Karlsson, H., Hansson, G.C., and Pimlott.W. (1987) Application of a simple methylation procedure for the analyses of glycosphingolipids. Carb. Res. 161, 281-290.

 

48. Björk, S., Breimer, M.E., Hansson, G.C., Karlsson, K.-A., and Leffler, H. (1987) Structures of blood group glycosphingolipids of human small intestine. A relation between the expression of fucolipids of epithelial cells and the ABO, Le and Se phenotype of the donor. J. Biol. Chem. 262, 6758-6765.

 

47. Dakour, J., Hansson, G.C.,Lundblad, A., and Zopf, D. (1986) Separation and partial sequence analysis of blood group A-active oligosaccharides by affinity chromatography using monoclonal antibodies. Arch. Biochem. Biophys. 248, 677-683.

 

46. REV: Zopf, D., and Hansson. G.C., (1988) The chemical basis for expressionof the sialyl-Lea antigen. In: Molecular Immunology of Complex Carbohydrates (A. Wu, ed.) Plenum Press, 657-676.

 

45. Hansson, G.C., Simons, K., and van Meer, G., (1986) Two strains of the Madin-Darby canine kidney (MDCK) cell line have distinct glycosphingolipid compositions. EMBO J., 5, 483-489.

 

44. REV: Hansson, G.C. (1988) Structural aspects of blood group glycosphingolipids in the gastrointestinal tract. In: Molecular Immunology of Complex Carbohydrates (A. Wu, ed.) Plenum Press. 465-494.

 

43. Zopf, D., Schroer, K., Hansson, G.C., Dakour, J., and Lundblad, A.(1987) Affinity purification of oligosaccharides using monoclonal antibodies. Methods Enzymology 138, 307-313.

 

42. Hansson, G.C., Karlsson, K.-A.,. Larson,G., Samuelsson, B.E., Thurin, J., and Bjursten. L.M. (1985),Detection of blood group type glycosphingolipid antigens on thin-layer plates using polyclonal antisera. J. Immunol. Methods 83, 37-42.

 

41. Breimer, M.E., Hansson, G.C., and Leffler. H., (1985) The specific glycosphingolipid composition of human ureteral epithelial cells. J. Biochem. 98U,U 1169-1180.

 

40. Leffler, H., Hansson, G.C., and Strömberg. N., (1986) A novel sulfoglycosphingolipid of mouse small intestine, IV3-sulfogangliotetraosylceramide, demonstrated by negative ion fas atom bombardment mass spectrometry. J. Biol. Chem. 261, 1440-1444.

 

39. Hansson, G.C., and Zopf. D. (1985) Biosynthesis of the cancer-associated Sialyl-Lea antigen. J. Biol. Chem. 260, 9388-9392.

 

38. Bock, K., Breimer, M.E., Brignole, A., Hansson, G.C., Karlsson, K.-A., Larson, G. Leffler, H. Samuelsson, B.E., Strömberg, N., Svanborg-Edén, C., and Thurin. J. (1985) Specificity of binding of a strain of uropathogenic UEscherichia coliU to Galax1-4Gal-containing Glycosphingolipids. J. Biol. Chem. 260, 8545-8551.

 

37. Hansson, G.C., Karlsson, K.-A., Larson, G., Strömberg, N., and Thurin. J. (1985) Carbohydrate-specific adhesion of bacteria to thin-layer chromatograms. A rationalized approach to the study of host cell glycolipid receptors. Anal. Biochem. 146U,U 158-163.

 

36. Blaszczyk, M., Hansson, G.C., Karlsson, K.-A., Larson, G., Strömberg, N., Thurin, J., Herlyn, M., Z. Steplewski., and Koprowski. H. (1984) Lewis blood group antigens defined by monoclonal anti-colon carcinoma antibodies. Arch. Biochem. Biophys. 233, 161- 168.

 

35. Hansson, G.C., Karlsson, K.-A., Larson, G., Strömberg, N., Thurin, J., Örvell, C., and Norrby. E. (1984) A novel approach to the study of glycolipid receptors for viruses. Binding of sendai virus to thin-layer chromatograms. FEBS Lett. 170, 15-18.

 

34. Hansson. G.C. (1983) The structure of two blood group A-active glycosphingolipids with 12 sugars and a branched chain present in the epithelial cells of rat small intestine. J. Biol. Chem. 258, 9612-9615.

 

33. Söderström, T., Hansson, G.C., and Larson. G. (1984) The UEscherichia ColiU Kl Capsule shares antigenic determinants with the human gangliosides GM3 and GD3. The New Engl. J. Med. 310, 726-727.

 

32. Hansson, G.C., Karlsson, K.-A., and Thurin. J. (1984) Glycosphingolipid patterns of the epithelial and non-epithelial compartments of rat large intestine. Biochim. Biophys. Acta. U792,U 281-292.

 

31. REV: Björk, S., Breimer, M.E., Hansson, G.C., Karlsson, K.-A., Larson, G., and Leffler. H. (1983) Blood group glycosphingolipids of human gastrointestinal tissues. Red cell membrane glycoconjugates and related genetic markers ( Cartron, J.-P., Rouger, P., Salmon, C., eds.) Libraire Arne, Paris, pp. 125-137.

 

30. Hansson, G.C. (1983) The subcellular localization of the glycosphingolipids in the epithelial cells of rat small intestine. Biochim. Biophys. Acta. 733, 295-299.

 

29. Hansson, G.C., Karlsson, K.-A., Larson, G., McKibbin, J.M., Blaszczyk, M., Herlyn, M., Steplewski, Z., and Koprowski. H. (1983) Mouse monoclonal antibodies against human cancer cell lines with specificities for blood group and related antigens. Characterization by antibody binding to glycosphingolipids in a chromatogram binding assay. J. Biol. Chem. 258, 4091-4097.

 

28. Breimer, M.E., Hansson, G.C., Karlsson, K.-A., and Leffler. H. (1983) The preparative separation of sialic acid-containing lipids from sulphate group-containing glycolipids from small intestine of different animals. Analysis by thin-layer chromatography and detection of novel species. J. Biochem. 93, 1473-1485.

 

27. Hansson, G.C., Karlsson, K.-A., Larson, G., McKibbin, J.M., Strömberg, N., and Thurin. J. (1983) Isoglobotriaosylceramide and the Forssman glycolipid of dog small intestine occupy separate tissue compartments and differ in ceramide composition Biochim. Biophys. Acta. 750, 214-216.

 

26. Breimer, M.E., Hansson, G.C., Karlsson, K.-A., Larson, G., Leffler, H., Pimlott, W., Samuelsson, B.E., Strömberg, N., Teneberg, S., and Thurin. J. (1983) Sequencing of large oligosaccharides by direct inlet mass spectrometry. Application to cell surface glycolipids. Int. J. Mass Spectrom. Ion Phys. 48, 113-116.

 

25. Hansson, G.C., Karlsson, K.-A., Leffler, H., and Strömberg. N. (1982) Gangliotetraosylceramide is a major glycolipid of epithelial cells of mouse small intestine. FEBS Lett.139, 291-294.

 

24. Hansson. G.C. (1981) The structure and localization of glycosphingolipid antigens in the small intestine and alteration at epithelial cell differentiation. Dissertation

 

23. Ångström, J., Breimer, M.E., Falk, K.-E., Hansson, G.C., Karlsson, K.-A., Leffler, H., and Pascher.I. (1982) Structural characterization of glycolipids of rat small intestine having one to eight hexoses in a linear sequence. Arch. Biochem. Biophys. 213, 708-725.

 

22. Breimer, M.E., Hansson, G.C., Karlsson, K-A., and Leffler. H. (1982) Studies on differentiating epithelial cells of rat small intestine. Alterations in the lipophilic part of glycosphingolipids during cell migration from crypt to villus tip. Biochem. Biophys. Acta. 710, 415-427.

 

21. Breimer, M.E., Hansson, G.C., Karlsson, K.-A., and Leffler. H. (1982) Glycosphingolipids of rat tissues. Different composition of epithelial and nonepithelial cells of small intestine. J. Biol. Chem. 257, 557-568.

 

20. Breimer, M.E., Hansson, G.C., Karlsson, K.-A., and Leffler. H. (1982) Isolation and partial characterization of blood group A and H active glycosphingolipids of rat small intestine. J. Biol. Chem. 257, 906-912.

 

19. Ångström, J., Breimer, M.E., Falk, K.-E., Hansson, G.C., Karlsson., K.-A., and Leffler, H. (1982) Chemical characterization of penta-, hexa-, hepta-, octa-, and nonaglycosylceramides of rat small intestine having a globoside-like terminus. J. Biol. Chem. 257, 682-688.

 

18. Breimer, M.E., Falk, K.-E., Hansson, G.C., and Karlsson, K.-A., (1982) Structural identification of two ten-sugar branched chain glycosphingolipids of blood group H type present in epithelial cells of rat small intestine. J. Biol. Chem. 257, 50-59.

 

17. Ångström. J., Breimer, M.E., Falk, K.-E., Griph, I., Hansson, G.C., Karlsson, K.-A., and Leffler, H. (1981) Separation and characterization of hematosides with different sialic acids and ceramides from rat small intestine. Different composition of epithelial cells UversusU non-epithelial tissue and of duodenum UversusU jejunum-ileum. J. Biochem. 90, 909-921.

 

16. Breimer, M.E., Hansson, G.C., Karlsson, K.-A., and Leffler.H. (1981) Blood group type glycosphingolipids from the small intestine of different animals analysed by mass spectrometry and thin-layer chromatography. A note on species diversity. J. Biochem. 90, 589-609.

 

15. Breimer, M.E., Hansson, G.C., Karlsson, K.-A., and Leffler. H. (1981) Glycosphingolipids and the differentiation of intestinal epithelium. Exp.Cell Res. 135, 1-13.

 

14. Dahlgren, K.-E., Emilsson, P.M., Hansson, G.C., and Samuelsson. B.E. (1981) Preparation and characteristics of liposomes containing glycosphingolipids with blood group activity. Adaptation for an improved immunologic micromethod based on inhibition of haemagglutination. J. Immunol. Methods. 44, 223-234.

 

13. Breimer, M.E., Hansson, G.C., Karlsson, K.-A., Leffler, H., Pimlott, W., and Samuelsson. B.E. (1981) Sequencing of oligosaccharides by mass spectrometry applied on a 12-sugar glycolipid. FEBS Letters. 124, 299-303.

 

12. Esmann, M., Christiansen, C., Karlsson, K-A., Hansson, G.C., and Skou. J.C. (1980) Hydrodynamic properties of solubilized (Na+ + K+)-ATPase from rectal glands of USqualus acanthiasU. Biochim. Biophys. Acta. 603, 1-12.

 

11. Hansson, G.C., Karlsson, K.-A., and Thurin, J. (1980) Glycolipids of rat large intestine. Characterization of a novel blood group B-active tetraglycosylceramide absent from small intestine. Biochim. Biophys. Acta .620, 270-280.

 

10. REV: Breimer, M.E., Hansson, G.C., Karlsson, K-A., and Leffler, H. (1980) Glycolipids of rat small intestine with special reference to epithelial cells in relation to differentiation. Cell Surface Glycolipids (C.C.Sweeley, ed.) ACS Symposium Series, 128, 79-104. The American Chemical Society, Washington DC.

 

9.   Breimer, M.E., Hansson, G.C., Karlsson, K-A., and Leffler, H. (1980) Demonstration of complexity of the glycosphingolipid fraction of rat small intestine. Biochem. Biophys. Res.Commun. 95, 416-422.

 

8.   Breimer, M.E., Hansson, G.C., Karlsson, K-A., and Leffler. H. (1980) Human blood group A-positive and -negative strains of rat. Chemical basis as shown by fucolipids of small intestine. FEBS Letters 114, 51-56.

 

7.   Breimer, M.E., Hansson, G.C., Karlsson, K-A., and Leffler. H. (1980) Glycolipids of rat small intestine. Characterization of a novel blood group H-active triglycosylceramide. Biochim. Biophys. Acta 617, 85-96.

 

6.   REV: Breimer, M., Hansson, G., Karlsson, K-A., Larson, G., Leffler, H., Pascher,I., Pimlott, W., and Samuelsson, B. (1980) Fingerprinting of lipid-linked oligosaccharides by mass spectrometry. Advances in Mass Spectrometry 8, 1097-1108, (Quayle, A., ed.) Heyden and Son, London,

 

5.   REV: Breimer, M.E., Hansson, G.C., Karlsson, K-A., Larson, G., Leffler, H.,.Pascher, I.,Pimlott, W., and Samuelsson. B.E. (1979) Mass Spectrometry of Glycolipids.  Advances in the Biochemistry and Physiology of Plant Lipids 281-286, (Appelqvist L-Å., and Liljenberg, C., eds.) Elsevier/North Holland Biomedical Press

 

4.   Breimer, M.E., Hansson, G.C., Karlsson, K-A., Leffler, H., Pimlott, W., and Samuelsson. B.E. (1979) Selected ion monitoring of glycosphingolipid mixtures. Identification of several blood group type glycolipids in the small intestine of an individual rabbit. Biomed. Mass Spectrometry. 6, 231-241.

 

3.   Hansson, G.C., Heilbronn, E., Karlsson, K-A., and Samuelsson,B.E. (1979) The lipid composition of the electric organ of the ray, UTorpedo marmorataU, with specific reference to sulfatides and Na+-K+-ATPase. J. Lipid Res. 20, 509-518.

 

2.   Breimer, M.E., Hansson, G.C., Karlsson, K-A., Leffler, H., Pimlott, W., and Samuelsson. B.E. (1978) Structure determination of blood group type glycolipids of cat small intestine by mass fragmentography. FEBS Letters 89, 42-46.

 

1.   Hansson, C.G., Karlsson, K-A., and Samuelsson, B.E. (1978) The identification of sulphatides in human erythrocyte membrane and their relation to sodium-potassium dependent adenosine triphosphatase. J. Biochem. 83, 813-819.

 

Authors appear in alphabetic order on papers published together with K.-A. Karlsson.


DISSERTATIONS

 

1      Dan Baeckström (1995) Studies on the structure and expression of sialyl-Lewis a-carrying mucins in colon carcinoma and bile.

 

2      Jianying Mu (1996) The intestine, salt intake and arterial hypertension (together with Ove Lundgren, Dept. Physiology).

 

3      Ke Zhang (1997) Sialyl-Lewis a-carrying mucins secreted from colon carcinoma bind to E-selectin and inhibits leukocyte adhesion to E-selectin expressing cells and natural killer cytotoxic lysis.

 

4      Niclas Karlsson (1997) Glycosylation of intestinal mucins in health and disease.

 

5.   Rein Sikut (1998) Studies on the carcinoma-associated mucin type molecules MUC1 and CD43.

 

6.   Noomi Asker (1998) Assembly of the large glycoprotein MUC2, an intestinal gel-forming mucin.

 

7.   Magnus Axelsson (1999) On the assembly and O-glycosylation of the MUC2 mucin. Crucial steps in the formation of the intestinal mucus barrier.

 

8.   Kristina Thomsson (2000) Analytical approaches to the study of mucin glycosylation.

 

9.   Fredrik Olson (2002) Alteration in mucin O-glycosylation in response to intestinal infection.

 

10. Christian Andersson (2003) Expression and novel functions of CD43 in colon cancer cells

 

11. Sirle Laos (2005) Tumor biological aspects of the mucin-like glycoprotein CD43

 

12. Martin Lidell (2006) Assembly and proteolytic cleavages of gel-forming mucins

 

13. Emily Malmberg (2006) Mucins, Cystic Fibrosis and PDZ protein interactions

 

14. Jessica Holmén Larsson (2006) O-glycosylation of intestinal and respiratory mucins in health and disease

 

15. Tiange Lang (2007) Evolution of Transmembrane and Gel-forming Mucins Studied with Bioinformatic Methods

 

16. Malin E.V. Johansson (2009) The MUC2 mucin – a network in the intestine protective mucus

 

17. Jenny Gustafsson (2012) Colonic barrier function in ulcerative colitis – interactions between ion and mucus secretion

 

18. Thaher Pelaseyed (2012) The relationship between transmembrane mucins, ion channels and PDZ adaptor proteins in the small intestine

 

19. Joakim Bergström (2014) Mucus associated proteins and their functional role in the distal intestine

 

20. Sjoerd van der Post (2014) Study of the colonic mucus layer y mass spectrometry

 

21. Karolina Sjöberg Jabbar (2018) Early stage inflammation and cancer as reflected in the gastrointestinal mucus composition